Cyclooxygenase-2 gene and lung carcinoma risk

Abstract

In this study, we aimed to investigate a possible association of the COX-2 polymorphisms with the risk of developing lung carcinoma. COX-2 (-765G→C; -1195A→G) gene polymorphisms were performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism in 118 healthy individuals and 231 patients with lung carcinoma. The present study was the first that addressed the role of the COX-2-765G→C and -1195A→G polymorphisms in lung carcinoma in Turkish population. In the present study, we found that the frequencies of GG, CC, and CG genotypes of COX-2-765G→C and AA, GG, and AG genotypes of -1195A→G in our control group were 0.22, 0.22, 0.55 and 0.59, 0.0, 0.40, respectively. These frequencies in patient group were 0.34, 0.07, 0.58 and 0.74, 0.04, 0.24, respectively. There were statistically significant differences in COX-2-765G→C (P=0.0002) and -1195A→G genotypes (P=0.007) between the controls and patients. We found that individuals carrying -765 GG genotype and -765 G allele of COX-2 or 1195 AA genotype of COX-2 and -765G: -1195A haplotype had an increased risk for the development of lung carcinoma. In contrast, individuals with -765 CC, -1195 AG genotypes and -1195 G allele of COX-2 seem to be protective from lung carcinoma. We suggest that the COX-2-765G→C and -1195A→G genotypes may be a risk factor for lung carcinoma.

Functional polymorphisms of the cyclooxygenase-2 gene and prognosis of hepatocellular carcinoma - a cohort study in Chinese people

“…The -765G>C (rs20417) and -1195G>A (rs689466) polymorphisms in the COX-2 gene are among the most extensively studied SNPs. As an inflammation-associated enzyme, COX-2 plays important roles in cell apoptosis, proliferation, differentiation, and angiogenesis, and is thus involved in the pathogenesis of solid tumors (Coskunpinar et al, 2011;Gangwar et al, 2011;Talar-Wojnarowska et al, 2011). Recently, a number of studies have focused on the influence of COX-2 SNPs on risk of various cancers including HCC, but very few have investigated their role in the progression of these diseases (Festa-Vasconcellos et al, 2012).…”

“…So far, published data regarding the clinical significance of COX-2 -765G>C and -1195G>A polymorphisms have been controversial (Talar-Wojnarowska et al, 2011) The -765C allele has been reported to be associated with either increased or decreased risk for various cancers by different studies (Zhao et al, 2009;Coskunpinar et al, 2011;Gangwar et al, 2011). The -1195G>A polymorphism was also considered to have opposite effects on tumorigenesis in different types of cancers, as reported by different research groups (Kristinsson et al, 2009;Pereira et al, 2010).…”

Cyclooxygenase-2 polymorphisms and the risk of gastric cancer in various degrees of relationship in the Chinese Han population

“…As COX-2-1195G>A and H. pylori were involved in gastric cancer, the interaction between this functional SNP and H. pylori infection status was examined (16)(17)(18), which indicated that the COX-2-1195AA genotype was associated with advanced colorectal cancer, asthma and lung carcinoma, respectively. However, Peters et al (19) reported that there was no significant difference in the genotype distribution of COX-2-1195A>G polymorphism between patients and controls in the risk of head and neck cancer in Caucasian individuals.…”

Lack of association between the cyclooxygenase 2 -765G>C polymorphism and prostate cancer risk: a meta-analysis

“…Over the last decade, numerous molecular epidemiological case-control studies have been conducted in diverse ethnic backgrounds to explore the association between the COX2 -765G>C polymorphism and risks of various cancers, including breast cancer (Piranda et al, 2010), colorectal carcinoma (Daraei et al, 2012), esophageal (Bye et al, 2011) and gastric cancers , hepatocellular carcinoma (He et al, 2012), leukemia (Zheng et al, 2011), lung cancer (Coskunpinar et al, 2011), lymphoma (Monroy et al, 2011), ovarian (Agachan Cakmakoglu et al, 2011, head and neck (Peters et al, 2009), pancreatic (Zhao et al, 2009), skin (Cocoş et al, 2012), and cervical cancers (Pandey et al, 2010), among others. However, due to the relatively small sample sizes, the results obtained from these studies have been inconclusive or even controversial.…”