Cyclopentadienyl-technetium-tri-carbonyl

Palm, Chr.; Fischer, Ernst Otto; Baumgärtner, F.

doi:10.1007/bf00622427

Cited by 26 publications

(5 citation statements)

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“…Fundamental compound (classes) and complexes reported in the 20th century: 1–4, − 5, 6, 7, 8, and 9–18. − …”

Section: Introductionmentioning

confidence: 99%

Role of Pure Technetium Chemistry: Are There Still Links to Applications in Imaging?

Alberto

2023

Inorg. Chem.

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The discovery and development of new 99m Tc-based radiopharmaceuticals or labeled drugs in general is based on innovative, pure chemistry and subsequent, application-targeted research. This was the case for all currently clinically applied imaging agents. Most of them were market-introduced some 20 years ago, and the few more recent ones are based on even older chemistry, albeit technetium chemistry has made substantial progress over the last 20 years. This progress though is not mirrored by new molecular imaging agents and is even accompanied by a steady decrease in the number of groups active in pure and applied technetium chemistry, a contrast to the trends in most other fields in which d-elements play a central role. The decrease in research with technetium has been partly counterbalanced by a strong increase of research activities with homologous, cold rhenium compounds for therapy, disclosing in the future eventually a quite unique opportunity for theranostics. This Viewpoint analyzes the pathways that led to radiopharmaceuticals in the past and their underlying fundamental contributions. It attempts to tackle the question of why new chemistry still does not lead to new imaging agents, i.e., the question of whether pure technetium chemistry is still needed at all.

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“…Fundamental compound (classes) and complexes reported in the 20th century: 1–4, − 5, 6, 7, 8, and 9–18. − …”

Section: Introductionmentioning

confidence: 99%

Role of Pure Technetium Chemistry: Are There Still Links to Applications in Imaging?

Alberto

2023

Inorg. Chem.

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“…Bei negativeren Potentialen tritt in so reduzierten Losungen einc weiterc Stromstufe auf, die zur Reaktion Tc 3+ + e" --Tc 2+ gehoren konnte.Bei der Rcdiiktion vierwertiger Tcchnctiumvcrbindungen in salzsaurer Losung mit chemischen Rcduktionsmittcin entstehen zahlreiche, nieist itnbcknnntc Produkto. Aus deni Reaktionsgemisch mit Hydroxylamin konntc cin rosa gefiirbter Komplcx der Zusammensctzung (Tc(XH 2 OH) 2 -(XH 3 ) 3 1I 2 O] 2+ isoliert werden[50]. Jlit Zink entsteht einc blaugefiirbte intermediare Vcrbindung, die als binuklearer Komplex der Zusammensetzung Tc 2 Clg + beschrieben wird (Abb.…”

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Stand Und Entwicklungstendenzen auf Dem Gebiet Der Radiochemie und Chemischen Kerntechnik Chemie Ausgewäiilter Radioaktiver Elemente

Münze

1978

Isotopenpraxis Isotopes in Environmental and Health Studies

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“…Although reports of carbonyl derivatives of Mn and Re are abundant in the literature [2a-d], only few cyclopentadienyl carbonyls of technetium have been reported so far [3][4][5]. η 5 -Cyclopentadienyl technetium tricarbonyl, C 5 H 5 Tc(CO) 3 , has been obtained by neutron bombardment of cyclopentadienyl molybdenum tricarbonyl dimer followed by radioactive decay [3] and by reaction of TcCl 4 with sodium cyclopentadienide in ethyleneglycol dimethylether under 325 atm of carbon monoxide [4].…”

Section: Introductionmentioning

confidence: 99%

“…η 5 -Cyclopentadienyl technetium tricarbonyl, C 5 H 5 Tc(CO) 3 , has been obtained by neutron bombardment of cyclopentadienyl molybdenum tricarbonyl dimer followed by radioactive decay [3] and by reaction of TcCl 4 with sodium cyclopentadienide in ethyleneglycol dimethylether under 325 atm of carbon monoxide [4]. On a small scale, acylation of the ring ligand with benzoyl chloride to Synthesis, reactions and structure of Cp´Tc(CO) 3 3 ] has also been achieved [5].…”

Section: Introductionmentioning

confidence: 99%

“…As part of a project aimed at the development of new radiopharmaceuticals we decided to explore a new area of organotechnetium chemistry based on Tc 2 (CO) 10 as starting material and to focus on the preparation of low-valent pentamethylcyclopentadienyl carbonyl complexes. With 99 Tc readily available in the form of ammonium pertechnetate, NH 4 99 TcO 4 , and with the explosive development of cyclopentadienyl rhenium chemistry [1a-f] in mind, we have synthesized and characterized some new pentamethylcyclopentadienyl complexes of technetium. The results of this research are reported below.…”

Section: Introductionmentioning

confidence: 99%

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