Cyclopeptide alkaloids of Ziziphus oxyphylla Edgw as novel inhibitors of α-glucosidase enzyme and protein glycation

Olax subscorpioidea Oliv. Leaf Alleviates Postprandial Hyperglycaemia by Inhibition of α-amylase and α-glucosidase

“…The presence of only alkaloids, cardiac glycosides and tannins was detected in the hexane extract. Alkaloids have been shown to display wide spectrum antidiabetic potentials-by inhibiting diabetes-related enzymes like α-glucosidase and preventing protein glycation (Choudhary et al, 2011). Tannins on the other hand, are exhibits insulin-mimetic effect by improving the sensitivity of insulin receptors (Huang et al, 2005) while cardiac glycosides prevent diabetes-related complications by inhibiting Na + /K + pump, thereby improving cardiac output and preventing cardiovascular diseases (Krishnaiah et al, 2009).…”

Synthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase andα-glucosidase inhibition

“…-Glucosidase ınhibition assay a-Glucosidase inhibition assay was performed spectrophotometrically 46 . a-Glucosidase from Saccharomyces cerevisiae (SigmaAldrich, St. Louis, MO) was dissolved in phosphate buffer (pH 6.8, 50 mM).…”

“…Test compound was replaced by DMSO (7.5% final) as control. Acarbose (SigmaAldrich) was used as a standard inhibitor 46 . 1,2,4-triazole-3-thiones and 1,3,4-oxadiazole-2(3H)-thione were synthesized.…”

Isolation of a new bioactive cinnamic acid derivative from the whole plant of Viola betonicifolia

“…Test compound was replaced by DMSO (10% final) as control. Rutin was used as the standard antiglycating agent 29 . The percent inhibition of advanced glycation endproduct (AGE) formation was calculated as:…”

“…After 48 h the medium was again replaced with (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) MTT (0.5 mg/mL, prepared in PBS and DMEM), and incubated for 4 h. Then 100% DMSO was added and left for 15 min and reading was taken at 570 nm. Test compound was replaced with DMSO (final, 0.7%) as control 29 . Doxorubicin was used as the standard inhibitor.…”