Cyclophane zur Komplexierung von Neutralmolekülen

Recognition of Aromatic Compounds by π Pocket within a Cage‐Shaped Borate Catalyst

“…Enzymes utilize an affinity for chemical bonding and steric demand to distinguish an appropriate target. To overcome this problem, we focused on clathrate compounds such as molecular clips, [6] molecular tweezers, [7] and cyclophanes, [8] which are known to recognize aromatic compounds within their p-space cavity through aromatic-aromatic interactions. [2] In almost all cases, useful protocols involve metal-heteroatom binding [3, 4] and steric interactions between the ligands and the targeted molecules.…”

“…[1] In addition, metal complexes have been often applied to the selective recognition of targeted molecules. To overcome this problem, we focused on clathrate compounds such as molecular clips, [6] molecular tweezers, [7] and cyclophanes, [8] which are known to recognize aromatic compounds within their p-space cavity through aromatic-aromatic interactions. [5] Namely, the recognition has been shown in terms of electronic or steric factors.…”

Foldamer‐based Molecular Recognition

“…Supramolecular chemists have been very successful in using the principles of pre-organization and complementarity to design receptors with high affinity and selectivity [2][3][4]. The formulation of the lock and key principle to explain enzymatic action highlighted the importance of complementarity for successful molecular recognition and played a central role in the later development of the field of supramolecular chemistry.…”

New Exo-Functional Cyclophane Hosts. Synthesis and Crystal Structures of Inclusion Compounds

“…They feature a rather rigid host framework arising from the assembly of aromatic groups, which leads to well-defined cavity structures [8,9]. Angular diphenyl methane or analogously shaped building blocks have been used most frequently for this purpose [10-131. Corresponding cyclophanes are versatile host compounds represented by a great many structures in which the guest is either entrapped in the cyclophane cavity or is sandwiched between the host molecules in the crystal lattice [6,[9][10][11][12][13].…”