Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma

Cocozza, Federico; Menay, Florencia; Tsacalian, Rodrigo; Elisei, Analia; Sampedro, Pura Isabel; Soria, Ivana; Waldner, Claudia; Gravisaco, Marí­a José; Montagnoli, Claudia

doi:10.1016/j.vaccine.2019.02.004

Cited by 16 publications

(4 citation statements)

References 66 publications

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“… 164 Additionally, a method for increasing the yield of EVs by cyclophosphamide treatment has been reported, which may be used to produce antigens for future design of cancer vaccines. 161 Exosome engineering approaches, such as decorating tumor peptides on the exosome surface and microfluidic technique, have also been utilized to enhance the ability of harvested exosomes in antigen presentation and T cell activation in future vaccine design. 165 166 One attractive approach is engineering EVs to allow their specific uptake by DCs and induce antigen-specific T cell responses.…”

Section: Introductionmentioning

confidence: 99%

Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment

Vayalil

Lee

et al. 2021

J Immunother Cancer

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Immunotherapeutic drugs including immune checkpoint blockade antibodies have been approved to treat patients in many types of cancers. However, some patients have little or no reaction to the immunotherapy drugs. The mechanisms underlying resistance to tumor immunotherapy are complicated and involve multiple aspects, including tumor-intrinsic factors, formation of immunosuppressive microenvironment, and alteration of tumor and stromal cell metabolism in the tumor microenvironment. T cell is critical and participates in every aspect of antitumor response, and T cell dysfunction is a severe barrier for effective immunotherapy for cancer. Emerging evidence indicates that extracellular vesicles (EVs) secreted by tumor is one of the major factors that can induce T cell dysfunction. Tumor-derived EVs are widely distributed in serum, tissues, and the tumor microenvironment of patients with cancer, which serve as important communication vehicles for cancer cells. In addition, tumor-derived EVs can carry a variety of immune suppressive signals driving T cell dysfunction for tumor immunity. In this review, we explore the potential mechanisms employed by tumor-derived EVs to control T cell development and effector function within the tumor microenvironment. Especially, we focus on current understanding of how tumor-derived EVs molecularly and metabolically reprogram T cell fates and functions for tumor immunity. In addition, we discuss potential translations of targeting tumor-derived EVs to reconstitute suppressive tumor microenvironment or to develop antigen-based vaccines and drug delivery systems for cancer immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment

Vayalil

Lee

et al. 2021

J Immunother Cancer

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“…These results indicated that B lymphoma cell-derived exosomes might be able to induce tumor antigen-specific anti-tumor immunity. In vivo experiments in a mouse model of TCL also confirmed that TDE could induce humoral and cellular immune responses ( 83 ). Therefore, TDE may serve as a potential source of lymphoma cell-related antigen immunotherapy.…”

Section: Lbs In Treatmentmentioning

confidence: 86%

Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma

Liu

2021

Front. Oncol.

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Non-Hodgkin lymphoma (NHL) is a common type of hematological malignant tumor, composed of multiple subtypes that originate from B lymphocytes, T lymphocytes, and natural killer cells. A diagnosis of NHL depends on the results of a pathology examination, which requires an invasive tissue biopsy. However, due to their invasive nature, tissue biopsies have many limitations in clinical applications, especially in terms of evaluating the therapeutic response and monitoring tumor progression. To overcome these limitations of traditional tissue biopsies, a technique known as “liquid biopsies” (LBs) was proposed. LBs refer to noninvasive examinations that can provide biological tumor data for analysis. Many studies have shown that LBs can be broadly applied to the diagnosis, treatment, prognosis, and monitoring of NHL. This article will briefly review various LB methods that aim to improve NHL management, including the evaluation of cell-free DNA/circulating tumor DNA, microRNA, and tumor-derived exosomes extracted from peripheral blood in NHL.

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“…[ 62 ] It was also shown that cyclophosphamide can increase its yield without altering the immune properties of exosomes. [ 63 ]…”

Section: Engineering Therapies Of Exosomesmentioning

confidence: 99%

Exosomes as Potential Functional Nanomaterials for Tissue Engineering

Yao

Jiang

Song

et al. 2022

Adv Healthcare Materials

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Exosomes are cell‐derived extracellular vesicles of 40–160 nm diameter, which carry numerous biomolecules and transmit information between cells. They are used as functional nanomaterials with great potential in biomedical areas, such as active agents and delivery systems for advanced drug delivery and disease therapy. In recent years, potential applications of exosomes in tissue engineering have attracted significant attention, and some critical progress has been made. This review gives a complete picture of exosomes and their applications in the regeneration of various tissues, such as the central nervous systems, kidney, bone, cartilage, heart, and endodontium. Approaches employed for modifying exosomes to equip them with excellent targeting capacity are summarized. Furthermore, current concerns and future outlook of exosomes in tissue engineering are discussed.

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Cyclophosphamide enhances the release of tumor exosomes that elicit a specific immune response in vivo in a murine T-cell lymphoma

Cited by 16 publications

References 66 publications

Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment

Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment

Clinical Application of Liquid Biopsy in Non-Hodgkin Lymphoma

Exosomes as Potential Functional Nanomaterials for Tissue Engineering

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