Cyclophosphamide in Hodgkin's Disease and Related Disorders

Chemotherapy of Hodgkin's Disease with Cyclophosphamide, Vinblastine, and Procarbazine

“…Cyclophosphamide, like other forms of nitrogen mustard, is an accepted agent in the treatment of Hodgkin's disease, and our results are similar to those of other workers (Bethell et al, 1960;Matthias et al, 1960;Rundles et al, 1962;Fairley and Simister, 1964).…”

Cyclophosphamide in Treatment of Disseminated Malignant Disease

“…Varying degrees of success have been reported by other workers using cyclophosphamide in a wide range of malignant discase (Gross and Lambers, 1958;Snyman and Falkson, 1960 ;Korst et al, 1960;Matthias et al, 1960;Molin, 1961 ;Stoll and Matar, 1961).…”

Cancer chemotherapy--the first twenty-five years.

“…In spite of its insecure theoretical foundation, it has proved a useful drug. It is of great value in Hodgkin's disease, myelomatosis, chronic lymphatic leukaemia, and reticulosarcoma, and often of benefit in mammary and ovarian carcinoma (Coggins et al, 1959;Haar et al, 1960;Matthias et al, 1960;Fairley and Simister, 1964). It leads to alopecia more readily than other alkylating agents, and irritant metabolites excreted in the urine are apt to produce a chemical cystitis.…”