Cyclophosphamide-induced testicular injury: the role of chrysin in mitigating iron overload and ferroptosis
Dalia O. Saleh,
Nesma M. E. Abo El Nasr,
Yosra A. Hussien
et al.
Abstract:This study evaluated the beneficial effects of chrysin against cyclophosphamide (CP)-induced testicular toxicity in rats across several parameters, including hormones, oxidative stress, inflammation, apoptosis, and protein expression. Rats were pretreated with oral doses of chrysin at 25, 50, or 100 mg/kg daily for 7 days. On the 8th day, all groups except controls received CP (200 mg/kg) injection. Chrysin doses continued for 7 more days. Hormones, oxidative stress markers, inflammatory cytokines, apoptosis r… Show more
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