Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1

Shi, Hezhan; Hou, Bo; Li, Huifeng; Zhou, Hui; Du, Bin

doi:10.3389/fphar.2022.839464

Cited by 22 publications

(21 citation statements)

References 36 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although cyclophosphamide (CTX) was not recommended in the treatment of RA, it was still the choice for cutaneous vasculitis accompanied by RA. In 2022, Shi et al found that CTX could increase LIP and induce ferroptosis by upregulating heme oxygenase 1 (HMOX-1) expression in glioblastoma cells and breast cancer cells, as well as in vivo (85). In the same year, other researchers proposed an alternative idea that CTX may lead to GPX4 degradation, which in turn leads to caspase-independent parthanatos rather than lipid peroxidation-mediated ferroptosis in human leukemia cell lines, which provided new perspectives on the role of GPX4 beyond ferroptosis (81).…”

Section: Disease-modifying Anti-rheumatic Drugsmentioning

confidence: 99%

Ferroptosis in inflammatory arthritis: A promising future

Chang

Tang²,

Zhang³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

Ferroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid peroxidation, which is characterized by mitochondrial morphological changes and has a complex regulatory network. Ferroptosis has been gradually emphasized in the pathogenesis of inflammatory arthritis. In this review, we summarized the relevant research on ferroptosis in various inflammatory arthritis including rheumatoid arthritis (RA), osteoarthritis, gout arthritis, and ankylosing spondylitis, and focused on the relationship between RA and ferroptosis. In patients with RA and animal models of RA, there was evidence of iron overload and lipid peroxidation, as well as mitochondrial dysfunction that may be associated with ferroptosis. Ferroptosis inducers have shown good application prospects in tumor therapy, and some anti-rheumatic drugs such as methotrexate and sulfasalazine have been shown to have ferroptosis modulating effects. These phenomena suggest that the role of ferroptosis in the pathogenesis of inflammatory arthritis will be worth further study. The development of therapeutic strategies targeting ferroptosis for patients with inflammatory arthritis may be a promising future.

show abstract

Section: Disease-modifying Anti-rheumatic Drugsmentioning

confidence: 99%

Ferroptosis in inflammatory arthritis: A promising future

Chang

Tang²,

Zhang³

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Inhibition of nitrogen fixation 1 (NFS1), which provides sulfur from cysteine for the synthesis of iron-sulfur clusters, activates the iron starvation response by simultaneously increasing transferrin receptor (TFRC) expression and degrading ferritin heavy chain 1 (FTH1), causing an increase in free iron ions, thereby making cells sensitive to ferroptosis activator ( 53 – 55 ). Overactivated heme oxygenase 1 increases intracellular free iron content and enhances ferroptosis effect by degrading hemoglobin into free iron, biliverdin, and carbon monoxide ( 56 – 58 ). Nuclear receptor coactivator 4 (NCOA4) recognizes intracellular after ferritin recognition, and ferritin transfers stored ferric ions to the autophagosome for degradation, which, in turn, releases ferric ions into the cytoplasm to become free iron, a process also known as iron autophagy ( 59 , 60 ).…”

Section: Ferroptosismentioning

confidence: 99%

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Zhang

Liu

2022

Front. Immunol.

View full text Add to dashboard Cite

Ovarian cancer (OC) is one of the most common malignancies that causes death in women and is a heterogeneous disease with complex molecular and genetic changes. Because of the relatively high recurrence rate of OC, it is crucial to understand the associated mechanisms of drug resistance and to discover potential target for rational targeted therapy. Cell death is a genetically determined process. Active and orderly cell death is prevalent during the development of living organisms and plays a critical role in regulating life homeostasis. Ferroptosis, a novel type of cell death discovered in recent years, is distinct from apoptosis and necrosis and is mainly caused by the imbalance between the production and degradation of intracellular lipid reactive oxygen species triggered by increased iron content. Necroptosis is a regulated non-cysteine protease–dependent programmed cell necrosis, morphologically exhibiting the same features as necrosis and occurring via a unique mechanism of programmed cell death different from the apoptotic signaling pathway. Pyroptosis is a form of programmed cell death that is characterized by the formation of membrane pores and subsequent cell lysis as well as release of pro-inflammatory cell contents mediated by the abscisin family. Studies have shown that ferroptosis, necroptosis, and pyroptosis are involved in the development and progression of a variety of diseases, including tumors. In this review, we summarized the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of OC.

show abstract

“…In gastrointestinal cancer, HO-1 expression in colorectal tumor cells was significantly higher than in normal cells, and an HO inhibitor increased chemotherapeutic sensitivity [ 46 ]. Recently, ferroptosis, a new form of programmed cell death regulated by iron accumulation [ 53 ], has been paid attention to, because several chemotherapeutic agents have been shown to induce ferroptosis in cancer cells [ 54 , 55 ]. The major intracellular iron source is the HO reaction; therefore, inducible HO-1 is an important enzyme, changing the intracellular iron distribution and leading to iron-dependent lipid peroxidation during ferroptotic cell death.…”

Section: Role Of Ho-1 In Protecting the Gastrointestinal Tract Agains...mentioning

confidence: 99%

“…HO-1 acts as a critical mediator in the induction of ferroptosis by operating cellular iron levels [ 56 ]. HO-1-mediated induction of ferroptosis suggested a novel chemotherapeutic strategy for cancer treatment [ 55 , 57 ].…”

Section: Role Of Ho-1 In Protecting the Gastrointestinal Tract Agains...mentioning

confidence: 99%

Role of Heme Oxygenase in Gastrointestinal Epithelial Cells

Akagi

2022

Antioxidants

View full text Add to dashboard Cite

The gastrointestinal tract is a unique organ containing both vascular and luminal routes lined by epithelial cells forming the mucosa, which play an important role in the entry of nutrients and act as a selective barrier, excluding potentially harmful agents. Mucosal surfaces establish a selective barrier between hostile external environments and the internal milieu. Heme is a major nutritional source of iron and is a pro-oxidant that causes oxidative stress. Heme oxygenases (HOs) catalyze the rate-limiting step in heme degradation, resulting in the formation of iron, carbon monoxide, and biliverdin, which are subsequently converted to bilirubin by biliverdin reductase. In gastrointestinal pathogenesis, HO-1, an inducible isoform of HO, is markedly induced in epithelial cells and plays an important role in protecting mucosal cells. Recent studies have focused on the biological effects of the products of this enzymatic reaction, which have antioxidant, anti-inflammatory, and cytoprotective functions. In this review, the essential roles of HO in the gastrointestinal tract are summarized, focusing on nutrient absorption, protection against cellular stresses, and the maintenance and regulation of tight junction proteins, emphasizing the potential therapeutic implications. The biochemical basis of the potential therapeutic implications of glutamine for HO-1 induction in gastrointestinal injury is also discussed.

show abstract

Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1

Cited by 22 publications

References 36 publications

Ferroptosis in inflammatory arthritis: A promising future

Ferroptosis in inflammatory arthritis: A promising future

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Role of Heme Oxygenase in Gastrointestinal Epithelial Cells

Contact Info

Product

Resources

About