Cyclopiazonic acid inhibits mutagenic action of aflatoxin B1

Kuilman-Wahls, Mariella E.M.; Vilar, Monica Sabater; Nijs-Tjon, Lilian de; Maas, R.F.M.; Fink‐Gremmels, Johanna

doi:10.1016/s1382-6689(01)00119-3

Cited by 12 publications

(3 citation statements)

References 31 publications

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“…Cyclopiazonic acid (CPA) is an indole-tetramic acid toxic to a variety of animals and has also been implicated in human poisoning (Luk et al 1977 ; Rao and Husain 1985 ; Antony et al 2003 ). Toxic effects include: liver degeneration and necrosis, myocardial lesions, decreased weight gain, vomiting, kidney lesions, pancreas, spleen and several neurotoxic symptoms (Kuilman-Wahls et al 2002 ; Duran et al 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and toxigenic potential ofAspergillussectionFlavion wheat and sorghum silages in Uruguay

Palacio

Pan

2020

Mycology

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Species belonging to Aspergillus section Flavi occur naturally in crops and can cause food spoilage and/or toxin production. The aim of this study was to determine the occurrence and diversity of the species of Aspergillus section Flavi found in wheat and sorghum at harvest time and during silage storage, and to evaluate the toxigenic potential of the isolates to determine the contamination risk of mycotoxins in grains. Strains from Aspergillus flavus and Aspergillus parasiticus were found based on multi-gene phylogenetic analyses. This is the first report on the presence of A. parasiticus in wheat from Uruguay. Of the 80 isolates Aspergillus section Flavi, 30% produced aflatoxins (AFs), mainly type B1, and 25% produced cyclopiazonic acid (CPA). Within the isolates from wheat samples, 35% were AFs producers and 27.5% were CPA producers. Among the Aspergillus section Flavi isolates from sorghum, 25% were AFs producers while 22.5% were CPA producers. This work contributes to the knowledge of the species in crops and helps define appropriate strategies for the prevention and control of contamination with AFs and CPA by Aspergillus section Flavi fungi.

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Section: Introductionmentioning

confidence: 99%

Occurrence and toxigenic potential ofAspergillussectionFlavion wheat and sorghum silages in Uruguay

Palacio

Pan

2020

Mycology

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“…In association with other mycotoxins, the mutagenic and cell viability effects of aflatoxins have been frequently questioned. Nearly all the papers addressing mutagenic activity of these mycotoxin combinations referred to the well-known Ames test using Salmonella Typhimurium strains TA 100 and TA 98 (Sedmikova et al, 2001;Kuilman-Wahls et al, 2002;Vilar et al, 2003). However, a bioluminescence test using the marine bacterium Photobacterium phosphoreum strain NCMB 844 was also proposed (Yates et al, 1987).…”

Section: Aflatoxins and Other Mycotoxinsmentioning

confidence: 99%

“…All the studies reported for the combined toxicity of aflatoxins and CPA or CIT defined their reference point using the arithmetic definition of additivity. Following metabolic activation by either human S-9 mix or rat S-9 mix, the mutagenic activity of AFB1 and CPA combination assessed by reverse mutation of S. Typhimurium TA 98 and TA 100 strains constantly resulted in a reduction compared to AFB1individual effect (Kuilman-Wahls et al, 2002;Vilar et al, 2003). This reduction of the AFB1 mutagenicity by CPA was attributed to the inhibitory effect of CPA on cytochrome P450 (CYP450) 3A4 activity.…”

Section: Combined Toxicity Of Aflatoxins and Other Mycotoxins From Aspergillus Speciesmentioning

confidence: 99%

Mycotoxins co-contamination: Methodological aspects and biological relevance of combined toxicity studies

Alassane-Kpémbi

Schatzmayr²,

Ţăranu

et al. 2017

Critical Reviews in Food Science and Nutrition

233

137

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Mycotoxins are secondary fungal metabolites produced mainly by Aspergillus, Penicillium, and Fusarium. As evidenced by large-scale surveys, humans and animals are simultaneously exposed to several mycotoxins. Simultaneous exposure could result in synergistic, additive or antagonistic effects. However, most toxicity studies addressed the effects of mycotoxins separately. We present the experimental designs and we discuss the conclusions drawn from in vitro experiments exploring toxicological interactions of mycotoxins. We report more than 80 publications related to mycotoxin interactions. The studies explored combinations involving the regulated groups of mycotoxins, especially aflatoxins, ochratoxins, fumonisins, zearalenone and trichothecenes, but also the "emerging" mycotoxins beauvericin and enniatins. Over 50 publications are based on the arithmetic model of additivity. Few studies used the factorial designs or the theoretical biology-based models of additivity. The latter approaches are gaining increased attention. These analyses allow determination of the type of interaction and, optionally, its magnitude. The type of interaction reported for mycotoxin combinations depended on several factors, in particular cell models and the tested dose ranges. However, synergy among Fusarium toxins was highlighted in several studies. This review indicates that well-addressed in vitro studies remain valuable tools for the screening of interactive potential in mycotoxin mixtures.

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Mycotoxins and alimentary mycotoxicoses

Chu¹

2006

Foodborne Infections and Intoxications

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Cyclopiazonic acid inhibits mutagenic action of aflatoxin B1

Cited by 12 publications

References 31 publications

Occurrence and toxigenic potential ofAspergillussectionFlavion wheat and sorghum silages in Uruguay

Occurrence and toxigenic potential ofAspergillussectionFlavion wheat and sorghum silages in Uruguay

Mycotoxins co-contamination: Methodological aspects and biological relevance of combined toxicity studies

Mycotoxins and alimentary mycotoxicoses

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