Cycloprodigiosin up-regulates inducible nitric oxide synthase gene expression in hepatocytes stimulated by interleukin-1β

Teshima, Shigeru; Nakanishi, Hideki; Kamata, Keiko; Kaibori, Masaki; Kwon, A‐Hon; Kamiyama, Yasuo; Nishizawa, Mikio; Ito, Seiji; Okumura, Tadayoshi

doi:10.1016/j.niox.2004.07.009

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…This inhibition of the NF-κB pathway confers both immunosuppressant and anti-tumor effects [69]. Cycloprodigiosin was also shown to stimulate nitric oxide production, improving the cell status by regulating the expression of NF-κB-dependent genes, such as inducible nitric oxide synthase (iNOS) [70]. Both suppression of NF-κB (an important transcription factor regulating inflammatory response) and increased NO production have been suggested as an anti-inflammatory strategy in inflammatory bowel disease (IBD) and in rheumatoid arthritis (AR).…”

Section: Marine Natural Products: a Potential Immunomodulating Andmentioning

confidence: 99%

Marine Bioactives and Potential Application in Sports

et al. 2014

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An enriched diet with antioxidants, such as vitamin E, vitamin C, β-carotene and phenolic compounds, has always been suggested to improve oxidative stress, preventing related diseases. In this respect, marine natural product (MNP), such as COX inhibitors, marine steroids, molecules interfering with factors involved in the modulation of gene expression (such as NF-κB), macrolides, many antioxidant agents, thermogenic substances and even substances that could help the immune system and that result in the protection of cartilage, have been recently gaining attention. The marine world represents a reserve of bioactive ingredients, with considerable potential as functional food. Substances, such as chitin, chitosan, n-3 oils, carotenoids, vitamins, minerals and bioactive peptides, can provide several health benefits, such as the reduction of cardiovascular diseases, anti-inflammatory and anticarcinogenic activities. In addition, new marine bioactive substances with potential anti-inflammatory, antioxidant and thermogenic capacity may provide health benefits and performance improvement, especially in those who practice physical activity, because of their increased free radical and Reacting Oxygen Species (ROS) production during exercise, and, particularly, in athletes. The aim of this review is to examine the potential pharmacological properties and application of many marine bioactive substances in sports.

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Section: Marine Natural Products: a Potential Immunomodulating Andmentioning

confidence: 99%

Marine Bioactives and Potential Application in Sports

et al. 2014

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“…It is also an immunosuppressant agent because of its action as a selective inhibitor of T cell proliferation, like other members of the prodigiosin family [71]. Cycloprodigiosin also stimulates nitric oxide production during hepatic injury, improving cell status by regulating the expression of NF-κB-dependent genes, such as inducible Nitric Oxide Synthase (iNOS) [72], Considering that immunosuppressive drugs such as corticosteroids and mesalazine can prevent the activation of NF-kappaB, both the suppression of NF-κB and increased NO production have been suggested as an anti-inflammatory strategy in inflammatory bowel disease (IBD), so that administration of cycloprodigiosine may limit chronic inflammation [73]. Since NF-κB is known to be a transcription factor regulating inflammatory response genes and implicated in AR, its inhibition could also indicate anti-inflammatory and anti-arthritic properties possessed by cycloprodigiosin [74].…”

Section: Biology Of Marine Natural Products: a Potential Anti-inflmentioning

confidence: 99%

Marine Bioactives: Pharmacological Properties and Potential Applications against Inflammatory Diseases

et al. 2012

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Inflammation is a hot topic in medical research, because it plays a key role in inflammatory diseases: rheumatoid arthritis (RA) and other forms of arthritis, diabetes, heart diseases, irritable bowel syndrome, Alzheimer’s disease, Parkinson’s disease, allergies, asthma, even cancer and many others. Over the past few decades, it was realized that the process of inflammation is virtually the same in different disorders, and a better understanding of inflammation may lead to better treatments for numerous diseases. Inflammation is the activation of the immune system in response to infection, irritation, or injury, with an influx of white blood cells, redness, heat, swelling, pain, and dysfunction of the organs involved. Although the pathophysiological basis of these conditions is not yet fully understood, reactive oxygen species (ROS) have often been implicated in their pathogenesis. In fact, in inflammatory diseases the antioxidant defense system is compromised, as evidenced by increased markers of oxidative stress, and decreased levels of protective antioxidant enzymes in patients with rheumatoid arthritis (RA). An enriched diet containing antioxidants, such as vitamin E, vitamin C, β-carotene and phenolic substances, has been suggested to improve symptoms by reducing disease-related oxidative stress. In this respect, the marine world represents a largely untapped reserve of bioactive ingredients, and considerable potential exists for exploitation of these bioactives as functional food ingredients. Substances such as n -3 oils, carotenoids, vitamins, minerals and peptides provide a myriad of health benefits, including reduction of cardiovascular diseases, anticarcinogenic and anti-inflammatory activities. New marine bioactives are recently gaining attention, since they could be helpful in combating chronic inflammatory degenerative conditions. The aim of this review is to examine the published studies concerning the potential pharmacological properties and application of many marine bioactives against inflammatory diseases.

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“…Two signaling pathways, the activation of NF-jB (its translocation from the cytoplasm to the nucleus, and DNA binding) through the degradation of IjB and the upregulation of IL-1RI through the activation of phosphatidylinositol 3-kinase (PI3K)/Akt, are essential for iNOS induction [20,21,39,40]. IL-1b stimulates the degradation of IjB proteins, which is followed by the activation of NF-jB.…”

Section: Effects Of Sivelestat On the Activation Of Nf-jb And Upregulmentioning

confidence: 99%

Sivelestat Suppresses iNOS Gene Expression in Proinflammatory Cytokine-Stimulated Hepatocytes

et al. 2011

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Cycloprodigiosin up-regulates inducible nitric oxide synthase gene expression in hepatocytes stimulated by interleukin-1β

Cited by 5 publications

References 36 publications

Marine Bioactives and Potential Application in Sports

Marine Bioactives and Potential Application in Sports

Marine Bioactives: Pharmacological Properties and Potential Applications against Inflammatory Diseases

Sivelestat Suppresses iNOS Gene Expression in Proinflammatory Cytokine-Stimulated Hepatocytes

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