2005
DOI: 10.1002/chin.200519207
|View full text |Cite
|
Sign up to set email alerts
|

Cyclopropanation of Betulin and Its Diacetate with Dihalocarbenes.

Abstract: Steroids U 0300 Cyclopropanation of Betulin and Its Diacetate with Dihalocarbenes. -The title reaction follows the [1 + 2] cycloaddition pattern leading to adducts of type (III), (VII), and (IX). -(KOMISSAROVA, N. G.; BELENKOVA, N. G.; SHITIKOVA, O. V.; SPIRIKHIN, L. V.; YUNUSOV, M. S.; Russ.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
2
0

Year Published

2008
2008
2021
2021

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
(2 citation statements)
references
References 1 publication
0
2
0
Order By: Relevance
“…[31][32][33][34][35][36][37][38][39][40][41][42][43][44] Among these there are mostly Anelli [31][32][33][34][35][36] and Jones [31,34,[37][38][39][40][41][42][43] type oxidations employed, both coming along with several drawbacks. In particular, the Jones oxidation and related transformations suffer from the use of highly toxic/mutagenic chemicals and a poor discrimination between the primary and the secondary alcohol moieties, [31,34,[37][38][39][40][41][42][43] whereas N-oxyl radical-mediated oxidation frequently employs expensive terminal oxidizers [36] and co-catalysts [32] or reagents incompatible with the betulin 20(29)double bond (namely bleach). [31,[33][34][35] Moreover, the excessive usage of those reagents leads to tedious workup procedures to ensure removal of reagent traces and byproducts and creates large amounts of waste.…”
Section: Resultsmentioning
confidence: 99%
“…[31][32][33][34][35][36][37][38][39][40][41][42][43][44] Among these there are mostly Anelli [31][32][33][34][35][36] and Jones [31,34,[37][38][39][40][41][42][43] type oxidations employed, both coming along with several drawbacks. In particular, the Jones oxidation and related transformations suffer from the use of highly toxic/mutagenic chemicals and a poor discrimination between the primary and the secondary alcohol moieties, [31,34,[37][38][39][40][41][42][43] whereas N-oxyl radical-mediated oxidation frequently employs expensive terminal oxidizers [36] and co-catalysts [32] or reagents incompatible with the betulin 20(29)double bond (namely bleach). [31,[33][34][35] Moreover, the excessive usage of those reagents leads to tedious workup procedures to ensure removal of reagent traces and byproducts and creates large amounts of waste.…”
Section: Resultsmentioning
confidence: 99%
“…( 1 H-1 H COSY and 13 C-1 H correlations) of the oxidative decarboxylation products and also of compounds described earlier [5][6][7][8][9][10], allowed us to make the unambiguous and full assignment of all carbon and hydrogen atom signals in these spectra and to reveal a criterion for the determination of the stereochemistry of the C-17 atom, which are complementary. One of the criteria is the value of the chemical shift of the C-13 signal.…”
mentioning
confidence: 96%