Cyclosporin in Pulmonary Sarcoidosis

Established and experimental medical therapy of pulmonary sarcoidosis

“…In some case reports, it was felt to be effective for refractory disease [156]. In a double-blind, randomised trial of chronic pulmonary sarcoidosis, WYSER et al [22] found no significant additional benefit for adding cyclosporin A to prednisone therapy in terms of either pulmonary function or steroid sparing.…”

Effective use of cyclosporin in sarcoidosis: a treatment strategy based on computed tomography scanning

“…Where doses were cited, objective improvement was seen in all five cases, including our own, treated with a high dose range (150-500 ng·ml -1 ) [1,5], but in only 2/16 cases treated with a low dose range (100-200 ng·ml -1 ) [2,4,8]. The dose required to prevent activation of T-cells is lower than that required to inhibit previously activated T-cells.…”

“…In 12 patients, a fall in bronchoalveolar lavage lymphocyte count occurred. In two cases, life-threatening endobronchial lesions regressed only with cyclosporin [1,2].…”

“…[1][2][3][4][5][6][7][8]. There are good theoretical reasons for evaluating the use of cyclosporin in sarcoidosis [8].…”

Low dose cyclosporin a therapy in chronic posterior uveitis

“…Both patients who had ocular sarcoidosis in this series demonstrated improvement in visual acuity and control of intraocular inflam mation which contrasts with the lack of efficacy of CsA noted in pulmonary sarcoidosis. 25 No patient in our study has discontinued CsA therapy because of toxicity, although the dosage has required modification. The fre quency of relapse remains to be established on cessation of therapy and several patients are now tailing off by monthly decrements of 50 mg. Binder et at.…”