1983
DOI: 10.1016/s0140-6736(83)91558-1
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Cyclosporin Prevents Diabetes in Bb Wistar Rats

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Cited by 183 publications
(58 citation statements)
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“…Cyclosporine, with its specific immunomQtfularory action (13)(14)(15) and TABLE 1 its efficacy and relat ive safety in comparison to other immu nosu ppressivc agents, particularly in organ t ransplantation ( 15,16), and its effective prevention of autoimmunity in an imal models ( 17,18), has prompted its experimental use in a series of autoimmu ne d isease:, in man ( 19), including Croh n 's disease. Preliminary stud ies with Crohn's disease have been encouraging (20)(21)(22).…”
Section: Rohn's D Isease Is a Chronicmentioning
confidence: 99%
“…Cyclosporine, with its specific immunomQtfularory action (13)(14)(15) and TABLE 1 its efficacy and relat ive safety in comparison to other immu nosu ppressivc agents, particularly in organ t ransplantation ( 15,16), and its effective prevention of autoimmunity in an imal models ( 17,18), has prompted its experimental use in a series of autoimmu ne d isease:, in man ( 19), including Croh n 's disease. Preliminary stud ies with Crohn's disease have been encouraging (20)(21)(22).…”
Section: Rohn's D Isease Is a Chronicmentioning
confidence: 99%
“…2 The nonobese diabetic (NOD) mouse, derived from the CTS subline of an ICR strain, is an animal model of type I diabetes characterized by insulitis 9 and a perturbed immune system. 10^12 Ultrastructural examinations of female NOD mice show infiltration of macrophages and lymphocytes into the islets and reduction of islet size.…”
mentioning
confidence: 99%
“…The possibility by a number of techniques, to modulate or alter the immune response to decrease the incidence of diabetes in the spontaneously diabetic BB rat [45] have further stimulated efforts to carry out early immune intervention in man. Since cyclosporin A was found to decrease the incidence of diabetes in the BB rat [84], this drug was tested in an open study in man [85]. In this study some patients were not only able to discontinue their insulin therapy but their course of endogenous insulin production showed some increase compared with other patient populations.…”
Section: Future Studies: Possible Ways Of Preventing Diabetesmentioning
confidence: 99%