Cyclosporine bone remodeling effect prevents steroid osteopenia after kidney transplantation

Westeel, François P.; Mazouz, Hakim; Ezaitouni, F.; Hottelart, C; Ivan, Christina; Fardellone, Patrice; Brazier, Michel; Esper, I. El; Petit, Jacques; Achard, Jean Michel; Pruna, A; Fournier, A

doi:10.1046/j.1523-1755.2000.00341.x

Cited by 64 publications

(28 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cyclosporine treatment increases bone turnover and is associated with increased plasma concentrations of bone formation and resorption markers (48,49). Indeed, during remission, the concentrations of osteocalcin and NTx were significantly higher compared with those in relapse.…”

Section: Discussionmentioning

confidence: 99%

Increased Osteoblastic Activity and Expression of Receptor Activator of NF-κB Ligand in Nonuremic Nephrotic Syndrome

Freundlich¹,

Alonzo²,

Bellorín-Font³

et al. 2005

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Patients with nephrotic syndrome (NS), even with normal GFR, often display altered mineral homeostasis and abnormal bone histology. However, the latter, mostly osteomalacia and increased bone resorption, cannot be readily explained by the prevalent concentrations of parathyroid hormone and vitamin D metabolites. The transmembrane receptor activator of NF-B ligand (RANKL) of osteoblasts is essential for osteoclast formation and differentiation. Osteoblasts activity and the expression of RANKL were tested in cultures of normal human osteoblasts with sera obtained from patients with NS and normal GFR (129 ؎ 26 ml/min per 1.73 m 2 ) during relapse and remission of their NS. Osteoblasts that were cultured in vitro with sera during relapse displayed elevated concentrations of alkaline phosphatase (AP) and increased expression of RANKL. By contrast, during remission, AP concentrations were significantly lower (P < 0.05) and RANKL expression notably attenuated or absent. AP correlated with the proteinuria (r ‫؍‬ 0.5, P < 0.05) and was not significantly affected by the therapeutic administration of corticosteroids. Whereas parathyroid hormone levels were normal (35 ؎ 21 pg/ml), the serum markers of bone formation (osteocalcin and bone-specific alkaline phosphatase) were lower during relapse compared with remission. Thus, sera from patients with NS and normal GFR stimulate the activity of osteoblasts and upregulate their expression of RANKL. These alterations, more prominent during clinically active NS, are transient and reversible upon remission. These disturbances of bone biology may play an important pathogenic role in the abnormal bone histology observed in patients with NS even before a decline in GFR occurs.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Osteoblastic Activity and Expression of Receptor Activator of NF-κB Ligand in Nonuremic Nephrotic Syndrome

Freundlich¹,

Alonzo²,

Bellorín-Font³

et al. 2005

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…The effect of cyclosporine on calcium metabolism, however, is rather controversial. Cyclosporine has been suggested to work beneficially, with its steroidsparing effect, in bone remodeling through increasing serum concentrations of 1,25-(OH)2-vitamin D and a bone formation marker, osteocalcin (15,16). Another study showed no significant effect on calcium-regulating hormones and bone remodeling in normocalcemic renal transplant recipients with good renal functions (17).…”

Section: Discussionmentioning

confidence: 99%

Liver Transplantation-associated Hypercalcemia Followed by Acute Renal Dysfunction

Shirasawa

Nomura²,

Yoshida

et al. 2004

Intern. Med.

View full text Add to dashboard Cite

A 34-year-old woman with liver insufficiency due to glycogen storage disease III underwent a living spousal liver transplantation. Soon after the successful operation, moderate hypercalcemia along with hyperbilirubinemia emerged without clarified reasons. The hypercalcemia persisted for over a month despite calcitonin treatment and the serum calcium level surged to 13.2 mg/dl with albumin correction. Renal dysfunction was indicated by an acute increase in serum creatinine ( 0.8 to 2.8 mg/ml), which was assumed to be hypercalcemia-induced and was effectively treated with bisphosphonate, pamidronate (

show abstract

“…Os estudos existentes avaliaram um número pequeno de pacientes, não foram desenhados para investigar os efeitos dos imunossupressores sobre o tecido ósseo e apresentam resultados contraditórios. [35][36][37] A ação da rapamicina no tecido ósseo também é pouco conhecida. Estudo recente mostra o papel da rapamicina estimulando a proliferação de osteoblastos, entretanto; estes achados divergem com os de outros autores.…”

Section: Racionalunclassified

Distúrbio mineral e ósseo após o transplante renal

Gueiros¹,

Neves²,

Sampaio³

et al. 2011

J. Bras. Nefrol.

View full text Add to dashboard Cite

Cyclosporine bone remodeling effect prevents steroid osteopenia after kidney transplantation

Cited by 64 publications

References 42 publications

Increased Osteoblastic Activity and Expression of Receptor Activator of NF-κB Ligand in Nonuremic Nephrotic Syndrome

Increased Osteoblastic Activity and Expression of Receptor Activator of NF-κB Ligand in Nonuremic Nephrotic Syndrome

Liver Transplantation-associated Hypercalcemia Followed by Acute Renal Dysfunction

Distúrbio mineral e ósseo após o transplante renal

Contact Info

Product

Resources

About