Cyclosporine in generalized bullous-fixed drug eruption

Beniwal, Ranjana; Gupta, Lalit; Khare, Ashok Kumar; Mittal, Asit; Mehta, Sharad; Balai, Manisha

doi:10.4103/ijd.ijd_458_17

Cited by 7 publications

(10 citation statements)

References 6 publications

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“…In this case, cyclosporine was initiated due to the patient's rapidly progressive blistering, severe pain, and extensive body surface area involvement (28%). Cyclosporine was chosen over continuing the prednisone as multiple GBFDE studies have shown that cyclosporine results in rapid cessation of blistering, re-epithelialization of skin, and resolution of lesions with minimal changes in pigmentation [ 11 , 12 , 14 , 22 ]. Due to its minimal side effects when used acutely and the direct mechanism of inhibiting T-cell activation, it has been suggested to be a therapeutic agent for treating FDE superior to prednisone and intravenous immunoglobulin [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…A further literature search identified 5 adult cases of GBFDE treated with cyclosporine, but no paediatric cases (Table 1 ) [ 11 , 12 , 13 , 14 ]. Variable dosages (100 mg/day, 2 mg/kg/day, or 5 mg/kg/day), routes of administration (oral or intravenous), and durations (5–7 days) were used, reflecting both the heterogeneity of institutional and practitioner preferences and the lack of evidence for use in GBFDE.…”

Section: Discussionmentioning

confidence: 99%

“…The literature suggests a potential response to systemic therapies including intravenous steroids and immunoglobulin [ 10 ]. Five cases of GBFDE in adult patients also demonstrate a benefit from systemic cyclosporine [ 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Severe Generalized Bullous Fixed Drug Eruption Treated with Cyclosporine: A Case Report and Literature Review

et al. 2021

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Generalized bullous fixed drug eruptions (GBFDEs) are rare in the paediatric population. We present the case of a 7-year-old girl with GBFDE believed to be secondary to oral ibuprofen, who experienced rapid resolution of lesions and cessation of blistering with a 3-week course of oral cyclosporine. To the best of our knowledge, this is the first report of a paediatric case of GBFDE treated with cyclosporine. In our report, we review published cases of GBFDE in children, and all adult cases managed with cyclosporine.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Severe Generalized Bullous Fixed Drug Eruption Treated with Cyclosporine: A Case Report and Literature Review

et al. 2021

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“…The usefulness of granulysin to distinguish both entities has been described, since serum and tissue levels are lower in GBFDE. 1,4 Cyclosporine acts by inhibiting the dephosphorylation of the nuclear factor of activated T cells, generating a reduction of IL-2 and thus an inhibition of the response of CD4+ and CD8+ lymphocytes. These latter are the principal mediators of FDE.…”

mentioning

confidence: 99%

“…5 Thus, cyclosporine is an excellent therapeutic option for this rare and lethal variant but it has scarcely been reported in the literature. 4,5 Future studies are…”

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confidence: 99%