Cyclosporine Neurotoxicity

Hauben, Manfred

doi:10.1002/j.1875-9114.1996.tb03639.x

Cited by 75 publications

(1 citation statement)

References 44 publications

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“…Cyclosporine-induced neurotoxicity is a well-known side effect and, in particular, can induce psychosis. [61][62][63][64][65] Everolimus, also an immunosuppressant, is a drug that acts on the mechanistic target of rapamycin and that affects the growth of neural stem cells. 66 A case study has been reported in which everolimus also induced psychosis, 67 but in a previous study, the use of everolimus in children and adolescents with tuberous sclerosis resulted in a decrease in prepulse inhibition, an indicator of psychosis and sensorimotor gating.…”

Section: Discussionmentioning

confidence: 99%

Target Discovery Using Deep Learning-Based Molecular Docking and Predicted Protein Structures With AlphaFold for Novel Antipsychotics

Kim

Kim²

2023

Psychiatry Investig

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Objective New drugs are needed to treat antipsychotic-resistant schizophrenia, especially those with clozapine-resistant schizophrenia. Atypical antipsychotics have predominantly 5-HT2A and dopaminergic antagonism, but also require investigation of other receptors.Methods In this study, the binding affinities between clozapine, olanzapine, and quetiapine with neuropharmacological, immunological, and metabolic receptors were measured using GNINA (Deep Learning Based Molecular Docking) and AlphaFold (Predicted Protein Structures).Results Through this study, it was determined that these antipsychotics showed high binding affinity to a variety of receptors, such as CB2, 5-HT1BR, NPYR4, and CCR5. Cyclosporin A and everolimus which show high affinities with those receptors could be used for the development of new antipsychotic drugs based on these drugs.Conclusion In the future, the method used in this study will be applied to the development of new antipsychotic drugs, including drug repositioning, and to the discovery of the pathophysiology of schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Target Discovery Using Deep Learning-Based Molecular Docking and Predicted Protein Structures With AlphaFold for Novel Antipsychotics

Kim

Kim²

2023

Psychiatry Investig

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Long‐Term Nutritional and Neurodevelopmental Outcome of Liver Transplantation in Infants Aged Less Than 12 Months

van Mourik,

Beath,

Brook

et al. 2000

J. pediatr. gastroenterol. nutr.

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Background:Liver transplantation is established treatment for children with end‐stage liver disease and has a 5‐year survival rate of 80% to 85%, even in infants under 12 months. Long‐term outcome in nutritional rehabilitation and normal development is unknown. This study aimed to prospectively evaluate growth and psychoneurologic performance of children who undergo liver transplantation in infancy.Methods:Twenty‐five infants (18 girls, 7 boys) who underwent liver transplantation at less than 12 months of age (median age, 9 months) were evaluated for 4 years. Growth measurements were expressed as standard deviation scores (SDSs; mean ± SEM), and psychoneurologic performance was assessed with the unrevised Griffiths Mental Ability Scales (normal range, 80–120).Results:Four children died during the study (4‐year survival, 84%). The children were malnourished before transplantation (SDSs: weight, −1.9 ± 0.2; midarm muscle area, −0.93 ± 0.3; midarm fat area, −1.52 ± 0.3; and height, −0.95 ± 0.3). Nutritional rehabilitation for all parameters occurred within 12 to 24 months after transplantation, which was most significant for weight (−1.1 ± 0.2, P = 0.001), midarm muscle area (0.74 ± 0.3, P = 0.001), and midarm fat area (−0.44 ± 0.3, P = 0.01). There was some improvement in height (−0.72 ± 0.3, P = 0.14), which was not significant, although infants who were severely stunted before transplantation (mean height standard deviation score [SDS] −2.46) showed significant catch‐up at 1 year after transplantation (mean height SDS −1.2, P = 0.003). Psychoneurologic scores were within normal limits before transplantation and were maintained for the 4‐year follow‐up period, although individual scores varied during this period. Improved nutritional status was associated with increased muscle bulk and subsequent improvement in motor scores from 90.6 at initial assessment to 97.3 at 4 years (P = 0.28). There was a temporary reduction in social skills and eye–hand coordination in the first year, which may have been an effect of the hospital environment or cyclosporine immunosuppression. Language abilities also regressed during the first year, possibly related to the effect of nasogastric tube feeding in delaying normal speech development.Conclusions:Liver transplantation in infancy has not only a successful outcome but is also associated with long‐term catch‐up growth and nutrition and maintenance of normal development.

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Pomelo enhances cyclosporine bioavailability in healthy male thai volunteers

Anlamlert

Sermsappasuk

Yokubol

et al. 2014

The Journal of Clinical Pharma

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The aim of this study was to investigate the effect of pomelo pulp on the pharmacokinetics of cyclosporine in healthy male Thai volunteers. The study design was an open-label, randomized, single dose, crossover study with a 2-week washout period. A single oral dose of 2 × 100 mg cyclosporine was administered with 200 mL of water. Each subject received 250 g of pomelo pulp or 250 mL of water 1 hour before drug administration and once again 10 minutes following drug administration. Blood samples were collected over a 24 hour period. The point estimates (90% confidence intervals) of the test/control ratio using logarithmic transformed data for the area under the curve (AUC) for blood concentration from time 0 to infinity (AUC(0- ∞)) and the observed maximum concentration (C(max)) were 128.8% (120.6-137.6) and 136.1% (126.0-146.8), respectively. These 90% confidence intervals were higher than the accepted bioequivalence range defined by the European Medicines Agency guidelines for narrow therapeutic index drugs (90%-111% for AUC and 80%-125% for C(max)). However, the apparent terminal half-life (t(1/2)) was not significantly different. In conclusion, co-administration of cyclosporine and pomelo pulp increased the relative bioavailability of cyclosporine.

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Cyclosporine Neurotoxicity

Cited by 75 publications

References 44 publications

Target Discovery Using Deep Learning-Based Molecular Docking and Predicted Protein Structures With AlphaFold for Novel Antipsychotics

Target Discovery Using Deep Learning-Based Molecular Docking and Predicted Protein Structures With AlphaFold for Novel Antipsychotics

Long‐Term Nutritional and Neurodevelopmental Outcome of Liver Transplantation in Infants Aged Less Than 12 Months

Pomelo enhances cyclosporine bioavailability in healthy male thai volunteers

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