Cyclosporine Toxicity Associated With Allopurinol

Sl, Stevens; Mh, Goldman

doi:10.1097/00007611-199212000-00032

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Cited by 11 publications

(1 citation statement)

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“…The interaction may not be widely recognised for this reason 1. Cyclosporin nephrotoxicity may occur with long term implications unless the dose is reduced.…”

mentioning

confidence: 99%

Drug points: Allopurinol interaction with cyclosporin

Gorrie

Beaman²,

Nicholls³

et al. 1994

BMJ

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“…The interaction may not be widely recognised for this reason 1. Cyclosporin nephrotoxicity may occur with long term implications unless the dose is reduced.…”

mentioning

confidence: 99%

Drug points: Allopurinol interaction with cyclosporin

Gorrie

Beaman²,

Nicholls³

et al. 1994

BMJ

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Gout and Organ Transplantation

Stamp

Chapman

2012

Curr Rheumatol Rep

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Acute and chronic gout are common complications following organ transplantation. Risk factors include those shared with the general population (eg, diuretic use) and transplant-specific risk factors (eg, cyclosporine). Clinical features of gout are similar to those seen in the general population, although tophi may be more common. A definitive diagnosis requires demonstration of monosodium urate crystals within synovial fluid or tophi. Treatment is often empiric, although a poor response should prompt joint aspiration to exclude septic arthritis. Corticosteroids are commonly used to treat acute gout due to the adverse profile and drug interactions with NSAIDs and colchicine. Sustained reduction of serum urate (≤6 mg/dL) is critical in long-term management. Allopurinol is the most commonly used agent, although vigilant monitoring is required if combined with azathioprine. Other options include febuxostat and benzbromarone. The role of newer agents such as interleukin-1 inhibitors and uricases remains to be determined. General measures should include minimizing diuretic use.

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Allopurinol

2016

Meyler's Side Effects of Drugs

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Cyclosporine Toxicity Associated With Allopurinol

Cited by 11 publications

References 0 publications

Drug points: Allopurinol interaction with cyclosporin

Drug points: Allopurinol interaction with cyclosporin

Gout and Organ Transplantation

Allopurinol

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