Cyclotron Neutron and γ-Ray Dosimetry for Animal Irradiation Studies

Tochilin, E.; Ross, S.W.; Shumway, B.W.; Kohler, G. D.; Golden, Robert N.

doi:10.2307/3570352

Cited by 30 publications

(4 citation statements)

References 12 publications

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“…Multiplying by the boneto-soft-tissue neutron kerma ratio (at 233 keV, the mean neutron energy) of 0.702 (Caswell et al 1980) results in a neutron dose equivalent per deposited charge (on target) of 0.674 ± 10% mSv/mA-min, for compact (cortical) bone. Furthermore, these authors confirmed the earlier reports that the g dose for this reaction is ~1% of the neutron dose (Tochilin et al 1956;NBS 1957).…”

Section: Materials and Methods;supporting

confidence: 89%

Mechanical and Architectural Changes in Animal Bone Following Fast Neutron Irradiation

Galiano,

Liu,

Ren

et al. 2024

Health Physics

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Damage to healthy bone following exposure to ionizing radiation has been well documented for at least seven decades. Among the reported effects are a transient increase in stiffness and a reduction in breaking strength. These changes have been linked to a decrease in osteoblast proliferation and differentiation, inducing cell cycle arrest, reducing collagen production, and increasing sensitivity to apoptotic agents. In this work, we analyzed some mechanical and structural changes in compact costal bovine bone (Hereford breed, n = 9) subjected to escalating doses of fast neutrons from a 7Li(p,n)7Be reaction. The mean neutron energy was 233 keV with calculated absorbed doses ranging from 0 to 4.05 ± 10% Gy. Samples were subjected to Young’s Modulus (YM) and breaking strength testing with a Universal Testing Machine (UTM). We found an increase in Young’s Modulus and a decrease in breaking strength as functions of increasing dose equivalent. Optical coherence tomography (OCT) revealed trabecular displacement into compact bone in an irradiated sample (D = 4.05 ± 10% Gy), with breaching of the endosteal wall. OCT further revealed a “crack-like” structure across the irradiated sample, potentially consistent with damage from a proton track resulting from an elastic (n,p) reaction. No previous report has been found on mechanical changes in large mammalian bones following fast neutron doses, nor of the OCT imaging of such samples.

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Section: Materials and Methods;supporting

confidence: 89%

Mechanical and Architectural Changes in Animal Bone Following Fast Neutron Irradiation

Galiano,

Liu,

Ren

et al. 2024

Health Physics

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“…First collision dose was calculated from sulfur wafers exposed with each group of animals. The characteristics of this source (Tochilin and Kohler, 1958) and the method of dosimetry (Tochilin, et al, 1956) have been published.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Age at Exposure Upon the Radiation Induced Dental Defect in Rats

Jones¹,

Castanera²,

Kimeldorf³

1963

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“…At age 10-15 weeks old, the mice received a single whole body exposure to fast neutrons (with a spectrum similar to that of fission neutrons), produced in the 60-inch cyclotron at the Crocker Laboratory of the University of California, Berkeley by the Be(pn) B reaction. The irradiation procedure has been described previously (8); and the physical characteristics of these neutrons, as well as the details of dosimetry have been reported by Tochlin et al (16). The dose rate was approximately 30 rad per minute.…”

Section: Materials Anil Methodsmentioning

confidence: 99%