Cyclotron production of 128Cs (3.62 min). A new positron-emitting radionuclide for medical applications

Radionuclides, 2. Radioactive Elements and Artificial Radionuclides

“…The extent of long-lived 67 Ga contamination at EOB is 0.25 %. If the incident energy is increased beyond 18 MeV, the contamination by 67 Ga increases with no significant gain in 66 Ga yield. The yield of 66 Ga at 18 MeV incident energy is about 700 mCi mA À1 h À1 [47].…”

“…66 Ga has replaced other radiogalliums in clinical studies. Accumulation of 67 Ga citrate in soft-tumor tissues has promoted its use for the detection of tumors and inflammatory diseases.…”

“…However, the short half-life of 68 Ga limits its suitability in lengthy procedures, so that longer-lived PET gallium radionuclides have been sought. 66 Ga has a t 1/2 of 9.4 h, and 56.5 % of its decay is by positron emission. It can be produced by a particle bombardment of natural copper via the 63 Cu(a, n) reaction, with a maximum cross section of 667 mbarn at 16.6 MeV.…”

“…Cs in transient equilibrium has yielded 3.1 mCi mA À1 h À1 with a 2.3 g/cm 2 thick CsCl target and a proton energy of 67 MeV. Ion exchange can be used for preparing highly-purified 128 Cs for the production of this generator [66].…”

Investigation of excitation functions of alpha induced reactions on natXe: Production of the therapeutic radioisotope 131Cs

“…Among the reaction products studied here the isotopes 128 Cs and 131 Cs are of interest for medical applications. 128 Cs was already proposed more than 20 years ago by Lagunas-Solar [17] but did not gain real practical interest. A raising interest, however, exists for 131 Cs especially as seed for brachytherapy in prostate cancer treatment.…”