Cyclotron production of carrier-free gallium-67

Hupf, H.B.; Beaver, J.E.

doi:10.1016/0020-708x(70)90014-1

Cited by 40 publications

(4 citation statements)

References 3 publications

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“…Te most common underlying conditions were malignancy (11%), pneumonia (11%), hypertension (9.4%) and cirrhosis (7.9%). In parallel with previous studies, cancer patients are especially susceptible to severe pneumococcal infections, because of their weakened immune systems [27,28]. Cirrhosis is a well-known predisposing factor for IPD and cirrhosis afected 7.9% of the patients in our study.…”

Section: Discussionsupporting

confidence: 88%

Clinical Characteristics, Antimicrobial Resistance, and Outcomes of Patients with Invasive Pneumococcal Disease in Ningxia Hui Autonomous Region, China, 2013–2021

Jia

Wang

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Objectives. This study aimed to analyze the clinical features, antibiotic susceptibility profiles, and outcomes of patients with invasive pneumococcal disease (IPD) at a hospital in Ningxia Hui Autonomous Region, to provide the basis for improving the clinical treatment effect. Methods. Patients with IPD were retrospectively collected from 2013 to 2021. Clinical manifestations, laboratory tests, antimicrobial susceptibility, antibiotic treatment, and outcomes of the disease were analyzed. Results. In this study, we identified 127 IPD cases, of whom 49 (38.6%) had meningitis and 78 (61.4%) had bacteremia. The median ages of pediatric cases and adult cases were 2 years (IQR: 0–5) and 52.5 years (IQR: 35–62), respectively. There were 27 and 45 males in the pediatric and adult groups, and no significant gender difference in the different age groups ( p = 0.584 ) was found. Of 75 cases with underlying diseases, pneumonia (11%), malignancy (11%), hypertension (9.4%), and hepatic cirrhosis (7.9%) were the most common. The incidence of underlying diseases was even higher in the adult group (67.1%) than in the pediatric group (47.1%) ( p = 0.028 ). The frequency of fever, cough, and seizures was significantly higher in the pediatric group than in the adult group, with p -values of 0.004, 0.004, and 0.001, respectively. The percentage of neutrophils in the blood was significantly higher in the adult cases than in the pediatric cases ( p < 0.001 ). Furthermore, there was a significantly higher WBC count ( p < 0.001 ), percentage of neutrophils ( p = 0.012 ), and protein level ( p = 0.019 ) in the CSF samples in the adult patients compared to pediatric patients. The susceptibility rates of S. pneumoniae isolates to vancomycin, linezolid, and levofloxacin were 100%. The susceptibility rates of penicillin were 98.7% and 34.1% in bacteremia and meningitis patients, respectively. Most isolates were resistant to erythromycin, clindamycin, tetracycline, and azithromycin. The most common antibiotic treatment was β-lactams. Seven (5.5%) patients died during hospitalization, and 38 (29.9%) patients' health deteriorated. Conclusion. These results may provide a reference basis for the diagnosis and empiric treatment of IPD in the region.

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Section: Discussionsupporting

confidence: 88%

Clinical Characteristics, Antimicrobial Resistance, and Outcomes of Patients with Invasive Pneumococcal Disease in Ningxia Hui Autonomous Region, China, 2013–2021

Jia

Wang

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Gallium-67 is cyclotron produced by the 68 Zn (p, 2n)− 67 Ga reaction, as illustrated in Figure , in which a thin layer of enriched 68 Zn is electrochemically plated on an appropriate metal target (typically zinc or copper). After irradiation, gallium is dissolved off the target with an appropriate acid (e.g., HCl) and separation along with concentration is achieved by solvent/solvent extraction, ion-exchange chromatography, or extraction chromatography. − In most cases, the radionuclide is obtained in hydrochloric acid solutions of various concentrations. 67 Ga is readily available at reasonable cost (ca.…”

Section: Gallium Radioisotopesmentioning

confidence: 99%

“…After irradiation, gallium is dissolved off the target with an appropriate acid (e.g., HCl) and separation along with concentration is achieved by solvent/solvent extraction, ion-exchange chromatography, or extraction chromatography. [162][163][164][165][166] In most cases, the radionuclide is obtained in hydrochloric acid solutions of various concentrations. 67 Ga is readily available at reasonable cost (ca.…”

Section: Gallium-67mentioning

confidence: 99%

Technetium and Gallium Derived Radiopharmaceuticals: Comparing and Contrasting the Chemistry of Two Important Radiometals for the Molecular Imaging Era

et al. 2010

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“…Esta "reversão" pode atuar tanto no aumento da especificidade da operação de extração, como para retornar a substância de interesse para um meio mais conveniente para purificação adicional (8) . Em 1970, HUPF e BEAVER (83) produziram 67 Ga pela reação 68 Zn (p, 2n) 67 Ga, a partir de alvos de zinco na forma de tubo e na forma eletrodepositada em placas de prata/cobre. Após a irradiação, os alvos foram dissolvidos em HCl 5 mol L -1 .…”

Section: Métodos Utilizando a Extração Por Solventesunclassified

Desenvolvimento de método para separação química de Gálio-67 pela técnica de difusão térmica

Martins¹

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A Deus, primeiramente, acima de tudo, sobre todas as coisas. "TUDO É UM EM DEUS" (Mestre Masaharu Taniguchi) OFEREÇO Ao Igor, meu filho, meu amor, minha vida. Agradeço a Deus todos os dias pela sua existência. "Um anjo do céu, que veio pra mim. É o mais bonito, a jóia perfeita". (Anjo do Céu, Música de Natiruts). Aos meus pais, Cândido e Margarida, pela vida, amor, dedicação e sacrifícios. "Eu tenho tanto pra lhe falar, mas com palavras não sei dizer, como é grande o meu amor por vocês".

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Cyclotron production of carrier-free gallium-67

Cited by 40 publications

References 3 publications

Clinical Characteristics, Antimicrobial Resistance, and Outcomes of Patients with Invasive Pneumococcal Disease in Ningxia Hui Autonomous Region, China, 2013–2021

Clinical Characteristics, Antimicrobial Resistance, and Outcomes of Patients with Invasive Pneumococcal Disease in Ningxia Hui Autonomous Region, China, 2013–2021

Technetium and Gallium Derived Radiopharmaceuticals: Comparing and Contrasting the Chemistry of Two Important Radiometals for the Molecular Imaging Era

Desenvolvimento de método para separação química de Gálio-67 pela técnica de difusão térmica

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