Cyclotron production of high purity 44m,44 Sc with deuterons from 44 CaCO 3 targets

Alliot, Cyrille; Kerdjoudj, R.; Michel, Nathalie; Haddad, Férid; Huclier‐Markai, Sandrine

doi:10.1016/j.nucmedbio.2015.03.002

Cited by 68 publications

(72 citation statements)

References 37 publications

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“…As with our data, they reported higher adsorption of Sc from nitric acid solutions than from hydrochloric acid solutions, however neither author reported a decrease in Sc adsorption from 0.1 M to 1 M HCl. Furthermore, the absorption of Sc reported in our study is higher than reported by both Alliot [16] and Dirks [15]. The reason for the difference in magnitude of Sc adsorption may be due to differences in the experimental methods used.…”

Section: Sc Adsorptioncontrasting

confidence: 71%

“…While adsorption studies of Sc on DGA have been performed previously [15,16], we conducted k 0 measurements of Sc on DGA after the behavior of Sc on a DGA column did not behave as expected (as described in the column separation studies described below).…”

Section: Sc Adsorptionmentioning

confidence: 99%

“…Alliot [16] and Dirks [15] have both reported adsorption studies of Sc for DGA resin. As with our data, they reported higher adsorption of Sc from nitric acid solutions than from hydrochloric acid solutions, however neither author reported a decrease in Sc adsorption from 0.1 M to 1 M HCl.…”

Section: Sc Adsorptionmentioning

confidence: 99%

See 2 more Smart Citations

A new method for separating first row transition metals and actinides from synthetic melt glass

Roman

Bond

2016

J Radioanal Nucl Chem

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A new method was developed for separating Co, Fe, and Sc from complex debris matrices using the extraction chromatography resin DGA. The activation products Co-58, Mn-54, and Sc-46 were used to characterize the separation of the synthetic melt glass solutions. In the separation scheme that was developed, Au, Co, Cu, Fe, Sc, and Ti were separated from the rest of the sample constituents. In this paper, the synthetic melt glass separation method, efficiency, recoveries, and the length of procedure will be discussed. Batch contact adsorption studies for Na and Sc for DGA resin are discussed as well.

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Section: Sc Adsorptioncontrasting

confidence: 71%

Section: Sc Adsorptionmentioning

confidence: 99%

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A new method for separating first row transition metals and actinides from synthetic melt glass

Roman

Bond

2016

J Radioanal Nucl Chem

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“…43 Sc can be produced via proton irradiation of 43 Ca or 46 Ti, as well as a-irradiation of 40 Ca or deuteron irradiation of 44 Ca (5-7). 44g,m Sc can be produced via proton irradiation of 44 Ca, 47 Ti, or 45 Sc or deuteron irradiation of 44 Ca (2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Enriched targets are preferred to avoid production of contaminants such as 46,48 Sc (18).…”

mentioning

confidence: 99%

Production and Use of the First-Row Transition Metal PET Radionuclides^43,44Sc,⁵²Mn, and⁴⁵Ti

Chaple

Lapi

2018

J Nucl Med

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With the increasing focus on a more personalized approach to medicine using imaging techniques to select patients for targeted treatment or theranostic strategies, interest in the development of new radionuclides is expanding. Through the development of production and radiochemistry techniques, several new radiometals are being added to the toolbox of the nuclear imaging community. 43,44g,m Sc, 52g Mn, and 45 Ti are all emerging transition metal radionuclides and will be discussed in this short review. Each of these nuclides has unique imaging characteristics and shows promise for the development of new molecular imaging agents.

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“…Generator produced 44 Sc is eluted from 44 Ti (halflife = 59 years) using an ammonium acetate solution. 169,170 This variety of production methods makes scandium a versatile radiometal that could be widely used in the future, with the source being selected according to the user's requirements. 169,170 This variety of production methods makes scandium a versatile radiometal that could be widely used in the future, with the source being selected according to the user's requirements.…”

Section: Scandium-44mentioning

confidence: 99%

Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc

2016

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A key part of the development of metal based Positron Emission Tomography probes is the chelation of the radiometal. In this review the recent developments in the chelation of four positron emitting radiometals, Ga,Cu, Zr andSc, are explored. The factors that effect the chelation of each radio metal and the ideal ligand system will be discussed with regards to high in vivo stability, complexation conditions, conjugation to targeting motifs and complexation kinetics. A series of cyclic, cross-bridged and acyclic ligands will be discussed, such as CP256 which forms stable complexes with Ga under mild conditions and PCB-TE2A which has been shown to form a highly stable complex withCu. Zr andSc have seen significant development in recent years with a number of chelates being applied to each metal - eight coordinate di-macrocyclic terephthalamide ligands were found to rapidly produce more stable complexes with Zr than the widely used DFO.

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Cyclotron production of high purity 44m,44 Sc with deuterons from 44 CaCO 3 targets

Cited by 68 publications

References 37 publications

A new method for separating first row transition metals and actinides from synthetic melt glass

A new method for separating first row transition metals and actinides from synthetic melt glass

Production and Use of the First-Row Transition Metal PET Radionuclides^43,44Sc,⁵²Mn, and⁴⁵Ti

Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc

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Cyclotron production of high purity 44m,44 Sc with deuterons from 44 CaCO 3 targets

Cited by 68 publications

References 37 publications

A new method for separating first row transition metals and actinides from synthetic melt glass

A new method for separating first row transition metals and actinides from synthetic melt glass

Production and Use of the First-Row Transition Metal PET Radionuclides43,44Sc,52Mn, and45Ti

Current advances in ligand design for inorganic positron emission tomography tracers 68Ga, 64Cu, 89Zr and 44Sc

Contact Info

Product

Resources

About

Production and Use of the First-Row Transition Metal PET Radionuclides^43,44Sc,⁵²Mn, and⁴⁵Ti

Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc