Cyclotron production of no carrier added 186gRe radionuclide for theranostic applications

Khandaker, Mayeen Uddin; Nagatsu, Kotaro; Minegishi, Katsuyuki; Zhang, Ming‐Rong; Jalilian, Amir Reza; Bradley, D.A.

doi:10.1016/j.apradiso.2020.109428

Cited by 4 publications

(1 citation statement)

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“…Re-186 can be produced using nuclear reactors or particle accelerators [5]. The (n, γ) reaction of Re-185 in the nuclear reactor is 112 (barn) compared to ~0.6 (barn) for the (d, 2n) reaction of W-186 at ~15 (MeV) in the particle accelerator [6], which means that the production process in the nuclear reactor can produce large amounts of Re-186. On the other hand, the nuclear reactor process produces Re-186 with carriers, resulting in low specific activity [7].…”

Section: Introductionmentioning

confidence: 99%

Feasibility Study on Production of High-Purity Rhenium-185 by Nuclear Transmutation of Natural Tantalum

Tanoue,

Yokoyama,

Ozawa

2023

JNE

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Rhenium-186 (Re-186) has attracted attention as a medical isotope. The feasibility of producing Re-185, the raw material for Re-186, using a fast reactor was evaluated using a continuous energy Monte Carlo code. The irradiation of natural tantalum (Ta) in the fast reactor can produce Re-185 with an isotopic purity of 99%. A two-step irradiation process with different moderators was found to improve the production rate of Re-185. Specifically, this can be achieved by using zirconium hydride (ZrH1.7) as a moderator in the first transmutation process from natural Ta to tungsten (W), and then zirconium deuteride (ZrD1.7) as a moderator in the second transmutation process from W to Re-185. Due to the two-step irradiation, the production rate of Re-185 from Ta can be increased up to a maximum of 470 times compared with irradiation without a moderator, and 2.3 g of Re-185 can be obtained from 1571 g of Ta in 1 year of irradiation. The proposed isotope production method is a new method that is different from the conventional electromagnetic enrichment process.

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Section: Introductionmentioning

confidence: 99%