1994
DOI: 10.1016/0959-8049(94)90528-2
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CYFRA 21-1, a sensitive and specific new tumour marker for squamous cell lung cancer. Report of the first European multicentre evaluation

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Cited by 118 publications
(58 citation statements)
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“…Early studies reported very low sensitivity of various markers like CEA (carcinoembryonic antigen) (Silverman et al, 1976;Walther et al, 1990), Lipid associated sialic acid (Katopodis et al, 1982;Ropka et al, 1991) and SCC-marker (TA-4) (Calsen et al, 1990;Daver et al, 1990;Fichbach et al, 1990;Walther et al, 1990;Yoshimura et al, 1990;Ropka et al, 1991) in head and neck cancer patients. Cyfra 21-1 was reported as a new marker for non-small cell carcinoma of the lung (Pujol et al, 1993;Stieber et al, 1993;Rastel et al, 1994). For SCC of the lung, the sensitivity was 60% and specificity was 95%.…”
mentioning
confidence: 99%
“…Early studies reported very low sensitivity of various markers like CEA (carcinoembryonic antigen) (Silverman et al, 1976;Walther et al, 1990), Lipid associated sialic acid (Katopodis et al, 1982;Ropka et al, 1991) and SCC-marker (TA-4) (Calsen et al, 1990;Daver et al, 1990;Fichbach et al, 1990;Walther et al, 1990;Yoshimura et al, 1990;Ropka et al, 1991) in head and neck cancer patients. Cyfra 21-1 was reported as a new marker for non-small cell carcinoma of the lung (Pujol et al, 1993;Stieber et al, 1993;Rastel et al, 1994). For SCC of the lung, the sensitivity was 60% and specificity was 95%.…”
mentioning
confidence: 99%
“…These cut-off values correspond to a 95% specificity for all markers determined in 546 patients with non-malignant lung diseases (Rastel et al, 1993).…”
mentioning
confidence: 99%
“…In comparative studies cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 (CYFRA 21.1) has proved to be the marker of choice in non-small cell lung cancer [3][4][5][6][7][8][9][10][11] and is also of independent prognostic value [3,12,13].…”
mentioning
confidence: 99%