CYFRA 21–1 as a tumor marker for squamous cell carcinoma of the esophagus

Nakamura, Toshio; H, Ide; Eguchi, Reiki; Hayashi, Kenji; Takasaki, Kazuki; Watanabe, S

doi:10.1093/dote/11.1.35

Cited by 51 publications

(45 citation statements)

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“…Data from other researchers is similar ranging be- 17 noted that the diagnostic sensitivity of CYFRA 21-1 (33.9%) was superior to SCC antigen (28.6%) and CEA (12.5%). In the current study, the sensitivity of CYFRA 21-1 (43.9%) was found to be superior than that of SCC antigen (26.8%) and CEA (17.0%).…”

Section: Discussionsupporting

confidence: 77%

CYFRA 21-1 determination in patients with esophageal squamous cell carcinoma

Kawaguchi

Ohno

Miyazaki

et al. 2000

Cancer

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Section: Discussionsupporting

confidence: 77%

CYFRA 21-1 determination in patients with esophageal squamous cell carcinoma

Kawaguchi

Ohno

Miyazaki

et al. 2000

Cancer

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“…On the other hand, the acidic form is the dominant form of the serum SCC and it is thought to be secreted by malignant cells. However, the sensitivity of the serum SCC antigen is 28.6-37% (Mealy et al, 1996;Nakamura et al, 1998;Quillien et al, 1998) in oesophageal cancer. Therefore the acidic form may not always be produced in oesophageal cancer cells.…”

Section: Discussionmentioning

confidence: 98%

Detection of lymph node metastasis of oesophageal cancer by RT-nested PCR for SCC antigen gene mRNA

et al. 2000

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Summary With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC) antigen gene as a marker with RT-nested PCR to detect occult lymph node metastases of oesophageal cancer. The SCC antigen has been widely used as a serum tumour marker and was reported as a target gene to detect tumour cells in peripheral blood in cervical cancer. In this study, 620 lymph nodes from 14 oesophageal cancer patients were analysed. The results of RT-nested PCR were compared with that of pathological and immunohistochemical examinations. In the test of sensitivity, the RT-nested PCR detected 10 1 of SCC antigen producing cells in 10 7 peripheral blood mononucleocytes and was not found in 43 control lymph nodes. The pathological examination, immunohistochemical examination and the RT-nested PCR detected 36, 45 and 65 nodes respectively. The RT-nested PCR detected statistically more lymph nodes than the pathological or immunohistochemical examination. The sensitivity and specificity seem higher in squamous cell carcinoma cases. The SCC antigen gene is one of the more useful markers for RT-nested PCR to detect occult lymph node metastases of oesophageal cancer.

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“…The specificity, sensitivity and accuracy of CYFRA21-1 were 100%, 47.9% and 66.7%, respectively. Nakamura et al (1998) reported that there is a correlation between CYFRA21-1 levels and clinical responses in patients who received chemotherapy or CRT. CYFRA 21-1 correlates better with the pathologic TNM stage.…”

Section: Discussionmentioning

confidence: 99%