Cylindrin from Imperata cylindrica inhibits M2 macrophage formation and attenuates renal fibrosis by downregulating the LXR-α/PI3K/AKT pathway

Macrophage plasticity: signaling pathways, tissue repair, and regeneration

“… 201 , 202 LXR agonists have demonstrated anti‐inflammatory and immunomodulatory effects in various disease models, including atherosclerosis, Alzheimer's, and autoimmune disorders. 203 , 204 These effects are mediated, in part, by the ability of LXRs to inhibit NF‐κB signaling and promote the resolution of inflammation. 205 As such, targeting LXR signaling has emerged as a potential therapeutic strategy for modulating macrophage polarization and function in inflammatory diseases.…”

MAPKAP1 orchestrates macrophage polarization and lipid metabolism in fatty liver-enhanced colorectal cancer

“…Several studies have demonstrated an increase in the proportion of M2 macrophages in the tumor microenvironment of CRC, which is strongly correlated with the malignant progression and unfavorable prognosis of CRC [21] . Consequently, regulating macrophage polarization, specifically the inhibition of M2 macrophage formation and function, has emerged as a promising therapeutic approach [22] .…”

Optimization of ultrasound-assisted extraction of Imperata cylindrica polysaccharides and evaluation of its anti-oxidant and amelioration of uric acid stimulated cell apoptosis

“… [11] , [12] . It exhibits various effects, including anti-oxidant [13] , anti-inflammatory [14] , anti-fibrotic [15] , and cardiovascular protection [16] . In our previous study, we obtained crude Imperata cylindrica polysaccharide (ICPs) through traditional hot water extraction, and further obtained ICPC-b through alcohol precipitation and DEAE-52 purification [17] .…”