Cylindrospermopsin: cyanobacterial secondary metabolite. Biological aspects and potential risk for human health and life

Adamski, Michał; Chrapusta, Ewelina; Bober, Beata; Kamiński, Ariel; Białçzyk, Jan

doi:10.2478/s13545-014-0148-5

Cited by 14 publications

(5 citation statements)

References 59 publications

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“…Aquatic bioaccumulation and biomagnification potential of various cyanotoxins including CYNs, anatoxins, and MCs have been reported; such observations are associated with ecological impacts (Al-Sammak et al, 2014;Ferrão-Filho and Kozlowsky-Suzuki 2011;White et al, 2005). For humans, the ingestion of CYN through contaminated drinking water or edible fish and shellfish can lead to several detrimental health effects (Abeysiriwardena et al, 2018;Adamski et al, 2014;Kalaitzis et al, 2010). CYN was originally characterized as hepatotoxic in the early 1990s (Ohtani et al, 1992), but not until recently has also been identified as potentially genotoxic, dermatotoxic, developmentally toxic, and carcinogenic (Armah et al, 2013), mostly based on findings from mammals.…”

Section: Introductionmentioning

confidence: 99%

Global scanning of cylindrospermopsin: Critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards

Scarlett

Kim

Lovin

et al. 2020

Science of The Total Environment

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Cylindrospermopsin (CYN), a cyanotoxin produced by harmful algal blooms, has been reported worldwide; however, there remains limited understanding of its potential risks to surface water quality. In the present study, we reviewed available literature regarding the global occurrence, bioaccumulation, and toxicity of CYN in aquatic systems with a particular focus on fresh water. We subsequently developed environmental exposure distributions (EEDs) for CYN in surface waters and performed probabilistic environmental hazard assessments (PEHAs) using guideline values (GVs). PEHAs were performed by geographic region, type of aquatic system, and matrix. CYN was prevalent in North America, Europe, and Asia/Pacific, with lakes being the most common system. Many global whole water EEDs exceeded guideline values (GV) previously developed for drinking water (e.g., 0.5 μg L −1 ) and recreational water (e.g., 1 μg L −1 ). GV exceedances were higher in the Asia/Pacific region, and in rivers and reservoirs. Rivers in Asia/ Pacific region exceeded the lowest drinking water GV 73.2% of the time. However, the lack of standardized protocols used for analyses was alarming, which warrants improvement in future studies. In addition, bioaccumulation of CYN has been reported in mollusks, crustaceans, and fish, but such exposure information remains limited. Though several publications have reported aquatic toxicity of CYN, there is a lack of chronic aquatic toxicity data especially for higher trophic level organisms. Most aquatic toxicity studies have not employed standardized experimental designs, *

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Section: Introductionmentioning

confidence: 99%

Global scanning of cylindrospermopsin: Critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards

Scarlett

Kim

Lovin

et al. 2020

Science of The Total Environment

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“…Recently, one of the most studied cyanotoxins are cytotoxic alkaloid cylindrospemopsin (CYN) (Figure 1A), hepatotoxic oligopeptide microcystine-LR (MC-LR) (Figure 1B), and neurotoxic alkaloid anatoxin-a (ATX-a) (Figure 1C). e impact of cyanotoxins on living cells is broad and affects many processes in various organs (Adamski et al, 2014;Campos et al, 2021;Corbel et al, 2014;de La Cruz et al, 2013;Jaiswal et al, 2008;Malta et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Among the toxins produced by cyanobacteria, CYN has the broadest range of action and impairs several metabolic pathways in both animal and plant cells (Adamski et al, 2014;de La Cruz et al, 2013;Moreira et al, 2013). For the first time, it was isolated from Raphidiopsis raciborskii (former Cylindrospermopsis raciborskii) aer an incident of hepatoenteritis in humans on Palm Island in Queensland (Australia) (Hawkins et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

The first report of the production of anatoxin-a by Bolivian terrestrial cyanobacteria

Adamski,

Flakus,

Kaminski

et al. 2024

Acta Soc Bot Pol

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Cyanobacterial harmful algal blooms (CyanoHABs) are observed in many regions worldwide with increasing frequency. The massive development of cyanobacteria is a severe problem for the water environment due to negative changes in water parameters, the introduction of toxic metabolites (cyanotoxins) into the water, and the resulting disruption of ecological relations in the ecosystem. Knowledge regarding CyanoHABs in aquatic reservoirs is increasing. However, information about cyanobacteria development in other, untypical habitats like deserts, open soils, or polar regions is still insufficient. Similarly, data regarding the distribution of cyanotoxins are extensive for some regions (for example, in Europe or North America), whereas, in other localities, such as those in South America, the data are scarce. In this paper, we investigated if phototrophic microbial communities collected from open soil (La Paz department, Sud Yungas province, Bolivia) contained cyanobacteria described as cyanotoxin producers. We performed qualitative and quantitative analysis of typical cyanotoxins found in aquatic reservoirs – anatoxin-a (ATX-a), cylindrospermopsin (CYN), and microcystin-LR (MC-LR). The obtained results showed a relatively high biodiversity of the studied microbial phototrophic community, which consists of several cyanobacterial and algal genera. Analyses of cyanotoxins showed that CYN and MC-LR were not present in the studied samples. However, despite the lack of cyanobacteria described as ATX-a producers, high-performance liquid chromatography (HPLC) chromatograms were revealed, and mass spectrometry (MS) spectra confirmed the presence of the toxin in the studied material. The results presented in this paper are, to the best of our knowledge, the first confirmation of the presence of ATX-a in open soil habitats, as well as the first record of cyanotoxin occurrence in Bolivia. The identification of anatoxin-producing cyanobacteria in open soil environments presents a novel finding that necessitates further work to elucidate their prevalence, abundance, and associated potential hazards, as well as the taxonomic classification of the specific cyanobacterial species able for anatoxin synthesis within these soil habitats. Future studies should focus on the distribution of cyanotoxins in cyanobacterial communities in untypical habitats and in localities for which, to date, the information on cyanotoxin occurrence is not currently available.

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“…Certain secondary metabolites synthesized by cyanobacteria, known as cyanotoxins, are some of the most dangerous compounds produced in nature. Based on their effect on vertebrates, these compounds can be divided into four groups: hepatotoxins, neurotoxins, cytotoxins and dermatotoxins [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Effect of Microcystin-LR, Nodularin, Anatoxin-a, β-N-Methylamino-L-Alanine and Domoic Acid on Antioxidant Properties of Glutathione

Adamski

Kamiński

2022

Life

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Cyanobacteria produce a range of toxic secondary metabolites that affect many processes in human, animal and also plant cells. In recent years, some efforts have concentrated on deepening the understanding of their effect on living cells in the context of the disruption of antioxidant systems. Many results suggest that cyanotoxins interfere with glutathione (GSH) metabolism, which often leads to oxidative stress and, in many cases, cell death. Knowledge about the influence of cyanotoxins on enzymes involved in GSH synthesis or during its antioxidant action is relatively broad. However, to date, there is no information about the antioxidant properties of GSH after its direct interaction with cyanotoxins. In this paper, we investigated the effect of four cyanotoxins belonging to the groups of hepatotoxins (microcystin-LR and nodularin) or neurotoxins (anatoxin-a and β-N-methylamino-L-alanine) on the in vitro antioxidant properties of GSH. Moreover, the same study was performed for domoic acid (DA) produced by some diatoms. The obtained results showed that none of the studied compounds had an effect on GSH antioxidant potential. The results presented in this paper are, to the best of our knowledge, the first description of the kinetics of scavenging radicals by GSH reactions under the influence of these cyanotoxins and DA. This work provides new and valuable data that broadens the knowledge of the impact of cyanotoxins and DA on GSH metabolism and complements currently available information. Future studies should focus on the effects of the studied compounds on antioxidant systems in vivo.

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Cylindrospermopsin: cyanobacterial secondary metabolite. Biological aspects and potential risk for human health and life

Cited by 14 publications

References 59 publications

Global scanning of cylindrospermopsin: Critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards

Global scanning of cylindrospermopsin: Critical review and analysis of aquatic occurrence, bioaccumulation, toxicity and health hazards

The first report of the production of anatoxin-a by Bolivian terrestrial cyanobacteria

Effect of Microcystin-LR, Nodularin, Anatoxin-a, β-N-Methylamino-L-Alanine and Domoic Acid on Antioxidant Properties of Glutathione

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