Cynaropicrin- and chlorogenic acid-rich extracts easily prepared from Cynara cardunculus var. scolymus: Antioxidant and antigenotoxic properties

Gonçalves, Ana; Sampaio, Cátia I.; Ševčovičová, Andrea; Dias, Alice M.; Oliveira, Rui

doi:10.1016/j.bcab.2023.102808

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…The most important bioactives found in artichoke are polyphenolic compounds (mainly flavonoids and phenolic acids) and sesquiterpenes such as cynaropicrin. It has been reported that the leaves have a higher concentration of sesquiterpenes and phenolic compounds [21]. In recent years, artichoke extracts have gained interest in topical applications, including cosmetics.…”

Section: Introductionmentioning

confidence: 99%

Artichoke Leaf Extract Effectiveness on the Skin Aging Exposome: Efficacy and Safety Results of a Split-Face Study

Roveda,

Cestone,

De Gennaro

et al. 2024

Cosmetics

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The skin is a barrier organ subjected to lifelong exposure to internal and external factors influencing both its biological response and appearance. A randomized split-face study was carried out on 22 adult female outdoor workers using an artichoke leaf extract (CynageTM). The product’s efficacy was measured before and after 28 days of use. The following skin parameters were measured: wrinkle depth, skin roughness, and radiance, to assess the product’s effect on the skin appearance; Ferric Reducing Antioxidant Power (FRAP), to assess the total antioxidant capacity; and tumor necrosis factor-alpha (TNF-α) levels, to assess the anti-inflammatory efficacy. These parameters were also integrated by the evaluation of the subjective perception of product efficacy. After 28 days of product use, the skin’s appearance improved as follows: wrinkle depth and skin roughness decreased by 5.2% and 7.0%, respectively, while the skin radiance increased by 19.0%. The total antioxidant capacity of the skin increased by 20.2%. The skin’s TNF-α levels decreased by 8.2%. The product efficacy was also perceived by the subjects participating in the study. The product was well tolerated. Our findings demonstrate the active role of the ingredient in decreasing the skin damage induced by the exposome.

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Section: Introductionmentioning

confidence: 99%

Artichoke Leaf Extract Effectiveness on the Skin Aging Exposome: Efficacy and Safety Results of a Split-Face Study

Roveda,

Cestone,

De Gennaro

et al. 2024

Cosmetics

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Exploring Cynara cardunculus L. by-products potential: Antioxidant and antimicrobial properties

Barbosa,

Duarte,

Andrade

et al. 2024

Industrial Crops and Products

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Agroprospecting of Biowastes: Globe Artichoke (Cynara scolymus L. Cultivar Tema, Asteraceae) as Potential Source of Bioactive Compounds

Alves-Silva,

Zuzarte,

Salgueiro

et al. 2024

Molecules

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Artichokes (Cynara scolymus L.) are valuable foods, thanks to their health benefits, but they generate significant waste during their production, harvesting, and processing, which poses sustainability issues. This study applied an agroprospecting approach to convert Tema artichoke biowaste (TB) into valuable resources, starting from a global perspective of the production chain to the targeted applications based on chemical and biological analysis. The major TB was identified in the outer bracts of the immature flower heads, which were collected throughout the harvesting season, extracted, and analyzed. The most abundant compounds were phenolic acids including chlorogenic acid and caffeoylquinic derivatives. Among flavonoids, cynaroside was the most abundant compound. Multivariate analysis distinguished batches by collection period, explaining 77.7% of the variance, with most compounds increasing in concentration later in the harvest season. Subsequently, TB extracts were analyzed for their potential in wound healing and anti-aging properties. Fibroblasts were used to assess the effect of selected extracts on cell migration through a scratch wound assay and on cellular senescence induced by etoposide. The results show a significant decrease in senescence-associated β-galactosidase activity, γH2AX nuclear accumulation, and both p53 and p21 protein levels. Overall, this study ascribes relevant anti-skin aging effects to TB, thus increasing its industrial value in cosmeceutical and nutraceutical applications.

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Cynaropicrin- and chlorogenic acid-rich extracts easily prepared from Cynara cardunculus var. scolymus: Antioxidant and antigenotoxic properties

Cited by 3 publications

References 59 publications

Artichoke Leaf Extract Effectiveness on the Skin Aging Exposome: Efficacy and Safety Results of a Split-Face Study

Artichoke Leaf Extract Effectiveness on the Skin Aging Exposome: Efficacy and Safety Results of a Split-Face Study

Exploring Cynara cardunculus L. by-products potential: Antioxidant and antimicrobial properties

Agroprospecting of Biowastes: Globe Artichoke (Cynara scolymus L. Cultivar Tema, Asteraceae) as Potential Source of Bioactive Compounds

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