1998
DOI: 10.1006/abbi.1998.0901
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CYP12A1, a Mitochondrial Cytochrome P450 from the House Fly

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Cited by 121 publications
(76 citation statements)
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“…Cyp12d1 is of special interest because it encodes a mitochondrial P450, whereas the other genes encode microsomal P450s. The related CYP12A1 of the housefl y is also inducible by phenobarbital, and metabolizes several xenobiotics (Guzov et al, 1998). The CYP12-like P450s of insects are thus a special type of inducible, environmental response genes, unlike the steroid-metabolizing mitochondrial P450s of vertebrates and insects.…”
Section: Discussionmentioning
confidence: 99%
“…Cyp12d1 is of special interest because it encodes a mitochondrial P450, whereas the other genes encode microsomal P450s. The related CYP12A1 of the housefl y is also inducible by phenobarbital, and metabolizes several xenobiotics (Guzov et al, 1998). The CYP12-like P450s of insects are thus a special type of inducible, environmental response genes, unlike the steroid-metabolizing mitochondrial P450s of vertebrates and insects.…”
Section: Discussionmentioning
confidence: 99%
“…This initial correlation was confirmed by genomic PCR and sequencing when it was found that base alterations leading to premature stop codons created null alleles lacking the critical catalytic heme-binding site. The insect genes most closely related to sad and dib are CYP12A1, a mitochondrial P450 from the house fly (22), and CYP12B1 from Drosophila acanthoptera (23). As with these enzymes, Sad contains a conserved N-terminal amphipathic region required for mito- chondrial import (24).…”
Section: Discussionmentioning
confidence: 99%
“…For example, CYP6B1v1 and CYP6B3v1 from the black swallowtail butterfly, Papilio polyxenes, can metabolize the furanocoumarins it is exposed to in its diet (32,33). Numerous individual P450s have also been implicated in insecticide resistance in different insect populations (34)(35)(36)(37)(38).…”
mentioning
confidence: 99%