CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer

Boccia, Stefania; Cadoni, Gabriella; Sayed‐Tabatabaei, Fakhredin A.; Volante, M.; Arzani, Dario; Lauretis, Angelo De; Cattel, Caterina; Almadori, Giovanni; Duijn, Cornelia M. van; Paludetti, Gaetano; Ricciardi, Walter

doi:10.1007/s00432-007-0254-5

Cited by 84 publications

(85 citation statements)

References 34 publications

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“…A total of 45 abstracts were retrieved through PubMed and Medline, and 2 additional articles were found through the ISI Web of Knowledge. After reviewing all 47 articles carefully, 16 eligible articles including 2,965 cases with HNC and 3,919 controls were identified and included in the final meta-analysis (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34). The main characteristics of all 16 studies are described in Table I.…”

Section: Resultsmentioning

confidence: 99%

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Association of NAT2 phenotype with risk of head and neck carcinoma: A meta-analysis

Zheng

Teng

et al. 2011

Oncology Letters

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Abstract. N-acetyltransferase 2 (NAT2) is a key enzyme involved in the metabolism of xenobiotics and plays a significant role in the detoxification of numerous potential carcinogens. According to its acetylation status, NAT2 acetylator may be classified into two phenotypes, rapid and slow. Numerous studies have demonstrated that the polymorphisms of NAT2 were correlated with individual susceptibility to several malignant neoplasms, including head and neck carcinomas (HNC). However, the associations between the acetylator phenotypes and HNC risk in each study were not entirely consistent. To assess these associations more comprehensively, we performed a meta-analysis. In this meta-analysis, 16 eligible studies including 2,965 cases with HNC and 3,919 controls were identified by searching the databases of PubMed, Medline and the ISI Web of Knowledge. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were used to evaluate the association. No significant associations between the rapid acetylator phenotype in NAT2 and HNC risk were found either in the overall analysis (OR=0.98; 95% CI 0.83, 1.15; I 2 =57%; P heterogeneity =0.003) or in the subgroup analysis by ethnicity (for the Caucasian population, OR=1.03, 95% CI 0.85, 1.24, I 2 = 63%, P heterogeneity = 0.002; for other mixed populations, OR=0.78, 95% CI=0.61, 1.00, I 2 = 0%, P heterogeneity =0.47). In conclusion, this meta-analysis suggested that there is no association between the NAT2 phenotype and the risk of HNC. IntroductionHead and neck carcinoma (HNC), arising from the sites of the oral cavity, oropharynx, hypopharynx and larynx, is the sixth most common type of cancer worldwide (1). It is characterized by a moderately low survival rate, a high recurrence rate, and a high rate of second primary malignancy (2). In 2009, approximately 49,260 new cases (35,530 males and 13,730 females) of HNC were diagnosed in the USA, and 11,480 deaths occurred (8,300 males and 3,180 females) (1). Present evidence has proven that numerous factors contribute to the risk of squamous cell carcinoma of the head and neck, including tobacco use, alcohol consumption (3), viral infection (4) and genetic polymorphisms (5). In particular, tobacco smoking and alcohol consumption account for approximately 80% of HNC cases (6,7). However, it is worth noting that only a fraction of smokers and alcohol consumers develop HNC. This phenomenon suggests that host factors, including genetic variation, contribute to the inter-individual variation in the susceptibility to HNC.Numerous procarcinogens are known to exist in tobacco, including polycyclic aromatic hydrocarbons (PAHs), aromatic and heterocyclic amines; nitroso-compounds in smoking tobacco; and nitrosamines, aromatic and heterocyclic amines in smokeless tobacco. Most of these carcinogens generally undergo bioactivation and inactivation by phase Ⅰ and Ⅱ enzymes, respectively. The phase Ⅱ enzymes, including Glutathione S-transferases (GSTs) and N-acetyltransferase (NAT), contribute to the detoxification metabolism. Human NAT compr...

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Section: Resultsmentioning

confidence: 99%

“…The year of publication of the included studies ranged from 1998 to 2010. There were 11 studies of Caucasians (19,(21)(22)(23)(25)(26)(27)(28)30,31,34), 3 of Asians (24,32,33), 1 of Turkish (20) and 1 of a mixed population (including Caucasian and other mixed populations) (29). All cases of HNC were pathologically confirmed.…”

Section: Resultsmentioning

confidence: 99%

Association of NAT2 phenotype with risk of head and neck carcinoma: A meta-analysis

Zheng

Teng

et al. 2011

Oncology Letters

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“…Many studies have been performed to detect the association between genetic polymorphisms of GSTs and cancer risk of various organs [6,[10][11][12]. It is reported that, in humans, there are eight distinct gene fam-ilies encoding the GSTs.…”

Section: Introductionmentioning

confidence: 99%

Is there any association of glutathione S-transferase T1 (GSTT1) and glutathione S-transferase M1 (GSTM1) gene polymorphism with gastric cancers?

Haholu¹,

Berber²,

Karagöz³

et al. 2013

pjp

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The glutathione S-transferases (GST) are enzymes catalyzing reactions including carcinogens. GSTT1 and GSTM1 genes are polymorphic in humans. The relations between polymorphism of some GST genes and cancer have been reported. In this study, we aimed to investigate the distribution of GSTT1 and GSTM1 polymorphisms in a group of gastric cancer patients. The study group consisted of 50 patients (21 females, 29 males) with gastric adenocarcinoma from the archives of the pathology department of a training hospital. Fifty-seven healthy control subjects were included in the study as a control group. DNA was extracted from peripheral venous blood of control subjects and from the paraffin blocks of cases. Genotyping of GSTT1 and GSTM1 genes was performed with duplex polymerase chain reaction. No differences in the frequencies of GSTM1 or GSTT1 null genotypes were observed between patients and healthy subjects (GSTM1: 52% vs. 43.85%, OR = 1.27, 95% CI: 0.55-2.96; GSTT1: 38.46% vs. 28.07%, OR = 0.72, 95% CI: 0.25-1.96). Moreover, simultaneous carriage of both genotypes was almost identical in both groups. GSTM1 or GSTT1 null genotypes were not different in diffuse or intestinal type gastric cancer. Our data suggest that the GSTM1 and GSTT1 polymorphisms are not associated with gastric cancer in a small group of the Turkish population.

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“…the cancer process is usually a multistep phenomenon, during which successive somatic cell mutations occur. Genes involved in cell cycle control, genetic repair systems, or encoded enzymes for biotransformation of environmental carcinogens have important roles in this process (5,10).…”

Section: Introductionmentioning

confidence: 99%

“…Though constitutive extrahepatic CYP1A1 expression is generally extremely low, CYP1A1 can be found in tissues such as prostate, mammary gland, intestine, thymus, colon, adrenal, ovary, uterus, lung, and testis. Various CYP1A1 gene polymorphisms have been found to be differentially associated with increased risk of several cancers (including cancer of the lung, breast, and colon) in different specific ethnic groups (1,4,5,14,20). enzymes, glutathione S-transferase (GSts), affect and activate metabolites of carcinogens in order to be subjected to metabolic conjugation and other kinds of detoxifications.…”

Section: Introductionmentioning

confidence: 99%

Study on Polymorphism and Activities of GSTM1 and CYP1A1 Genes in Connection with Various Cancer Types in Turkey Population

Vural¹,

Turaçlar²,

Elagöz³

2010

Biotechnology & Biotechnological Equipment

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CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer

Cited by 84 publications

References 34 publications

Association of NAT2 phenotype with risk of head and neck carcinoma: A meta-analysis

Association of NAT2 phenotype with risk of head and neck carcinoma: A meta-analysis

Is there any association of glutathione S-transferase T1 (GSTT1) and glutathione S-transferase M1 (GSTM1) gene polymorphism with gastric cancers?

Study on Polymorphism and Activities of GSTM1 and CYP1A1 Genes in Connection with Various Cancer Types in Turkey Population

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