CYP1A1 Genetic Polymorphisms and Risk for Esophageal Cancer: a Case-control Study in Central China

Yun, Yu Xia; Wang, Yan Ping; Wang, Peng; Cui, Li Hong; Wang, Kai Juan; Zhang, Jian Ying; Dai, Li

doi:10.7314/apjcp.2013.14.11.6507

Cited by 15 publications

(11 citation statements)

References 30 publications

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“…Data from a meta-analysis study on lung cancer, drawing from 13 existing studies comprising of subjects from Japan, China, Korea and Thailand found that the prevalence of C allele is around 42.4% (Lee et al, 2008). More recently, a study on lung cancer in the Inner Mongolia region reported with a high level of the C allele (~50%) (Jiang et al, 2014) whereas a different study on esophageal cancer in Central China reported that the C/C genotype in China to be around ~37% (Yun et al, 2013). Both our data and the findings from these studies seem to be in concurrence whereby the prevalence of C alleles within Asian populations is generally around 35% to 50%.…”

Section: Discussionmentioning

confidence: 99%

“…A single nucleotide polymorphism (SNP) of CYP1A1 at position 3801 in the 3' untranslated region results in a change of a T to C base (Spurr et al, 1987). Consequently, this resulting MspI polymorphism has been extensively studied alongside numerous malignancies including cervical carcinoma, esophageal carcinoma, oral carcinoma, breast carcinoma, colorectal cancer and lung carcinoma (Sivaraman et al, 1994;Tanimoto et al, 1999;Kim et al, 2000;Goodman et al, 2001;Boyapati et al, 2005;Joseph et al, 2006;Agorastos et al, 2007;Juarez-Cedillo et al, 2007;Nishino et al, 2008;Gutman et al, 2009;Chen et al, 2011;von Keyserling et al, 2011;Sergentanis et al, 2012;Shukla et al, 2012;Zhuo et al, 2012a;Zhuo et al, 2012b;Ding et al, 2013;Islam et al, 2013;Liu et al, 2013;Saeed et al, 2013;Shukla et al, 2013;Xia et al, 2013;Yun et al, 2013;Jiang et al, 2014). The association between this CYP1A1 polymorphism with cervical carcinoma has been examined previously in various populations, with mixed results.…”

Section: Introductionmentioning

confidence: 99%

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CYP1A1 MspI Polymorphism and Cervical Carcinoma Risk in the Multi-Ethnic Population of Malaysia: a Case-Control Study

Tan¹,

Sidik²,

Husain³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: Tobacco smoking is considered a risk factor for cervical cancer development due to the presence of tobacco based carcinogenic metabolites in cervical cells of female smokers. In this study, we investigated the role of the T3801C (MspI) polymorphism of CYP1A1, a gene encoding an enzyme necessary for the initiation of tobacco based carcinogen metabolism, on cervical cancer risk. The T to C substitution may alter CYP1A1 activities, potentially elevating cervical cancer risk. Since results of gene-disease association studies vary according to the study population, the multi-ethnic population of Malaysia provides an excellent representative cohort for identifying and comparing the cervical cancer risk among the 3 major ethnics in Southeast Asia in relation to CYP1A1 MspI polymorphism. Materials and Methods: A total of 195 Thin Prep Pap smear samples from HPV negative and cancer free females were randomly selected as controls while 106 formalin fixed paraffin embedded samples from females with invasive cervical cancer were randomly selected for the cases group. The polymorphisms were identified using restriction fragment length polymorphism (RFLP) PCR. Results: We found no significant associations between CYP1A1 MspI polymorphism and cervical cancer in the general Malaysian female population. However, upon ethnic stratification, the variant C/C genotype was significantly associated with a 4.66-fold increase in cervical cancer risk in Malay females (95% CI= 1.21-17.9; p=0.03). No significant association was observed in the Chinese and Indian females. Additionally, there were no significant associations in the dominant model and allele frequency model analysis in both the general and ethnically stratified female population of Malaysia. Conclusions: Our findings suggest that the C/C genotype of CYP1A1 MspI polymorphism is associated with the development of cervical carcinoma in the Malay females of Malaysia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CYP1A1 MspI Polymorphism and Cervical Carcinoma Risk in the Multi-Ethnic Population of Malaysia: a Case-Control Study

Tan¹,

Sidik²,

Husain³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…The confirmed carcinogenic species reported in tobacco mainly include nitrosamines, aromatic amines and polyaromatic hydrocarbons (PAH) (Yun et al, 2013). Tobacco use and alcoholism have also been shown to possess synergistic effects increasing the relative risk over 100-times than that of induced by tobacco or alcohol use alone.…”

Section: Introductionmentioning

confidence: 99%

Genetic Susceptibility to Esophageal Cancer due to CYP1A1 Gene Variant rs4646903 in Tobacco Addicted Patients of Pashtun Ethnicity: a Case Control Study in Khyber Pakhtunkhwa Province of Pakistan

Zakiullah

Saeed²,

Ali³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…After extracting the DNAg, it was amplified by polymerase chain reaction and subsequent digestion with restriction enzymes (Lee et al 2006;Yun et al 2014).…”

Section: Genotypic Analysismentioning

confidence: 99%

Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Alvarado¹,

Muñoz²,

Bartra³

et al. 2021

PHAR

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The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type GSTM1 (+) and 47% with null GSTM1. The frequency in Iquiteño emigrants was 0.72 CYP1A1*2A and 25% GSTM1 (-); from Lima 0.67 CYP1A1*2A and 33% of GSTM1 (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05. The presence of the risk allele of the CYP1A1*2A polymorphism and the deletion in the GSTM1 gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.

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CYP1A1 Genetic Polymorphisms and Risk for Esophageal Cancer: a Case-control Study in Central China

Cited by 15 publications

References 30 publications

CYP1A1 MspI Polymorphism and Cervical Carcinoma Risk in the Multi-Ethnic Population of Malaysia: a Case-Control Study

CYP1A1 MspI Polymorphism and Cervical Carcinoma Risk in the Multi-Ethnic Population of Malaysia: a Case-Control Study

Genetic Susceptibility to Esophageal Cancer due to CYP1A1 Gene Variant rs4646903 in Tobacco Addicted Patients of Pashtun Ethnicity: a Case Control Study in Khyber Pakhtunkhwa Province of Pakistan

Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

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