CYP2C19*2 polymorphism in Polish peptic ulcer patients

Sałagacka-Kubiak, Aleksandra; Żebrowska-Nawrocka, Marta; Jeleń, Agnieszka; Mirowski, Marek; Balcerczak, Ewa

doi:10.1016/j.pharep.2018.12.011

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…Salagacka-Kubiak et al. 18 suggested there is some interaction between gender, CYP2C19*2 polymorphism, and pathogenesis of Helicobacter pylori infection development. However, the conclusions are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…16,17 Recently, emerging studies have revealed the important role of CYP2C19 gene polymorphism in several diseases including IS and subclinical atherosclerosis. 18,19 Gu et al 13 considered that the AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke. Salagacka-Kubiak et al 18 suggested there is some interaction between gender, CYP2C19*2 polymorphism, and pathogenesis of Helicobacter pylori infection development.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Gu et al 13 considered that the AA genotype and A allele of CYP2C19 G681A may be related to the occurrence and recurrence of cerebral ischemic stroke. Salagacka-Kubiak et al 18 suggested there is some interaction between gender, CYP2C19*2 polymorphism, and pathogenesis of Helicobacter pylori infection development. However, the conclusions are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between CYP2C19 gene polymorphisms and lipid metabolism in Chinese patients with ischemic stroke

et al. 2020

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Objective The CYP2C19 genetic variation may be involved in the development of atherosclerotic cardiovascular disease (ASCVD). Serum lipid levels are important risk factors for ASCVD, but the effect of the CYP2C19 gene on serum lipid metabolism remains unclear. This retrospective cohort study investigated the relationship between the CYP2C19 gene polymorphism and serum lipid levels in patients with ischemic stroke (IS). Methods IS patients (n = 230) and control subjects (n = 100) were enrolled. All patients were diagnosed with IS via clinical manifestations and brain magnetic resonance imaging. All patients were genotyped. Results Triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and apolipoprotein B (ApoB) levels were significantly higher and high-density lipoprotein-cholesterol (HDL-c) and apolipoprotein A1 (ApoA1) levels were significantly lower in the IS group compared with the control group. Lower ApoA1 levels and higher ApoB levels were significant predictive factors for IS. Patients with higher ApoB levels had a higher risk of IS recurrence. Compared with extensive metabolizers, intermediate and poor CYP2C19 metabolizers had a higher risk of IS recurrence. Conclusions Our study indicates CYP2C19 gene polymorphisms are related to lipid metabolism in patients with IS. IS patients who are poor CYP2C19 metabolizers may have a higher risk of disease recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between CYP2C19 gene polymorphisms and lipid metabolism in Chinese patients with ischemic stroke

et al. 2020

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“…Esta técnica consiste en la extracción y purificación de ADN, con el producto obtenido se realiza un PCR y posteriormente se revela con electroforesis en gel de agarosa, el producto obtenido de esta reacción se somete a un proceso de digestión por varias horas utilizando enzimas de restricción, los fragmentos obtenidos se identifican por electroforesis, se deben utilizar controles en todas las reacciones (Sałagacka-Kubiak et al, 2019).…”

Section: Polymerase Chain Reaction-restriction Fragment Length Polymo...unclassified

Influencia del polimorfismo de CYP3A4 y CYP3A5 en la farmacocinética de tacrolimus en receptores de trasplante renal. Revisión narrativa

Escobar-Castro¹,

Cáceres²

2021

CTS

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El uso de inhibidores de calcineurina, en particular de tacrolimus como terapia inmunosupresora se ha generalizado a nivel mundial, permitiendo mejorar la tasa de sobrevida del injerto y la calidad de vida del paciente trasplantado. Con el acceso a los estudios de farmacogenética, los grupos de trasplante a nivel mundial se han visto motivados a realizar estudios genéticos que permitan interpretar la influencia de polimorfismos de genes como mTOR, PPP3CA, FKBP1A, FKBP2, y FOXP3, sin embargo, los más estudiados en la población trasplantada para optimizar la dosis de tacrolimus y ciclosporina son los polimorfismos del citocromo p450, CYP3A4 y CYP3A5. El objetivo de la presente revisión narrativa es examinar publicaciones recientes que estudien la relación entre el polimorfismo de CYP3A4/5 y el metabolismo de tacrolimus en pacientes trasplantados renales. Se revisó literatura reciente extraída de los sitios NCBI PubMed y PharmGKB.org en la que se hubiera investigado la influencia de los polimorfismos de CYP3A4/5 en el metabolismo de tacrolimus en trasplantados renales. Se identificó variaciones genéticas de CYP3A4/5 en pacientes trasplantados tratados con tacrolimus que permitirán a los médicos trasplantólogos dosificar de manera precisa el inmunosupresor. El uso de análisis farmacogenéticos permite determinar las variables genéticas del CYP3A4/5, y por lo tanto la toma de decisiones personalizadas en la dosis de inicio y de mantenimiento del inmunosupresor tacrolimus para alcanzar los niveles óptimos y con ello disminuir el riesgo de rechazo, de infecciones asociadas a inmunosupresión, y de toxicidad por el medicamento.

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Genetic polymorphisms of CYP2C19 in ecuadorian population: An interethnic approach

Alonso Llorente,

Salgado Garrido,

Teijido Hermida

et al. 2024

Heliyon

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CYP2C19*2 polymorphism in Polish peptic ulcer patients

Cited by 4 publications

References 23 publications

Association between CYP2C19 gene polymorphisms and lipid metabolism in Chinese patients with ischemic stroke

Association between CYP2C19 gene polymorphisms and lipid metabolism in Chinese patients with ischemic stroke

Influencia del polimorfismo de CYP3A4 y CYP3A5 en la farmacocinética de tacrolimus en receptores de trasplante renal. Revisión narrativa

Genetic polymorphisms of CYP2C19 in ecuadorian population: An interethnic approach

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