CypB promotes cell proliferation and metastasis in endometrial carcinoma

Liu, Jing; Zuo, Ying; Qu, Guimei; Song, Xiao; Liu, Zhonghui; Zhang, Tingguo; Zheng, Zhu-Hua; Wang, Hongkun

doi:10.1186/s12885-021-08374-7

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…The detailed mechanism of action of PPIB/ CypB in carcinogenesis has not yet been fully elucidated. It has been reported that PPIB/ CypB is crucial for proliferation and colony formation and migration of various cancer cells [12,[23][24][25]. Previously, Teng et al demonstrated that CypB expression was significantly higher in NSCLC tissues than in adjacent normal samples.…”

Section: Discussionmentioning

confidence: 99%

PPIB/Cyclophilin B expression associates with tumor progression and unfavorable survival in patients with pulmonary adenocarcinoma

Hwang

2024

Am J Cancer Res

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Cyclophilin B (CypB), encoded by peptidylprolyl isomerase B (PPIB), is involved in cellular transcriptional regulation, immune responses, chemotaxis, and proliferation. Recent studies have shown that PPIB/CypB is associated with tumor progression and chemoresistance in various cancers. However, the clinicopathologic significance and mechanism of action of PPIB/CypB in non-small cell lung cancer (NSCLC) remain unclear. In this study, we used RNA in situ hybridization to examine PPIB expression in 431 NSCLC tissue microarrays consisting of 295 adenocarcinomas (ADCs) and 136 squamous cell carcinomas (SCCs). Additionally, Ki-67 expression was evaluated using immunohistochemistry. The role of PPIB/CypB was assessed in five human NSCLC cell lines. There was a significant correlation between PPIB/CypB expression and Ki-67 expression in ADC (Spearman correlation r=0.374, P<0.001) and a weak correlation in SCC (r=0.229, P=0.007). In ADCs, high PPIB expression (PPIB high ) was associated with lymph node metastasis (P=0.023), advanced disease stage (P=0.014), disease recurrence (P=0.013), and patient mortality (P=0.015). Meanwhile, high Ki-67 expression (Ki-67 high ) was correlated with male sex, smoking history, high pT stage, lymph node metastasis, advanced stage, disease recurrence, and patient mortality in ADC (all P<0.001). However, there was no association between either marker or clinicopathological factors, except for old age and PPIB high (P=0.038) in SCC. Survival analyses revealed that the combined expression of PPIB high /Ki-67 high was an independent prognosis factor for poor disease-free survival (HR 1.424, 95% CI 1.177-1.723, P<0.001) and overall survival (HR 1.266, 95% CI 1.036-1.548, P=0.021) in ADC, but not in SCC. Furthermore, PPIB/CypB promoted the proliferation, colony formation, and migration of NSCLC cells. We also observed the oncogenic properties of PPIB/CypB expression in human bronchial epithelial cells. In conclusion, PPIB/CypB contributes to tumor growth in NSCLC, and elevated PPIB/Ki-67 levels are linked to unfavorable survival, especially in ADC.

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Section: Discussionmentioning

confidence: 99%

PPIB/Cyclophilin B expression associates with tumor progression and unfavorable survival in patients with pulmonary adenocarcinoma

Hwang

2024

Am J Cancer Res

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“…Seismic waves propagating in fractured media exhibit anisotropic characteristics in terms of attributes such as amplitude, velocity, attenuation, and travel time, which can be used to predict the development intensity of fractures by analyzing their azimuthal variation (Shen et al, 2002;Liu et al, 2021b). Various seismic attributes have different resolutions and different ability to identify fractures (Wang et al, 2022).…”

Section: Seismic Attribute Extractionmentioning

confidence: 99%

Distribution pattern of natural fractures in lacustrine shales: a case study of the Fengcheng formation in the Mahu Sag of the Junggar Basin, China

et al. 2023

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The Lower Permian Fengcheng Formation in the Mahu Sag develops a set of organic-rich alkaline lacustrine shale strata, which is a key area for shale oil exploration and development. As an important storage space and seepage channel for shale reservoirs, natural fractures have an impact on shale oil enrichment, production and development effect. In this study, the types and characteristics of natural fractures were first analyzed using core, thin section and imaging logging data. On this basis, combined with the distribution of fractures in single wells, the vertical distribution law of fractures is discussed. Finally, the planar distribution of fractures is evaluated using different seismic attributes such as coherence, curvature, likelihood, and AVAz. The results showed that three types of fractures are existed, including transformational shear fractures, intraformational open fractures and bed-parallel shear fractures, with intraformational open fractures being the most developed. The development degree of fractures in different layers has obvious differences, mainly controlled by lithology and brittle mineral content. The basalt and tuff are developed in the Feng 1 Member, with low carbonate mineral content, resulting in a relatively low degree of fracture development. The dolomite and argillaceous dolomite are developed in the Feng 2 Member and the Feng 3 Member, with high carbonate mineral content and brittleness, resulting in a high degree of fracture development. Additionally, the closer to the fault, the higher the degree of fracture development. On the plane, the fracture zone develops near the main and secondary faults, with the trend mainly oriented in the E-W direction and approximately parallel to the direction of the faults. The width of the fracture zone is largest in the central and southern part of the study area. These fractures are fault-related and are caused by regional stress fields resulting from the activity of the main-secondary faults.

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The PPIase Activity of CypB Is Essential for the Activation of Both AKT/mTOR and XBP1s Signaling Pathways during the Differentiation of 3T3-L1 Preadipocytes

Kim,

Yoon,

et al. 2024

Nutrients

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In this study, we undertook an extensive investigation to determine how CypB PPIase activity affects preadipocyte differentiation and lipid metabolism. Our findings revealed that inhibition of CypB’s PPIase activity suppressed the expression of crucial proteins involved in adipocyte differentiation and induced changes in proteins regulating the cell cycle. Furthermore, we clarified the impact of CypB’s PPIase activity on lipid metabolism via the AKT/mTOR signaling pathway. Additionally, we demonstrated the involvement of CypB’s PPIase activity in lipid metabolism through the XBP1s pathway. These discoveries offer invaluable insights for devising innovative therapeutic strategies aimed at treating and averting obesity and its related health complications. Targeting CypB’s PPIase activity may emerge as a promising avenue for addressing obesity-related conditions. Furthermore, our research opens up opportunities for creating new therapeutic strategies by enhancing our comprehension of the processes involved in cellular endoplasmic reticulum stress.

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CypB promotes cell proliferation and metastasis in endometrial carcinoma

Cited by 3 publications

References 37 publications

PPIB/Cyclophilin B expression associates with tumor progression and unfavorable survival in patients with pulmonary adenocarcinoma

PPIB/Cyclophilin B expression associates with tumor progression and unfavorable survival in patients with pulmonary adenocarcinoma

Distribution pattern of natural fractures in lacustrine shales: a case study of the Fengcheng formation in the Mahu Sag of the Junggar Basin, China

The PPIase Activity of CypB Is Essential for the Activation of Both AKT/mTOR and XBP1s Signaling Pathways during the Differentiation of 3T3-L1 Preadipocytes

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