Cypermethrin exposure during perinatal period affects fetal development and impairs reproductive functions of F1 female rats

Singh, Dipty; Irani, Delna; Bhagat, Sharad; Vanage, Geeta

doi:10.1016/j.scitotenv.2019.135945

Cited by 32 publications

(13 citation statements)

References 40 publications

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“…An altered expression of HOXA10 has also been studied with conflicting results depending on the type of EDC used. A decreased expression of HOXA10 was found following the administration of CP [ 54 ] and endosulfan [ 53 ]; on the contrary, a marked increase compared to the control group was found following contamination with CYP [ 66 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies

Caserta

Costanzi

Marco

et al. 2021

IJERPH

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Several available studies have already analyzed the systemic effects of endocrine-disrupting chemicals (EDCs) on fertile woman and neonatal outcomes, but little is still known in humans about the precise mechanisms of interference of these compounds with the endometrial receptivity. There is consistent evidence that continuous and prolonged exposure to EDCs is a risk factor for reduced fertility and fecundity in women. Preliminary studies on mammalian models provide robust evidence about this issue and could help gynecologists worldwide to prevent long term injury caused by EDCs on human fertility. In this systematic review, we aimed to systematically summarize all available data about EDC effects on blastocyst endometrial implantation. We performed a systematic review using PubMed®/MEDLINE® to summarize all in vivo studies, carried out on mice models, analyzing the molecular consequences of the prolonged exposure of EDC on the implantation process. 34 studies carried out on mouse models were included. Primary effects of EDC were a reduction of the number of implantation sites and pregnancy rates, particularly after BPA and phthalate exposure. Furthermore, the endometrial expression of estrogen (ER) and progesterone receptors (PR), as well as their activation pathways, is compromised after EDC exposure. Finally, the expression of the primary endometrial markers of receptivity (such as MUC1, HOXA10, Inn and E-cadherin) after EDC contact was analyzed. In conclusion EDC deeply affect blastocyst implantation in mouse model. Several players of the implantation mechanism are strongly influenced by the exposure to different categories of EDC.

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Section: Resultsmentioning

confidence: 99%

Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies

Caserta

Costanzi

Marco

et al. 2021

IJERPH

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“…The principal target of pyrethroids is the sodium channels encoded by voltage-sensitive sodium channel gen codes [ 14 , 15 ]. Several studies have also proved that some pyrethroids can act as endocrine disruptors [ 16 , 17 , 18 , 19 ]. In this sense, some agencies, such as the International Agency for Research on Cancer, (IARC) have classified these pesticides according to their toxic effects; these include four organophosphates and the herbicide GLY, which is classified under the group 2A and 2B, “probably/possibly” cancer-causing agents, for instance, considering the limited evidence of carcinogenicity to humans ( Table 2 ) [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Impact of Pesticide Exposure among Rural and Urban Female Population. An Overview

Dahiri

Martín-Reina

Carbonero

et al. 2021

IJERPH

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Pesticides are substances that have become widely used in agriculture and the human exposure to these substances may cause adverse health outcomes. Non-occupational exposure to them can come from many sources, such as food or water. For occupational exposure, many studies have been conducted in men, as they have been mostly in charge of work related to these substances. Nonetheless, the information available concerning the exposure in women is very scarce. In addition, an important differentiation between rural and urban areas has been established, rural areas being known as the most exposed ones due to plantation fields. However, the application of higher concentrations of herbicides in small urban areas is taking a lot of importance currently as well. Regardless of gender, the conditions of exposure, and the environment, the exposure to these pesticides can have different effects on health from early life stages, resulting in different outcomes ranging from neurodevelopmental effects in newborns to different types of cancers. In this review, we discussed the toxicity of the most commonly used pesticides and the main impact on the health of the general population, focusing mainly on the effect in women from both rural and urban areas, and the different stages of development, from pregnancy or lactation to the outcomes of these exposures for their children.

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“… 78 In addition, animal studies show that exposure to pyrethroids increases serum testosterone, a hormone with known antiadipogenic effects. 79 , 80 …”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to insecticides and child cardiometabolic risk factors in the VHEMBE birth cohort

Kim

Yang

Moodie

et al. 2022

Environmental Epidemiology

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Background: As part of malaria control programs, many countries spray dichlorodiphenyltrichloroethane (DDT) or pyrethroid insecticides inside dwellings in a practice called indoor residual spraying that results in high levels of exposure to local populations. Gestational exposure to these endocrine-and metabolism-disrupting chemicals may influence child cardiometabolic health. Methods: We measured the serum concentration of DDT and dichlorodiphenyldichloroethylene (DDE) and urinary concentration of pyrethroid metabolites (cis-DBCA, cis-DCCA, trans-DCCA, 3-PBA) in peripartum samples collected between August 2012 and December 2013 from 637 women participating in the Venda Health Examination of Mothers, Babies and their Environment (VHEMBE), a birth cohort study based in Limpopo, South Africa. We applied marginal structural models to estimate the relationship between biomarker concentrations and child-size (height and weight), adiposity (body mass index [BMI], body fat percentage, waist circumference) and blood pressure at 5 years of age. Results: Maternal concentrations of all four pyrethroid metabolites were associated with lower adiposity including reduced BMI z-scores, smaller waist circumferences, and decreased body fat percentages. Reductions in BMI z-score were observed only among children of mothers with sufficient energy intake during pregnancy (βcis-DCCA, trans -DCCA =−0.4, 95% confidence interval (CI) = −0.7,−0.1; p interaction =0.03 and 0.04, respectively) but there was no evidence of effect modification for the other measures of adiposity. Maternal p,p'-DDT concentrations were associated with a reduction in body fat percentage (β = −0.4%, 95% CI = −0.8,−0.0). Conclusions: Gestational exposure to pyrethroids may reduce adiposity in children at 5 years of age.

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Cypermethrin exposure during perinatal period affects fetal development and impairs reproductive functions of F1 female rats

Cited by 32 publications

References 40 publications

Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies

Effects of Endocrine-Disrupting Chemicals on Endometrial Receptivity and Embryo Implantation: A Systematic Review of 34 Mouse Model Studies

Impact of Pesticide Exposure among Rural and Urban Female Population. An Overview

Prenatal exposure to insecticides and child cardiometabolic risk factors in the VHEMBE birth cohort

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