Cypermethrin triggers apoptosis, depletes granulosa cells, and induces endometrium thinning in female rats

Wardani, Novita Eka Kusuma; Respatiningrum, Respatiningrum; Laili, Anis Nur; Hidayati, Dwi Yuni Nur; Soeharto, Setyawati; Sujuti, Hidayat

doi:10.4103/2305-0500.262830

Asian Pac J Reprod

2019

DOI: 10.4103/2305-0500.262830

|View full text |Cite

Cypermethrin triggers apoptosis, depletes granulosa cells, and induces endometrium thinning in female rats

Novita Eka Kusuma Wardani

Respatiningrum Respatiningrum

Anis Nur Laili

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

αCypermethrin‐Induced Biochemical and Molecular Cascades Underlying Ovine Ovarian Granulosa Cell Dysfunctions

Singh,

Kumar,

Nandi

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

The present study was conducted to evaluate the impact of α‐Cypermethrin (αCYP), the second most commonly used pesticide in India, on the ovine ovarian granulosa cells (GCs) viability, growth, apoptosis, and steroidogenesis. GCs collected from abattoir‐derived ovine ovaries were cultured for 3/6 days in the presence of various concentrations of αCYP (0, 1, 10, 25, 50, and 100 μM). The results revealed a binary effect on GCs, where metabolic activity and viability rates were significantly (p < 0.05) lower from 25 μM onwards. Estrogen concentration was significantly low from the 1 μM dose, whereas progesterone concentration showed a significant increase (10 μM) in the spent media of cultured GCs. The cytotoxicity in the GCs exposed to αCYP revealed significant changes in LDH, ROS, CUPRAC, and GST activity (all at 25 μM) and MDA (at 10 μM) compared to those observed in the control group. The gene expression profiles of cultured GCs showed a significant up‐regulation of CYP11A1, FSHR (all at 1 μM), StAR, BAX, and CASP3 (all at 10 μM), 3βHSD1 (at 25 μM), and significant down‐regulation of CYP17A1 and ERS2 (all at 25 μM), CYP19A1 and 17βHSD (all at 1 μM), ESR1 and BCL2 (all at 10 μM) in comparison to those observed in control groups. The results of the present experiment demonstrated that αCYP affected the growth and functional parameters of GCs, the expression of steroid hormone‐associated genes, and hormone secretion.

show abstract

αCypermethrin‐Induced Biochemical and Molecular Cascades Underlying Ovine Ovarian Granulosa Cell Dysfunctions

Singh,

Kumar,

Nandi

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Cypermethrin triggers apoptosis, depletes granulosa cells, and induces endometrium thinning in female rats

Cited by 1 publication

References 3 publications

αCypermethrin‐Induced Biochemical and Molecular Cascades Underlying Ovine Ovarian Granulosa Cell Dysfunctions

αCypermethrin‐Induced Biochemical and Molecular Cascades Underlying Ovine Ovarian Granulosa Cell Dysfunctions

Contact Info

Product

Resources

About