Cyst Features and Risk of Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Meta-Analysis

Anand, Neeraj; Sampath, Kartik; Wu, Bechien U.

doi:10.1016/j.cgh.2013.02.010

Cited by 186 publications

(140 citation statements)

References 48 publications

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“…The Fukuoka consensus has high sensitivity of the diagnosis of IPMN and prediction of malignancy [57],althoughthecystsizefromthe"high-riskstigmata"to"worrisomefeatures" isstillamatterofcontroversy [57][58][59][60]. A systematic review of the literature suggests that size >3cmincreasedtheriskofmalignancybyapproximately3timesandthepresenceofasolid componentincreasedtheriskofmalignancyapproximatelyeighttimes [58].…”

Section: Challenges In Pancreatic Pathology 82mentioning

confidence: 99%

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Intraductal Papillary Mucinous Neoplasms of the Pancreas: Challenges and New Insights

Carroll¹,

Reyes²,

Vázquez³

2017

Challenges in Pancreatic Pathology

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Cystic lesions of the pancreas are a common entity with almost a 25% incidence of the general population. These types of lesions are being increasingly diagnosed partly explained due to the technological advances over the past years. The management and treatment varies per cyst type. However, the most threatening cyst lesions are intraductal papillary mucinous neoplasms (IPMNs). These lesions represent nowadays a relatively new clinical entity and in many aspects remain poorly understood. The aim of this chapteristoprovideacomprehensivereviewoftheclassification,diagnosis,treatment and follow-up strategy.

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Section: Challenges In Pancreatic Pathology 82mentioning

confidence: 99%

“…A systematic review of the literature suggests that size >3cmincreasedtheriskofmalignancybyapproximately3timesandthepresenceofasolid componentincreasedtheriskofmalignancyapproximatelyeighttimes [58].…”

Section: Challenges In Pancreatic Pathology 82mentioning

confidence: 99%

Intraductal Papillary Mucinous Neoplasms of the Pancreas: Challenges and New Insights

Carroll¹,

Reyes²,

Vázquez³

2017

Challenges in Pancreatic Pathology

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“…Mucinous cystic neoplasm (MCN) represents of 2% of all pancreatic neoplasms and one third of all cystic neoplasms (36). It is mostly a cystic neoplasm of women (female: male ratio is 20:1) and, usually diagnosed at the perimenapousal age.…”

Section: Mucinous Cystic Neoplasm (Mcn)mentioning

confidence: 99%

“…MCN is considered to have a malignant potential. However, malignant transformation happens, at the most 15% (8% to 29-36%) of the patients eventually and the risk is very low in cysts with a diameter less than 30 mm without mural nodules (36). Aspirated fluid, traditionally, reveals high CEA (over 200 ng/mL).…”

Section: Mucinous Cystic Neoplasm (Mcn)mentioning

confidence: 99%

“…It was reported that decreasing amylase, rather than increasing CEA may point towards a malignant transformation, because proliferation of tissue obstructs the communication between the cyst and the duct (42). In branch duct (BD)-IPMN, if the cyst size is below 30 mm, the MPD diameter is less than 6 mm, and mural nodules are absent, the malignancy risk is very low (36). Mural nodules are internal projections of papillary tissue.…”

Section: Turk J Gastroenterol 2014; 25: 1-18mentioning

confidence: 99%

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Management of cystic diseases of the pancreas

Şentürk

2014

Turk J Gastroenterol

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Pancreatic cysts are challenging to the gastroenterologist. Detection rate is increasing and neither criteria for a definitive diagnosis, nor a validated surveillance strategy is available. Pancreatic endosonography with or without sampling is necessary in most of the cases. However this technique requires expertise and is not widely available. While some cysts have a malignant potential or already malign at the diagnosis, most are benign and remain so for decades. We are going to review the existing data on this controversial subject.

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