Cystadenocarcinoma and carcinoembryonic antigen (CEA)

Ferrer, Jose P.; Hensley, George T.; Kalser, Martin H.; Zeppa, Robert

doi:10.1002/1097-0142(197808)42:2<632::aid-cncr2820420233>3.0.co;2-n

Cited by 16 publications

(1 citation statement)

References 3 publications

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“…16,41 MCNs were then found to have higher levels of cyst fluid CEA; however, serum CEA levels were not always elevated in these patients. [41][42][43] Since the publication of a multicenter prospective study by Brugge et al 20 showing that an optimal cyst fluid CEA cutoff of 192 ng/mL was capable of differentiating MCNs from NMCNs, there has been widespread use and availability of the cyst fluid CEA assay for cyst differentiation.…”

Section: Discussionmentioning

confidence: 93%

Suboptimal accuracy of carcinoembryonic antigen in differentiation of mucinous and nonmucinous pancreatic cysts: results of a large multicenter study

Gaddam

Keach

et al. 2015

Gastrointestinal Endoscopy

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Section: Discussionmentioning

confidence: 93%

Suboptimal accuracy of carcinoembryonic antigen in differentiation of mucinous and nonmucinous pancreatic cysts: results of a large multicenter study

Gaddam

Keach

et al. 2015

Gastrointestinal Endoscopy

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Elevated carcinoembryonic antigen levels in the milk of a nursing mother with inoperable breast cancer

Bartal

Kahana

Yarom

1980

Cancer

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Carcinoembryonic antigen (CEA) determinations performed in the milk of a nursing mother with an inoperable breast cancer revealed a 10-15-fold higher level compared with CEA levels in the milk of healthy nursing women. CEA was highly elevated in the milk of the tumor-bearing breast (1100 ? 100 ng/ml) and moderately elevated in the milk of the clinically nonaffected breast (700 ? 50 ng/ml). However, serum CEA levels were within normal range (9.8 ? 0.5 ng/ml). The various theoretical and practical implications of this finding, including considerations for early breast cancer detection, are discussed.Cancer Case ReportA 44-year-old Arabic woman, mother of 13 children and living in a small village, noticed a mass in her left breast during pregnancy. She did not ask for medical advice then and gave birth to a normal baby. Shortly thereafter she became pregnant again and during this pregnancy she noticed the breast mass had grown, causing local irritation. Again she delivered a normal baby, but it was only eight months later, while still nursing her child. that she was first examined by a physician. A huge inoperable mass was palpated in her left breast: it caused nipple retraction and infiltrated the skin above. Enlarged lymph nodes were found in the left supraclavicular fossa and in the left axilla. No definite mass could be palpated in the right breast. The rest of the physical examination was normal. A biopsy of the left breast mass showed a poorly differentiated ductal carcinoma of infiltrative nature. Blood chemistry tests, gastrointestinal tract, chest radiograms, and bone and liver scans were within normal limits. The patient started hormonal treatment by testosterone injections, radiological castration, and thereafter two courses of combination chemotherapy consisting of Cytoxan, methotrexate, and 5-fluorouracil (CMF). Following therapy, marked improvement was noticed with partial regression of the tumor and lymph nodes. Prior to radiotherapy, serum and milk from both breasts was taken to determine CEA levels. CEA was measured by radioimmunoassay with a commercial kit ("CEA Ire Sorin," Commissariat a 1'Energie Atomique GIF-Sur Yvette, France). Normal serum CEA values in our laboratory went up to 15 ngirnl. To our surprise, the milk from the left breast revealed a high CEA level of 1100 :t 100 ngiml; in the right breast it was moderately elevated to 700 ? 50 ngirnl. The serum CEA level, however, was 9.8 2 0.5 ng/ml. The mean and S . D . of CEA levels in milk of 43 healthy nursing women, 2-20 days postpartum, were 66.4 t 55.6 ndml (range of 5.0-252.0 ngiml). Following radiotherapy, the milk stopped flowing. DiscussionT h e only study concerning CEA determination in milk was that of Pusztaszri and Mach," who reported a CEA level of 150 ngiml in the colostrum of only one out of five women, five days postpartum, by a double diffusion method. To the best of our knowledge no other study of CEA levels, either in normal milk o r

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Carcinoembryonic antigen in gastric juice as an aid in diagnosis of early gastric cancer

Tatsuta

Itoh

Okuda

et al. 1980

Cancer

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The levels of carcinoembryonic antigen (CEA) in the serum and gastric juice of 58 patients with gastric cancer were determined by radioimmunoassay. The level of serum CEA was not a satisfactory indicator of gastric cancer: it was elevated in only 19.4% of the cases of advanced and unresectable cancer and 4.5% of cases of early cancer examined. However, the CEA level in the gastric juice was significantly higher in patients with gastric cancer than in normal subjects or patients with benign gastric diseases: increased CEA concentrations and outputs in the gastric juice were observed in 54.5% and 40.1%, respectively, of the patients with early gastric cancer, and in 52.9% and 50.0%, respectively, of the patients with advanced gastric cancer. The gross type of gastric cancer had no influence on the gastric CEA level, but the CEA level in the gastric juice tended to be high when the tumors were large, or when they had little or no glandular structure or high mucus-secreting activity.

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Cystadenocarcinoma and carcinoembryonic antigen (CEA)

Cited by 16 publications

References 3 publications

Suboptimal accuracy of carcinoembryonic antigen in differentiation of mucinous and nonmucinous pancreatic cysts: results of a large multicenter study

Suboptimal accuracy of carcinoembryonic antigen in differentiation of mucinous and nonmucinous pancreatic cysts: results of a large multicenter study

Elevated carcinoembryonic antigen levels in the milk of a nursing mother with inoperable breast cancer

Carcinoembryonic antigen in gastric juice as an aid in diagnosis of early gastric cancer

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