Cystadenocarcinoma of salivary gland presenting as a cystic lesion in the mandible

Johnston, N.J.; Rose, D.S.C.; Lutterloch, M.J.

doi:10.1016/j.tripleo.2005.08.027

Cited by 25 publications

(6 citation statements)

References 7 publications

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“…These findings corroborate with descriptions in humans (Nakagawa et al, 2002;Johnston et al, 2006;Yamada et al, 2007).…”

Section: Discussionsupporting

confidence: 92%

“…Cystadenocarcinoma was reported for the first time as a rare adenocarcinoma variant in animals (Head et al, 2002). This tumor has been widely described in human medicine (Shrestha et al, 1994;Johnston et al, 2006;Aloudah et al, 2008;Gallego et al, 2008) and is macroscopically characterized by the formation of masses with varied colors and slow growth which may present cystic areas with mucous content and discrete necrosis (Johnston et al, 2006;Gallego et al, 2008). Microscopically, it refers to a neoplasm composed of several cysts, which may present papillary projections and sometimes red blood cells inside the cysts (Johnston et al, 2006;Gallego et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…This tumor has been widely described in human medicine (Shrestha et al, 1994;Johnston et al, 2006;Aloudah et al, 2008;Gallego et al, 2008) and is macroscopically characterized by the formation of masses with varied colors and slow growth which may present cystic areas with mucous content and discrete necrosis (Johnston et al, 2006;Gallego et al, 2008). Microscopically, it refers to a neoplasm composed of several cysts, which may present papillary projections and sometimes red blood cells inside the cysts (Johnston et al, 2006;Gallego et al, 2008). Most of these tumors produce a mucoid substance, and histochemical techniques such as Periodic Acid Schiff (PAS) or Mayer's Mucicarmine stain (Pollet et al, 1997) evidence this type of material.…”

Section: Introductionmentioning

confidence: 99%

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Cystadenocarcinoma simulating hemangiosarcoma of the salivary gland in dog: case report

Gamba¹,

Damasceno²,

Campos³

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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Cystadenocarcinoma is regarded as a rare adenocarcinoma variant in animals. This work reports the case of an 8-year-old female Poodle dog with salivary gland cystadenocarcinoma with morphological characteristics similar to a hemangiosarcoma. Histopathological analysis showed a tumor mass with cystic formations containing a large amount of red blood cells. In order to distinguish these two entities, periodic acid Schiff (PAS) staining and immunohistochemical analysis were carried out with the use of cytokeratin AE1/AE3 (CK) and CD31-specific antibodies. Neoplastic cells were PAS-negative, CKpositive and CD31-negative confirming their epithelial origin. Based on the findings, the diagnosis of high grade cystadenocarcinoma was established.

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“…These findings corroborate with descriptions in humans (Nakagawa et al, 2002;Johnston et al, 2006;Yamada et al, 2007).…”

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cystadenocarcinoma simulating hemangiosarcoma of the salivary gland in dog: case report

Gamba¹,

Damasceno²,

Campos³

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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“…Cystadenocarcinomas of salivary glands are a rare and morphologic heterogeneous group of neoplasms characterized by prominent cystic appearance-often with complex papillary architecture-infiltrative growth, and absence of myoepithelial cells [17][18][19][20][21]. Although most cystadenocarcinomas are low grade malignancies composed of small cuboidal cells with scanty cytoplasm displaying regular nuclei with inconspicuous nucleoli, and low mitotic activity [17,20,21], others exhibit large cuboidal or columnar cells with moderate to high nuclear atypia, prominent nucleoli, and frequent mitoses [17,18,22], and lastly, some are best classified as mucinous cystadenocarcinoma [22][23][24].…”

Section: Cystadenocarcinomamentioning

confidence: 99%

“…Although most cystadenocarcinomas are low grade malignancies composed of small cuboidal cells with scanty cytoplasm displaying regular nuclei with inconspicuous nucleoli, and low mitotic activity [17,20,21], others exhibit large cuboidal or columnar cells with moderate to high nuclear atypia, prominent nucleoli, and frequent mitoses [17,18,22], and lastly, some are best classified as mucinous cystadenocarcinoma [22][23][24].…”

Section: Cystadenocarcinomamentioning

confidence: 99%

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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Low-grade salivary duct carcinoma (LG-SDC) is a rare neoplasm characterized by predominant intraductal growth, luminal ductal phenotype, bland microscopic features, and favorable clinical behavior with an appearance reminiscent of florid to atypical ductal hyperplasia to low grade intraductal breast carcinoma. LG-SDC is composed of multiple cysts, cribriform architecture with ''Roman Bridges'', ''pseudocribriform'' proliferations with floppy fenestrations or irregular slits, micropapillae with epithelial tufts, fibrovascular cores, and solid areas. Most of the tumor cells are small to medium sized with pale eosinophilic cytoplasm, and round to oval nuclei, which may contain finely dispersed or dark condensed chromatin. Foci of intermediate to high grade atypia, and invasive carcinoma or micro-invasion have been reported in up to 23 % of cases. The neoplastic cells have a ductal phenotype with coexpression of keratins and S100 protein and are surrounded by a layer of myoepithelial cells in noninvasive cases. The main differential diagnosis of LG-SDC includes cystadenoma, cystadenocarcinoma, sclerosing polycystic adenosis, salivary duct carcinoma in situ/highgrade intraductal carcinoma, and papillary-cystic variant of acinic cell carcinoma. There is no published data supporting the continuous classification of LG-SDC as a variant of cystadenocarcinoma. Given that most LG-SDC are noninvasive neoplasms; the terms ''cribriform cystadenocarcinoma'' and LG-SDC should be replaced by ''low-grade intraductal carcinoma'' (LG-IDC) of salivary gland or ''lowgrade intraductal carcinoma with areas of invasive carcinoma'' in those cases with evidence of invasive carcinoma.

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Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review

Kawahara

Harada

Mihashi

et al. 2010

Diagnostic Cytopathology

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Cystadenocarcinoma is a rare malignant tumor, with an estimated incidence of 2% of malignant salivary gland tumors. Cytological diagnosis of cystadenocarcinoma is important for differential diagnosis between benign lesions and malignant tumors with cystic growth. We report a case of cystadenocarcinoma causing difficulty in cytological diagnosis. A 23-year-old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years. The mass was elastic hard, measuring 30 x 35 mm in diameter. Preoperative fine-needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid. The cluster was arranged in a ball-like structure and was cohesive with overlapping. Tumor cells had a small vacuolated, soap-bubble appearance in the cytoplasm. The papillary-cystic variant of acinic cell carcinoma (ACC-PCV) was suggested from these findings on FNAC. Histologically, the tumor was not encapsulated, but formed large cystic spaces against a background of fibrous connective tissue. The tumor cells in the cystic dilated duct showed papillary structures, which were continuous with the lining cuboidal cells. There was neither a definite double-layered arrangement in cystic ducts and solid islands nor histological findings characteristic of the papillary-cystic or follicular pattern of ACC-PCV. As tumor cells with a small vacuolated, soap-bubble appearance of the cytoplasm are common findings of both cystadenocarcinoma and ACC-PCV, they are of little use for differentiation; however, they are so characteristic that the majority of benign salivary gland lesions with cystic structures can be excluded, if enough attention is paid.

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Cystadenocarcinoma of salivary gland presenting as a cystic lesion in the mandible

Cited by 25 publications

References 7 publications

Cystadenocarcinoma simulating hemangiosarcoma of the salivary gland in dog: case report

Cystadenocarcinoma simulating hemangiosarcoma of the salivary gland in dog: case report

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review

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