Cystatin C

Deyà‐Martínez, Àngela; Fortuny, Clàudia; Soler‐Palacín, Pere; Neth, Olaf; Sánchez, Emília; Martin‐Nalda, Andrea; Falcón-Neyra, Lola; Vilà, A; Valls, A.; Noguera-Julián, Antoni

doi:10.1097/inf.0000000000000960

Cited by 16 publications

(15 citation statements)

References 39 publications

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“…These findings accorded with our observations of cystatin C levels and COVID-19. Of note, a multicenter cohort study of pediatric subjects infected by human immunodeficiency viruses (HIV) demonstrated that cystatin C levels were strongly related to kidney function and inflammatory state [ 34 ]. Positive relevance of elevating cystatin C levels to plasma HIV RNA status was also observed in adult patients with HIV infection whose antiretroviral therapy was randomly interrupted [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients

Chen

Sun

et al. 2020

Mediators of Inflammation

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This study aimed at determining the relationship between baseline cystatin C levels and coronavirus disease 2019 (COVID-19) and investigating the potential prognostic value of serum cystatin C in adult patients with COVID-19. 481 patients with COVID-19 were consecutively included in this study from January 2, 2020, and followed up to April 15, 2020. All clinical and laboratory data of COVID-19 patients with definite outcomes were reviewed. For every measure, COVID-19 patients were grouped into quartiles according to the baseline levels of serum cystatin C. The highest cystatin C level was significantly related to more severe inflammatory conditions, worse organ dysfunction, and worse outcomes among patients with COVID-19 (P values < 0.05). In the adjusted logistic regression analyses, the highest cystatin C level and ln-transformed cystatin C levels were independently associated with the risks of developing critically ill COVID-19 and all-cause death either in overall patients or in patients without chronic kidney disease (P values < 0.05). As a potential inflammatory marker, increasing baseline levels of serum cystatin C might independently predict adverse outcomes for COVID-19 patients. Serum cystatin C could be routinely monitored during hospitalization, which showed clinical importance in prognosticating for adult patients with COVID-19.

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Section: Discussionmentioning

confidence: 99%

Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients

Chen

Sun

et al. 2020

Mediators of Inflammation

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“…Both cytokines have been increased in our experiment by CP, an action that was significantly antagonized by sesamin treatment. Cystatin, in addition to being a reliable renal biomarker in both acute kidney injury and chronic kidney disease (Ali et al 2018), is also considered a biomarker for inflammation (Deyà-Martínez et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Sesamin in Cisplatin-Induced Nephrotoxicity in Rats by Suppressing Inflammation, Oxidative/Nitrosative Stress, and Cellular Damage

et al. 2020

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Nephrotoxicity of cisplatin (CP) involves renal oxidative stress and inflammation, and sesamin (a major liganin in many plants) has strong antioxidant and antiinflammatory actions. Therefore, we investigated here the possible mitigative action of sesamin on CP nephrotoxicity in rats. Sesamin was given orally (5 mg/kg/day, 10 days), and on the 7th day, some of the treated rats were injected intraperitoneally with either saline or CP (5 mg/kg). On the 11th day, rats were sacrificed, and blood and urine samples and kidneys were collected for biochemical estimation of several traditional and novel indices of renal damage in plasma and urine, several oxidative and nitrosative indices in kidneys, and assessment of histopathological renal damage. CP significantly and adversely altered all the physiological, biochemical and histopathological indices of renal function measured. Kidneys of CP‐treated rats had a moderate degree of necrosis. This was markedly lessened when CP was given simultaneously with sesamin. Sesamin treatment did not significantly alter the renal CP concentration. The results suggested that sesamin had ameliorated CP nephrotoxicity in rats by reversing the CP-induced oxidative stress and inflammation. Pending further pharmacological and toxicological studies sesamin may be considered a potentially useful nephroprotective agent.

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“…Similar to the serum CysC, increased urinary CysC has been recognized as a marker of renal tubular dysfunction [ 65 ]. Urinary CysC concentration has been found to be increased in HIV subjects [ 42 ] and to correlate with GFR and B2-M in patients with HIV infection [ 66 ]. Urinary CysC/Cr also correlates with urinary RBP/Cr, suggesting that CysC may be better markers of specific forms of proximal tubular dysfunction in these patients [ 27 ].…”

Section: Cystatin Cmentioning

confidence: 99%

“…Urinary CysC/Cr also correlates with urinary RBP/Cr, suggesting that CysC may be better markers of specific forms of proximal tubular dysfunction in these patients [ 27 ]. It has been also suggested that CysC may be useful as a marker of renal function in HIV-infected patients, independently of ongoing inflammation or viremia [ 66 ].…”

Section: Cystatin Cmentioning

confidence: 99%

Urinary Markers of Tubular Injury in HIV-Infected Patients

Fiseha

Gebreweld

2016

Biochemistry Research International

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Renal disease is a common complication of HIV-infected patients, associated with increased risk of cardiovascular events, progression to AIDS, AIDS-defining illness, and mortality. Early and accurate identification of renal disease is therefore crucial to improve patient outcomes. The use of serum creatinine, along with proteinuria, to detect renal involvement is essentially to screen for markers of glomerular disease and may not be effective in detecting earlier stages of renal injury. Therefore, more sensitive and specific markers are needed in order to early identify HIV-infected patients at risk of renal disease. This review article summarizes some new and important urinary markers of tubular injury in HIV-infected patients and their clinical usefulness in the renal safety follow-up of TDF-treated patients.

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Cystatin C

Abstract: Cystatin C values were associated with GFR and β-2-microglobulin. Cystatin C may be useful as a marker of renal function in HIV-infected pediatric patients, independently of ongoing inflammation or viremia.

Cited by 16 publications

References 39 publications

Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients

Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients

Ameliorative Effect of Sesamin in Cisplatin-Induced Nephrotoxicity in Rats by Suppressing Inflammation, Oxidative/Nitrosative Stress, and Cellular Damage

Urinary Markers of Tubular Injury in HIV-Infected Patients

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