Cystatin C: a predictor of hepatorenal syndrome in patients with liver cirrhosis

Sharawey, Mohammed A.; Shawky, Eglal M.; Ali, Lamia H; Mohammed, Ali A.; Hassan, Hatem; Fouad, Yasser

doi:10.1007/s12072-011-9266-y

Cited by 35 publications

(34 citation statements)

References 32 publications

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“…For this reason, dilution hyponatremia and low sodium output in the urine are expected to be very common in patients with HRS. This association has been confirmed by published data [4][5][6] . It is however necessary to rule out, pseudohyponatremia in acute on chronic liver failure 21 .…”

Section: Discussionsupporting

confidence: 84%

“…Two studies found serum sodium was not a significant, independent HRS predictor 5,8 and two did 3,9 . The fifth paper was only a case-control design 10 .…”

Section: Introductionmentioning

confidence: 95%

“…The actual risk factors for HRS are much less studied. There are several papers documenting that patients with HRS have lower mean values of serum sodium [4][5][6] but this association does not necessarily mean that serum sodium also has any predictive value.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of hepatorenal syndrome in alcoholic liver cirrhosis

Janíčko¹,

Veselíny²,

Senajová³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Alcoholic liver disease is a major cause of liver cirrhosis and the hepatorenal syndrome is a serious complication. Risk factors for hepatorenal syndrome (HRS) in alcoholic liver cirrhosis are not entirely explored. Aim. To assess the risk factors for hepatorenal syndrome in alcoholic liver cirrhosis. Patients and Methods. Consecutive patients with alcoholic liver disease were followed for two months, development of renal failure, classified either as HRS or renal failure not fulfilling criteria of HRS, was the main outcome. Results. Of 171 patients, 14 (8.2%) developed HRS and 13 (7.6%), renal failure not fulfilling the HRS criteria. A significant difference was found between patients with and without HRS in serum sodium (131.1±3.8 vs. 135.7±5.2; P = 0.003), creatinine, (94.1±26.8 vs. 80.3±20.2; P < 0.001), albumin (23.5±4.9 vs. 29.9±5.8; P < 0.001), INR (1.76±0.45 vs. 1.44±0.41; P < 0.001), bilirubin (252.3±179.4 vs. 91.2±101.0; P < 0.001), MELD (23±6 vs 15±5; P < 0.001) and MELD-Na score (27±5 vs. 18±6; P < 0.001). Multivariate analysis adjusted for sex and age showed that sodium together with creatinine are the strongest HRS predictors, followed by bilirubin with respective odds´ ratios (95% CI) of 1.041 (1.012-1.072) for creatinine, 0.870 (0.766-0.988) for serum sodium and 1.005 (1.001-1.010) for serum bilirubin. Conclusion. Serum levels of sodium, creatinine and bilirubin are important predictors of the hepatorenal syndrome.

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Section: Discussionsupporting

confidence: 84%

“…Two studies found serum sodium was not a significant, independent HRS predictor 5,8 and two did 3,9 . The fifth paper was only a case-control design 10 .…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Predictors of hepatorenal syndrome in alcoholic liver cirrhosis

Janíčko¹,

Veselíny²,

Senajová³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Studies have suggested that serum cystatin C is a more sensitive marker of GFR than SCr since it freely crosses the glomerular membrane to be reabsorbed and metabolized in the proximal tubular cells, without being eliminated [7]. Cystatin C has been also shown to be a predictor of HRS and mortality in patients with liver cirrhosis and ascites [9].…”

Section: Discussionmentioning

confidence: 99%

“…Other tubular proteins unregulated by injury include Neutrophil Gelatinase-Associated Lipocalin (NGAL), Kidney injury molecule 1 (KIM-1), and Liver-type fatty acid binding protein (L-FABP) [7][8][9][10]. In animal models, NGAL is released in the urine following an ischemic or nephrotoxic insult.…”

Section: Discussionmentioning

confidence: 99%

Kidney Biomarkers in Hepatorenal Syndrome

Freeman¹

2017

GHOA

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Cirrhosis is the result of advanced liver disease characterized by fibrosis due to increased portal hypertension. Patients with cirrhosis are prone to develop acute kidney injury (AKI) triggered by bacterial infections, hypovolemia, nephrotoxic drugs and intrinsic kidney disease. The diagnostic criteria for the diagnosis of HRS continue to rely on serum creatinine levels which should be interpreted with caution in patients with cirrhosis. To date, accurate biomarkers indicative of renal function are lacking. Further validation with prospective studies is warranted to evaluate the value of novel biomarkers.

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Plasma cystatin C is a predictor of renal dysfunction, acute‐on‐chronic liver failure, and mortality in patients with acutely decompensated liver cirrhosis

et al. 2017

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Baseline CysC is a biomarker of RD, HRS, and ACLF and an independent predictor of mortality in patients with acutely decompensated liver cirrhosis, though determining CysC at day 3 did not provide any benefit; while NGAL is also associated with short-term mortality, it fails to predict development of RD, HRS, and ACLF. Baseline CysC may help to identify patients at risk earlier and improve clinical management. (Hepatology 2017;66:1232-1241).

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Cystatin C: a predictor of hepatorenal syndrome in patients with liver cirrhosis

Abstract: Serum CysC level may be considered a predictor of HRS and mortality in patients with liver cirrhosis and ascites.

Cited by 35 publications

References 32 publications

Predictors of hepatorenal syndrome in alcoholic liver cirrhosis

Predictors of hepatorenal syndrome in alcoholic liver cirrhosis

Kidney Biomarkers in Hepatorenal Syndrome

Plasma cystatin C is a predictor of renal dysfunction, acute‐on‐chronic liver failure, and mortality in patients with acutely decompensated liver cirrhosis

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