Cystatin-C and Fibronectin as key predictor of glomerulonephritis induced in male rats

Luaibi, Hayder Hussein; Alabbassi, Mustafa Ghazi; Raoof, Israa Burhan

doi:10.5958/0974-360x.2020.00029.3

Cited by 2 publications

(2 citation statements)

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“…In the current study, cystatin C was measured, which is filtered by the renal glomeruli and completely reabsorbed by the proximal renal tubule and has a higher molecular size than creatinine (Suzuki et al, 2012), thus, cystatin C is more predictive of events that occur in the kidneys than creatinine or GFR (Vigil et al, 2014). Luaibi et al (2020), Dabbi and Hussain (2021) also confirmed that there is a significant correlation between serum cystatin C, urea and creatinine.…”

Section: Discussionsupporting

confidence: 67%

Histophysiological Effect of Rosuvastatin on the Kidney in Male Albino Rats

Imad Al-Sultani,

Obaid Hussain,

Shakir Saleh

2023

AAVS

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The objective of the current study was to evaluate the physiological and histopathological effects of rosuvastatin in male albino rats. Thirty-two adult albino rats were used in the study. After acclimatization, the rats were randomly divided into four groups (8 rats in each group) as follows: The first control group was given normal saline solution, the second group 10 mg/kg rosuvastatin, the third group was given 20 mg/kg rosuvastatin, while the fourth group was given 40 mg/kg rosuvastatin. The dose was continued for 60 days in a once-daily dosing regimen. After the end of the experiment, chemical analyses were performed for kidney function, including cystatin C and vitamin D 3 . Then, the rats were dissected, and kidney tissues were taken for histological study. Male rats treated with rosuvastatin showed an elevated cystatin C level and increased vitamin D 3 . At the same time, the results of the microscopic examination showed significant histopathological changes in the kidneys of the groups treated with rosuvastatin compared to the control group, which included mild, moderate, and severe injuries: necrosis, congestion, hemorrhage, glomerular degeneration, fatty changes, cysts and vacuoles in the renal tubule cells and lymphocytic infiltration in the kidney tissue with gradual increase in rosuvastatin concentrations 10, 20 and 40 mg/kg, respectively. Conclusion: It was concluded in the current study that the use of rosuvastatin in high doses causes nephrotoxicity.

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Section: Discussionsupporting

confidence: 67%

Histophysiological Effect of Rosuvastatin on the Kidney in Male Albino Rats

Imad Al-Sultani,

Obaid Hussain,

Shakir Saleh

2023

AAVS

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“…At the end of the experiment, the animals were anesthetized by a cocktail of 100 mg/kg ketamine plus 10 mg/kg xylazine in the I.M route which was used in the previous study and show optimal results 25 . Kidneys were removed and placed in the formalin 10%.…”

Section: Methodsmentioning

confidence: 99%

Assessment of New Protected Mechanism of Liraglutide on CKD Progression

Luaibi¹,

Alabbassi²,

Raoof³

et al. 2021

PBJ

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Podocyte injury represents the main reason for proteinuria and renal disease in diabetic and non-diabetic patients. Recently Liraglutide as a GLP-1 analog is hypothesized to play a vital role in preventing kidney damage by antiinflammatory and anti-apoptotic effect mechanisms. This study was established to evaluate the effect of Liraglutide on deterioration that happens with time in chronic kidney disease. 36 male Wister rats with a weight of 250-300 g were used in this study. All selected animals were examined and determined to be normal on general examination. Rats were divided into three groups (12rats/group): control group: negative control group injected normal saline I.P, induction group: single I.P dose (7.5 mg/kg) of doxorubicin for 14 days then administered 0.5ml/kg normal saline intraperitoneal for 28 days, and treatment group: single I.P dose (7.5 mg/kg) of doxorubicin for 14 days then administered I.P Liraglutide 200μg/kg/day freshly dissolve in 0.5ml /kg normal saline 28 days. The treatment group appeared significantly decreased (P< 0.05) in the pro-inflammatory expression of TNF-α as compared with the induction group, while the treatment group revealed a significant increased (P< 0.05) in the expression of anti-apoptotic BCL-2 in the proximal tubule of the kidney. Besides the effect of Liraglutide on renal deterioration by lowering blood glucose, the main causes of oxidative stress, Liraglutide as GLP-1 analog can reduce the consequence of proteinuria in the cases of glomerulosclerosis and tubulointerstitial damage by decreased pro-inflammatory TNF-α expression and increase expression of BCL-2 in that cell.

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Cystatin-C and Fibronectin as key predictor of glomerulonephritis induced in male rats

Cited by 2 publications

References 0 publications

Histophysiological Effect of Rosuvastatin on the Kidney in Male Albino Rats

Histophysiological Effect of Rosuvastatin on the Kidney in Male Albino Rats

Assessment of New Protected Mechanism of Liraglutide on CKD Progression

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