Cystatin C and intravenous thrombolysis

Peng, Meidi; Chen, Yu-Pei; Geng, Guiling

doi:10.1111/ene.14722

Cited by 2 publications

(1 citation statement)

References 3 publications

(4 reference statements)

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“…,e value of serum D-dimer levels in the assessment of intracranial aneurysms occurrence and risk of rupture is currently unclear. Cystatin C is one of the cysteines cathepsin inhibitory proteins and is mainly used as a marker reflecting impaired renal function [13][14][15]. Cystatin C can potently inhibit cathepsin, and when the level of cystatin C decreases, the activity of cathepsin increases, which may lead to excessive decomposition of the extracellular matrix of the blood vessel wall, resulting in pathological damage [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

A Computational Model of Blood D-Dimer, Cystatin C, and CRP Levels Predicts the Risk of Intracranial Aneurysms and their Rupture

Lü

Long

et al. 2022

Computational Intelligence and Neuroscience

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Objective. The aim of this study is to construct a computational model of blood D-dimer, cystatin C, and CRP levels and to predict the risk of intracranial aneurysms and their rupture. Methods. A total of 69 intracranial aneurysms patients were selected as the case group, including 28 cases in the ruptured group and 41 cases in the unruptured group. Another 64 non-intracranial aneurysm patients were selected as the control group. The detection results of serum D-dimer, cystatin C, and CRP were collected. The logistic regression computational model was used to analyze the occurrence and risk factors of intracranial aneurysms. The receiver operating curves (ROC) of serum D-dimer, cystatin C, and C reactive protein (CRP) levels for predicting intracranial aneurysms and their rupture were drawn, and the area under the curve (AUC), sensitivity, and specificity were calculated. Results. The serum levels of D-dimer, cystatin C, and CRP in patients with intracranial aneurysms were significantly higher than those in the control group and the differences were statistically significant P < 0.05 . The serum levels of D-dimer, cystatin C, and CRP in patients with ruptured intracranial aneurysms were higher than those in patients with unruptured intracranial aneurysms, and the differences were also statistically significant P < 0.05 . The combined detection of serum D-dimer, cystatin C, and CRP levels has a higher AUC (0.9014) for predicting intracranial aneurysms and higher AUC (0.9412) for predicting ruptured intracranial aneurysms than D-dimer (0.7118 and 0.8750, respectively), cystatin C (0.6489 and 0.6180, respectively), and CRP (0.7764 and 0.6551, respectively) independent detection; the combined detection had a sensitivity of 93.75% and 87.80 for predicting the occurrence and rupture of intracranial aneurysms, and the specificity was 68.12% and 92.86%, respectively. Conclusion. The combined detection of serum D-dimer, cystatin C, and CRP levels is a very valuable indicator for predicting the occurrence and rupture of intracranial aneurysms, and combined detection can provide scientific evidence-based guidance for clinical prediction of the occurrence and rupture of intracranial aneurysms.

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