Cystatin C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney injury after congenital heart surgery

Seitz, Stefanie; Rauh, Manfred; Gloeckler, Martin; Cesnjevar, Robert; Dittrich, Sven; Koch, Andreas

doi:10.4414/smw.2013.13744

Cited by 22 publications

(32 citation statements)

References 22 publications

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“…Previous studies in the recent literature have evaluated serum Cys C as an early marker of AKI, as well as its severity, in children sustaining AKI secondary to CPB . They have shown that it is a good marker.…”

Section: Discussionmentioning

confidence: 99%

“…There is increasing evidence that serum Cys C can be used as an early biomarker of AKI resulting from CPB . Multiple studies have evaluated its performance in comparison with serum Cr . A potential limitation of these studies is that they define AKI based on increase in serum Cr or decrease in Cr‐based GFR measurements.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Multiple studies have evaluated its performance in comparison with serum Cr. [7][8][9][10][11] A potential limitation of these studies is that they define AKI based on increase in serum Cr or decrease in Cr-based GFR measurements. Recent evidence suggests that urinary neutrophil gelatinase-associated lipocalin (NGAL) is a more specific and sensitive early marker of AKI in this patient population.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum Cystatin C as an Early Marker of Neutrophil Gelatinase-associated Lipocalin-positive Acute Kidney Injury Resulting from Cardiopulmonary Bypass in Infants with Congenital Heart Disease

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum Cystatin C as an Early Marker of Neutrophil Gelatinase-associated Lipocalin-positive Acute Kidney Injury Resulting from Cardiopulmonary Bypass in Infants with Congenital Heart Disease

et al. 2015

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“…The postoperative cystatin C level also independently predicted longer duration of ventilation and intensive care unit stay [46]. Other recent reports have provided confirmatory results, albeit with a slightly reduced AUC of 0.71–0.81 [47–49]. A recent multicenter prospective cohort study assessed the change in tubular injury biomarkers of AKI with changes in cystatin C in children undergoing cardiac surgery with CPB [50].…”

Section: Novel Diagnostic Strategies In Akimentioning

confidence: 98%

Early detection of acute kidney injury after pediatric cardiac surgery

Jefferies

Devarajan

2016

Progress in Pediatric Cardiology

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Acute kidney injury (AKI) is increasingly recognized as a common problem in children undergoing cardiac surgery, with well documented increases in morbidity and mortality in both the short and the long term. Traditional approaches to the identification of AKI such as changes in serum creatinine have revealed a large incidence in this population with significant negative impact on clinical outcomes. However, the traditional diagnostic approaches to AKI diagnosis have inherent limitations that may lead to under-diagnosis of this pathologic process. There is a dearth of randomized controlled trials for the prevention and treatment of AKI associated with cardiac surgery, at least in part due to the paucity of early predictive biomarkers. Novel non-invasive biomarkers have ushered in a new era that allows for earlier detection of AKI. With these new diagnostic tools, a more consistent approach can be employed across centers that may facilitate a more accurate representation of the actual prevalence of AKI and more importantly, clinical investigation that may minimize the occurrence of AKI following pediatric cardiac surgery. A thoughtful management approach is necessary to mitigate the effects of AKI after cardiac surgery, which is best accomplished in close collaboration with pediatric nephrologists. Long-term surveillance for improvement in kidney function and potential development of chronic kidney disease should also be a part of the comprehensive management strategy.

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“…Üriner belirleyicilerden idrar sodyum içe-riği özgün ve duyarlı olmayan bir testtir. Ayrıca filtre edilen yüksek moleküler ağırlıklı proteinler ve tübüler proteinler veya enzimler de idrarda saptanabilen fakat özgün olmayan ayrıca izlem yönü olmayan üriner biyo-belirteçlerdir (31,32).…”

Section: Renal Hasar Biyo-belirteçleriunclassified

Biomarkers in cardiovascular surgery biomarkers as early predictors for organ damage after cardiac surgery

Bozkaya¹

2015

MUSBED

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Cystatin C and neutrophil gelatinase-associated lipocalin: biomarkers for acute kidney injury after congenital heart surgery

Abstract: In patients after congenital heart surgery, urine NGAL indicates the damaging force of cardiopulmonary bypass and serum Cystatin C is a valuable predictive biomarker for resulting acute kidney injury.

Cited by 22 publications

References 22 publications

Serum Cystatin C as an Early Marker of Neutrophil Gelatinase-associated Lipocalin-positive Acute Kidney Injury Resulting from Cardiopulmonary Bypass in Infants with Congenital Heart Disease

Serum Cystatin C as an Early Marker of Neutrophil Gelatinase-associated Lipocalin-positive Acute Kidney Injury Resulting from Cardiopulmonary Bypass in Infants with Congenital Heart Disease

Early detection of acute kidney injury after pediatric cardiac surgery

Biomarkers in cardiovascular surgery biomarkers as early predictors for organ damage after cardiac surgery

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