Cystatin C and parenchymal thickness/kidney length ratio in Wilms tumor survivors

Stefanowicz, Joanna; Kosiak, M; Kosiak, Wojciech; Korbus‐Kosiak, Anna; Sierota, Danuta; Owczuk, Radosław

doi:10.1002/pbc.22249

Cited by 11 publications

(6 citation statements)

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“…Fischbach et al proposed a value of 0.95 mg/dl as a cut-off value and this is the highest value published in the literature [13]. According to Stefanowicz et al, 42% of individuals after treatment of Wilms’ tumour had a serum concentration of cystatin C that was elevated to over 0.95 mg/dl [33]. …”

Section: Discussionmentioning

confidence: 99%

Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors

et al. 2011

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Glomerular filtration rate (GFR) was evaluated in 32 Wilms’ tumour survivors (WTs) in a cross-sectional study using 99 Tc-diethylene triamine pentaacetic acid (99 Tc-DTPA) clearance, the Schwartz formula, the new Schwartz equation for chronic kidney disease (CKD), cystatin C serum concentration and the Filler formula. Kidney damage was established by beta-2-microglobulin (B-2-M) and albumin urine excretion, urine sediment and ultrasound examination. Blood pressure was measured. No differences were found between the mean GFR in 99 Tc-DTPA and the new Schwartz equation for CKD (91.8 ± 11.3 vs. 94.3 ± 10.2 ml/min/1.73 m2 [p = 0.55] respectively). No differences were observed between estimated glomerular filtration rate (eGFR) using the Schwartz formula and the Filler formula either (122.3 ± 19.9 vs. 129.8 ± 23.9 ml/min/1.73 m2 [p = 0.28] respectively). Increased urine albumin and B-2-M excretion, which are signs of kidney damage, were found in 7 (22%) and 3 (9.4%) WTs respectively. Ultrasound signs of kidney damage were found in 14 patients (43%). Five patients (15.6%) had more than one sign of kidney damage. Eighteen individuals (56.25%) had CKD stage I (10 with signs of kidney damage; 8 without). Fourteen individuals (43.75%) had CKD stage II (6 with signs of kidney damage; 8 without). The new Schwartz equation for CKD better estimated GFR in comparison to the Schwartz formula and the Filler formula. Furthermore, the WT survivors had signs of kidney damage despite the fact that GFR was not decreased below 90 ml/min/1.73 m2 with 99 Tc- DTPA.

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Section: Discussionmentioning

confidence: 99%

Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors

et al. 2011

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“…Hypertrophy of a solitary kidney [length or volume of kidney over 2SD (standard deviation of reference value)] in WTS was observed in 50-88% of individuals (9,37,38). Mean value of renal length was 128 ± 14% of the reference value.…”

Section: %mentioning

confidence: 95%

“…In one study, correlation between microalbuminuria and renal volume was observed (40). The parenchymal thickness/kidney length ratio correlated with the deterioration of renal function (cystatin C serum concentration) (38). Currently, in light of the definition of CKD for individuals with the risk of deterioration of kidney function, it is essential not only to assess GFR but also to establish the presence of structural and functional markers of kidney damage.…”

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confidence: 99%

Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today?

Stefanowicz

Kosiak

et al. 2016

Wilms Tumor

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Licence: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. AbstractCurrently, the treatment of Wilms tumour (WT) is successful in approximately 90% of cases, and consists of chemotherapy, nephrectomy, and, in some cases, radiation therapy. All treatments have potential long-term influence on the function of solitary kidneys in WT survivors (WTS). Severe reduction in glomerular filtration rate occurs after nephrectomy. All patients who underwent surgical treatment for WT could be considered to have 132a risk of chronic kidney disease (CKD) because they lack a kidney. End-stage renal disease is rare (1.8% of National Wilms Tumour Study patients). Recent studies have revealed that patients with CKD have a greater risk of cardiovascular events and death. Most of the WTS have lower stages or no CKD. Regular biochemical studies and ultrasound examination at follow-up visits should be considered as indispensible elements of long-term care in uninephrectomized WTS. The evaluation of a single kidney function should be frequent, consisting of the assessment of estimated glomerular filtration rate (eGFR), assessment of albumin urine excretion, urine sediment analysis to detect abnormalities, ultrasound examination and measurements of blood pressure. According to Kidney Disease Improving Global Outcomes (KDIGO) recommendation and suggestions, GFR should be assessed using GFR-estimating equations that include serum creatinine and cystatin C concentrations. Cystatin C can be a more sensitive marker of kidney filtration function than creatinine, especially in diseases characterized by a mild decrease in glomerular filtration. This will facilitate the detection of early kidney impairment and assessment of the progression of CKD in WTS.

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“…Il s'agit d'une mauvaise adaptation, source d'hyperfiltration entraînant à long terme l'apparition d'une microalbuminurie, puis le développement d'une glomérulosclérose, de dommages interstitiels avec fibrose, qui risquent progressivement d'évoluer vers une insuffisance rénale (figure 1) [22,23]. Une étude récente de Stefanowicz et al tend à confirmer que l'hypertrophie, reflet de cette adaptation inadéquate, est corrélée à long terme à une altération de la fonction rénale [24]. La survenue d'une microalbuminurie, reflet de l'hyperfiltration glomérulaire postnéphrectomie, est mal décrite avec des évaluations très hété-rogènes rapportant une incidence de 5 à 84 % de cette complication au-delà de 5 ans post-néphrectomie [20,25] [29].…”

Section: Néphrectomieunclassified

Complications rénales à long terme chez les patients traités pour un cancer dans l’enfance

et al. 2015

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Cystatin C and parenchymal thickness/kidney length ratio in Wilms tumor survivors

Abstract: CysC levels may be elevated in people with normal GFR. Hypertrophy of a single kidney increases with deteriorating kidney function. PT/KL should be verified in future studies as a sonographic marker of kidney impairment.

Cited by 11 publications

References 37 publications

Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors

Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors

Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today?

Complications rénales à long terme chez les patients traités pour un cancer dans l’enfance

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