Cystatin C and Uncontrolled Hypertension

Omaygenç, Mehmet Onur

doi:10.14744/anatoljcardiol.2020.78974

Cited by 3 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, ScysC concentration increases stepwise with the decrease in GFR at late-stage renal failure. Thus, recent research considered ScysC a biomarker of choice to screen for the loss of kidney function in hypertensive patients with urine microalbumin values in the normal range [29].…”

Section: Sensitivity Specificity Positive Predictive Value Negative P...mentioning

confidence: 99%

Sensitivity and specificity of serum cystatin C and creatinine in detecting early stages of chronic kidney disease in Vietnamese patients with hypertension

Nguyen

et al. 2022

Arterial Hypertension

View full text Add to dashboard Cite

Background: Hypertension is one of the most common diseases worldwide, especially in Viet Nam. Screening for early-stage chronic kidney disease (CKD) in patients with hypertension remains controversial. We aimed to analyze the sensitivity and specificity of serum cystatin C and serum creatinine in detecting early-stage kidney function loss as a complication in hypertensive patients. Material and methods: From January 2013 to October 2018, 304 patients first-time diagnosed with primary hypertension at University Medical Center Ho Chi Minh City participated in this cross-sectional study. Collected data includes anthropometric indicators, measured glomerular filtration rate (GFR) by plasma 99mTc-diethylenetriaminepentaacetic clearance, serum cystatin C (ScysC), and serum creatinine (Scr). Results: ScysC level was significantly reciprocal correlation between renal radiography (r = 0.781, p < 0.001). The cutoff value for the identification of GFR < 80 mL/min/1.73 m 2 was ScysC > 1.06 mg/L with a sensitivity of 90.8% and specificity of 90.6%, AUC was 0.90. The sensitivity and specificity of ScysC for the identification of GFR < 70 mL/min/1.73 m 2 and GFR < 60 mL/min/1.73 m 2 was 96.6%, 100% and 98.8%, 99.3%, respectively. Among 14 estimated glomerular filtration formulas used in this study, eGFR-cysC-Filler-Lepage had the highest sensitivity and specificity for identifying GFR < 80 mL/min/1.73 m 2 (79.8% and 100%, respectively). eGFR-cysC-LeBrion had the highest sensitivity and specificity for the identification of GFR < 70 mL/min/1.73 m 2 and GFR < 60 mL/min/1.73 m 2 (97.6%, 96.9% and 100%, 97%; respectively). Conclusion:The sensitivity and specificity of ScysC were significantly higher than Scr. The eGFR-cysC-Filler-Lepage formula had the highest sensitivity and specificity in detecting the early stages of CKD.

show abstract

Section: Sensitivity Specificity Positive Predictive Value Negative P...mentioning

confidence: 99%

Sensitivity and specificity of serum cystatin C and creatinine in detecting early stages of chronic kidney disease in Vietnamese patients with hypertension

Nguyen

et al. 2022

Arterial Hypertension

View full text Add to dashboard Cite

show abstract

Cystatin C as a Marker of Early Kidney Damage Under Arterial Hypertension (Literature Review)

Коval,

Starchenko,

Rieznik

2024

Act. Probl. of the Modern Med.

View full text Add to dashboard Cite

The purpose of this study is to determine kidney functional activity in relation to cystatin C levels, as reported in recent literature. Materials and Methods. A bibliographic-semantic method was employed to assess the current state of research on this topic, analyzing findings from previous scientific studies using both literature sources and electronic resources. Results. Chronic kidney disease (CKD) is as prevalent as hypertension. It is well-known that arterial hypertension exacerbates kidney function, making the assessment of renal functional activity critical. Glomerular filtration rate (GFR) is commonly used to evaluate kidney function, relying on established indicators as well as newer, more objective markers. Among these, cystatin C has emerged as one of the most accurate and sensitive indicators for assessing kidney function. Its concentration in serum negatively correlates with GFR and is particularly valuable for detecting renal pathology even when creatinine levels remain unchanged. This insight has led to the development of an estimated GFR (eGFR) formula that incorporates cystatin C levels. Research suggests that cystatin C levels increase with hypertension, although studies on the specific relationship between cystatin C and hypertension remain limited. Some findings propose that serum cystatin C could serve as a predictor of disease severity, particularly in elderly hypertensive patients with coronary heart disease. The literature supports the utility of cystatin C as a reliable marker for assessing GFR, which facilitates early detection of CKD even when albumin excretion is normal, thus identifying kidney damage at an early stage. Ppotential mechanisms by which elevated cystatin C may contribute to cardiovascular damage are under investigation. As a highly informative endogenous marker of GFR, serum cystatin C not only aids in staging CKD but is especially valuable in identifying early renal dysfunction. Conclusion. The measurement of cystatin C enables a highly accurate assessment of kidney function and aids in evaluating cardiovascular risk, especially when hypertension coexists with chronic kidney disease. Further research is needed to improve predictions of chronic kidney progression at various stages and in the presence of comorbidities. Such insights will support more effective preventive strategies to slow the progression of this pathology.

show abstract

Association of biomarkers of cardiac remodeling, myocardial fibrosis and inflammation with parameters of heart function and structure in patients with arterial hypertension

Andreasova,

Malek,

Zakostelska-Jiraskova

et al. 2024

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

View full text Add to dashboard Cite

Cystatin C and Uncontrolled Hypertension

Cited by 3 publications

References 28 publications

Sensitivity and specificity of serum cystatin C and creatinine in detecting early stages of chronic kidney disease in Vietnamese patients with hypertension

Sensitivity and specificity of serum cystatin C and creatinine in detecting early stages of chronic kidney disease in Vietnamese patients with hypertension

Cystatin C as a Marker of Early Kidney Damage Under Arterial Hypertension (Literature Review)

Association of biomarkers of cardiac remodeling, myocardial fibrosis and inflammation with parameters of heart function and structure in patients with arterial hypertension

Contact Info

Product

Resources

About