Cystatin C assay for the detection of renal dysfunction in Chinese renal transplant recipients

Li, Fu Keung; Ho, Stephen Ka Nung; Yip, Terence; Tse, Kai Chung; Chan, Tak Mao; Lai, Kar Neng

doi:10.1016/s0009-8981(02)00159-6

Cited by 13 publications

(6 citation statements)

References 13 publications

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“…In recent studies, cys-C was shown to be influenced by factors other than renal function [6,7]. Additionally, the results of serum cys-C measurement in kidney transplant patients are still very limited, and mostly belong to the late postoperative period [1,8,9].…”

Section: Introductionmentioning

confidence: 99%

Cystatin-C and creatinine as indices of glomerular filtration rate in the immediate follow-up of renal transplant patients

et al. 2005

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Serum cystatin-C (cys-C), creatinine (Cr), C-reactive protein (CRP) and amyloid A have been shown to provide useful information for renal function following transplantation. In this study, we wanted to evaluate the impact of these parameters as markers of the glomerular filtration rate (GFR) on the third and seventh days of the post-transplantation period. Cys-C was determined by the particle-enhanced immunoturbidimetric assay, and serum amyloid A (SAA) by the sandwich-enzyme immunoassay kit. Cr and CRP concentrations were measured by the Cobas Integra 400 autoanalyser. The patients (n=35) were followed with daily repetitive measurements of serum Cr and urine output per hour, and with Doppler ultrasonography against the risk of rejection. Statistical evaluations were made using the ANOVA and Pearson's test. Serum cys-C and Cr levels on both the 3rd and 7th days after transplantation were lower than those of pretransplantation values (P<0.001). The Cr/cys-C ratio was decreased on the 3rd day of the post-transplantation period, and kept declining on the 7th day. This ratio was high only in the patient with an acute rejection episode. None of the patients with high pretransplant CRP levels had a rejection episode during a six-month follow-up. SAA concentrations were found to be higher than the pretransplant values in the early post-transplant period. Cys-C had good sensitivity to estimate the renal function in the very early period of transplantation, but its value as a marker of GFR was decreased at the end of first week. As none of the 34 patients had a rejection episode, the observed rise in SAA and CRP levels is not specific to rejection.

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Section: Introductionmentioning

confidence: 99%

Cystatin-C and creatinine as indices of glomerular filtration rate in the immediate follow-up of renal transplant patients

et al. 2005

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“…Endogenous markers are of interest due to their speed and simplicity, and they have been anticipated as alternate markers for assessing renal function in renal transplant recipients. [ 9 10 11 12 13 ] At present, serum creatinine, serum cystatin C, and GFR are the parameters being used to diagnose, evaluate prognosis, and monitor the response to treatment. In an agreement with the current study findings, Hermida et al .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Renal Function Using Cystatin C and Creatinine in Saudi Patients after Transplantation

Jeraiby

2021

Annals of African Medicine

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Background: Rapid and accurate assessment of kidney function in patients after transplantation is of utmost importance. The aim of this study was to compare the relationships of serum creatinine and serum cystatin C with an estimated glomerular filtration rate (eGFR) in kidney transplants Saudi patients after a certain period of transplantation. Materials and Methods: In this prospective study, 127 patients were categorized into three groups based on their length of survival after kidney transplantation; <1 year, from 1 to 5 years, and above 5 years after transplantation. Results of cystatin C and creatinine levels were compared by eGFR derived from estimation equation chronic kidney disease epidemiology collaboration. Results: In the three assessed periods, the mean (standard deviation) cystatin C level was 1.72 (0.57), 1.59 (0.64), and 1.82 (0.82), respectively, being highest after 5 years of transplantation, normal in 9.40%, and elevated in 90.60% of the participants, while creatinine level, decreased from 1.57 (0.53) to 1.52 (0.64) in 1–5 years, then it became the highest at 1.75 (0.69) in more than 5 years. The mean was normal in 21.30% and elevated in 78.70% of the patients. Both serum creatinine and cystatin C levels were negatively correlated with posttransplantation time in kidney transplant patients. Conclusion: The cystatin C level was statistically significantly higher after 5 years of transplantation. It is a better parameter to rule out renal dysfunction after transplantation.

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“…Endogenous markers are of interest because of their speed and simplicity, and they have been proposed as alternate marker for assessing renal function in renal transplant recipients. [2][3][4][17][18][19] We established a significant correlation among serum cystatin C with serum creatinine, creatinine clearance rate, Cockroft-Gault formula, and the Modification of Diet in Renal Disease as a marker for GFR. Our results suggest that serum cystatin C correlates well with serum creatinine (r=0.90; P < .001) and creatinine clearance (r=0.77; P < .001), which is similar to the observations made by Pöge and associates 19 and Dharnidharka and associates.…”

Section: Discussionmentioning

confidence: 99%

“…1 Evaluating graft function is crucial for determining long-term graft and patient outcomes. 2 Estimating glomerular filtration rate (GFR) is the best marker for assessing renal function after a kidney transplant. 3 Glomerular filtration rate can be measured by exogenous substances such as inulin and radioisotopes 99m technetium, 51 chromium-EDTA, and I-iothalamate.…”

Section: Introductionmentioning

confidence: 99%

“…3 Clearance assays using creatinine as an endogenous marker currently are used to assess GFR in kidney transplant recipients. [2][3][4] Unfortunately, in these recipients, GFR can be reduced by 50% before creatinine is elevated, and deterioration of graft function may not be shown exactly by slowly rising serum creatinine concentrations. 5,6 Serum creatinine-based GFR is unreliable owing to endogenous influences of sex, age, muscle mass, food ingested, or tubular secretion of creatinine.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Renal Function By Cystatin C in Renal Transplant Recipients

Ayub

Zafar²,

Aziz³

et al. 2014

Exp Clin Transplant

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Cystatin C assay for the detection of renal dysfunction in Chinese renal transplant recipients

Cited by 13 publications

References 13 publications

Cystatin-C and creatinine as indices of glomerular filtration rate in the immediate follow-up of renal transplant patients

Cystatin-C and creatinine as indices of glomerular filtration rate in the immediate follow-up of renal transplant patients

Assessment of Renal Function Using Cystatin C and Creatinine in Saudi Patients after Transplantation

Evaluation of Renal Function By Cystatin C in Renal Transplant Recipients

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