Cystatin C for kidney function assessment in patients with facioscapulohumeral muscular dystrophy

Mondesert, Etienne; Bargnoux, Anne-Sophie; Portet, Florence; Laoudj-Chenivesse, Dalila; Arbogast, Sandrine; Badiou, Stéphanie; Brun, J.‐F.; Kuster, Nils; Mauverger, Éric Raynaud de; Cristol, Jean‐Paul

doi:10.1016/j.cca.2023.117328

Clinica Chimica Acta

2023

DOI: 10.1016/j.cca.2023.117328

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Cystatin C for kidney function assessment in patients with facioscapulohumeral muscular dystrophy

Etienne Mondesert

Anne-Sophie Bargnoux

Florence Portet

et al.

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Diagnostic standard: assessing glomerular filtration rate

Delanaye,

Pottel,

Cavalier

et al. 2023

Nephrology Dialysis Transplantation

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Creatinine-based estimated GFR (eGFR) is imprecise at individual level, due to non-GFR-related serum creatinine determinants, including atypical muscle mass. Cystatin C has the advantage of being independent on muscle mass, a feature that led to the development of race- and sex-free equations. Yet, cystatin C-based equations do not perform better than creatinine-based equations to estimate GFR, unless both variables are included together. The new race-free Chronic Kidney Disease Epidemiology (CKD-EPI) equation, had slight opposite biases between Black and Non-Black subjects in USA, but performs poorer than that the previous version in European populations. The European Kidney Function Consortium (EKFC) equation developed in 2021 can be used both in children and adults, is more accurate in young and old adults, and is applicable to non-white European populations, by rescaling the Q factor, i.e. population median creatinine, in a potentially universal way. A sex- and race-free cystatin C-based EKFC, with the same mathematical design, has also be defined. New developments in the field of GFR estimation would be standardization of cystatin C assays, development of creatinine-based eGFR equations that would incorporate muscle mass data, implementation of new endogenous biomarkers, and the use of artificial intelligence. Standardization of different GFR measurement methods would also be a future challenge, as well as new technologies for measuring GFR. Future research is also needed on discrepancies between cystatin C and creatinine, which is associated with high risk of adverse events: standardize the definition of discrepancy, and understand its determinants.

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Diagnostic standard: assessing glomerular filtration rate

Delanaye,

Pottel,

Cavalier

et al. 2023

Nephrology Dialysis Transplantation

View full text Add to dashboard Cite

show abstract

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Cystatin C for kidney function assessment in patients with facioscapulohumeral muscular dystrophy

Cited by 1 publication

References 35 publications

Diagnostic standard: assessing glomerular filtration rate

Diagnostic standard: assessing glomerular filtration rate

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