Cystatin C in Patients of Metabolic Syndrome and its Correlation with the Individual Components of Metabolic Syndrome

Abstract

Aim:To determine serum cystatin C (CysC) levels in metabolic syndrome (MetS )patients and correlation of cystatin C with individual components of MetS. Materials methods: A cross-sectional study included 100 cases of MetS and 50 controls. One hundred cases were further divided into 3 groups depending upon the number of components of MetS. Anthropometric parameters like height, weight, BMI (body mass index), Waist circumference were measured. Fasting plasma glucose,serum total cholesterol, serum triglycerides, serum HDL (high density lipoprotein), LDL(low density lipoprotein), VLDL (very low density lipoprotein), systolic blood pressure (SBP) and diastolic blood pressure(DBP), creatinine, urea, eGFR (estimated glomerular filtration rate) and CysC were measured in each individual. Correlation of CysC with each component of Mets was studied. Results: CysC was significantly increased in MetS patients than in controls. Level of serum CysC was increased with an increase in components of MetS. CysC was positively correlated with waist circumference, fasting plasma glucose, triglycerides, SBP, and DBP and negatively correlated with HDL. There was no significant difference in urea, creatinine, and eGFR in studied groups. Conclusion: CysC is significantly correlated with individual components of MetS.CysC may be used as an early marker of renal dysfunction in MetS patients.