Cystatin C: influence of perfusion and myocardial injury on early (<24 h) renal function after pediatric cardiac surgery

Abstract

Cystatin C is a sensitive marker of early renal dysfunction following pediatric heart surgery. Variations in bypass parameters, myocardial injury, and ultimately critical oxygen delivery are significantly associated with the degree of renal impairment.

Serum Cystatin C as an Early Marker of Neutrophil Gelatinase-associated Lipocalin-positive Acute Kidney Injury Resulting from Cardiopulmonary Bypass in Infants with Congenital Heart Disease

“…Previous studies in the recent literature have evaluated serum Cys C as an early marker of AKI, as well as its severity, in children sustaining AKI secondary to CPB . They have shown that it is a good marker.…”

“…Previous studies in the recent literature have evaluated serum Cys C as an early marker of AKI, as well as its severity, in children sustaining AKI secondary to CPB. [7][8][9][10][11] They have shown that it is a good marker. But all of these studies are limited by the fact that AKI was defined using either serum Cr or Cr-based estimations of GFR.…”

“…There is increasing evidence that serum Cys C can be used as an early biomarker of AKI resulting from CPB . Multiple studies have evaluated its performance in comparison with serum Cr . A potential limitation of these studies is that they define AKI based on increase in serum Cr or decrease in Cr‐based GFR measurements.…”

“…7,8 Multiple studies have evaluated its performance in comparison with serum Cr. [7][8][9][10][11] A potential limitation of these studies is that they define AKI based on increase in serum Cr or decrease in Cr-based GFR measurements. Recent evidence suggests that urinary neutrophil gelatinase-associated lipocalin (NGAL) is a more specific and sensitive early marker of AKI in this patient population.…”

Urinary kidney biomarkers for early detection of nephrotoxicity in clinical drug development

“…Possible disadvantages of CysC are its dependency on factors other than decline of renal function alone, such as age, gender, weight and height, smoking and high serum C‐reactive protein concentrations . In the clinic, CysC has been shown to be a sensitive marker of early renal dysfunction following ischaemic injury .…”