Cysteine

Cintra, Fátima Dumas; Tufik, Sérgio; D’Almeida, Vânia; Calegare, Bruno Frederico Aguilar; Paola, Angelo de; Oliveira, Wercules; Rizzi, Camila F.; Roizenblatt, Suely; Poyares, Dalva

doi:10.1378/chest.10-0667

Cited by 33 publications

(8 citation statements)

References 35 publications

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“…In addition, the realization that OSA is associated with elevated levels of biochemical or inflammatory markers that may contribute to an increased risk of cardiovascular disease further propelled the field forward in the quest for diagnostic biomarkers. (128)…”

Section: Discussionmentioning

confidence: 99%

Biomarkers associated with obstructive sleep apnea: A scoping review

Canto

Pachêco‐Pereira

Aydınöz

et al. 2015

Sleep Medicine Reviews

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Summary The overall validity of biomarkers in the diagnosis of obstructive sleep apnea (OSA) remains unclear. We conducted a scoping review to provide assessments of biomarkers characteristics in the context of obstructive sleep apnea (OSA) and to identify gaps in the literature. A scoping review of studies in humans without age restriction that evaluated the potential diagnostic value of biological markers (blood, exhaled breath condensate, salivary, and urinary) in the OSA diagnosis was undertaken. Retained articles were those focused on the identification of biomarkers in subjects with OSA, the latter being confirmed with a full overnight or home-based polysomnography (PSG). Search strategies for six different databases were developed. The methodology of selected studies was classified using an adaptation of the evidence quality criteria from the American Academy of Pediatrics. Additionally the biomarkers were classified according to their potential clinical application. We identified 572 relevant studies, of which 117 met the inclusion criteria. Eighty-two studies were conducted in adults, 34 studies involved children, and one study had a sample composed of both adults and children. Most of the studies evaluated blood biomarkers. Potential diagnostic biomarkers were found in 9 pediatric studies and in 58 adults studies. Only 9 studies that reported sensitivity and specificity, which varied substantially from 43% to 100%, and from 45% to 100%, respectively. Thus, studies in adults have focused on the investigation of IL-6, TNF-α and hsCRP. There was not a specific biomarker that was tested by a majority of authors in pediatric studies, and combinatorial urine biomarker approaches have shown preliminary promising results. In adults IL-6 and IL-10 seem to have a favorable potential to become a good biomarker to identify OSA.

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Section: Discussionmentioning

confidence: 99%

Biomarkers associated with obstructive sleep apnea: A scoping review

Canto

Pachêco‐Pereira

Aydınöz

et al. 2015

Sleep Medicine Reviews

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“…Cysteine is derived from homocysteine through a transsulfuration pathway and its increased plasma levels have been associated with cardiovascular risk [ 148 ]. Serum cysteine levels have already been found significantly higher in OSAS patients compared with non-OSAS controls (490.16 ± 67 versus 439.81 ± 76.12 mmol/L, resp., P < 0.01) and this difference was maintained after inclusion of nonobese patients [ 149 ]. Six-month CPAP treatment significantly decreased cysteine levels [ 149 ].…”

Section: New Biomarkersmentioning

confidence: 99%

“…Serum cysteine levels have already been found significantly higher in OSAS patients compared with non-OSAS controls (490.16 ± 67 versus 439.81 ± 76.12 mmol/L, resp., P < 0.01) and this difference was maintained after inclusion of nonobese patients [ 149 ]. Six-month CPAP treatment significantly decreased cysteine levels [ 149 ].…”

Section: New Biomarkersmentioning

confidence: 99%

Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives

et al. 2014

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Obstructive sleep apnea syndrome (OSAS) is characterized by recurrent episodes of upper airway collapse associated with oxygen desaturation and sleep disruption. It is proposed that these periodic changes lead to molecular variations that can be detected by assessing serum biomarkers. Studies have identified inflammatory, oxidative, and metabolic perturbations attributable to sleep-disordered breathing. Given that OSAS is associated with increased cardiovascular and cerebrovascular morbidity, the ideal biomarker should enable timely recognition with the possibility of intervention. There is accumulating data on the utility of serum biomarkers for the evaluation of disease severity, prognosis, and response to treatment. However, current knowledge is limited by data collection techniques, disease complexity, and potential confounding factors. The current paper reviews the literature on the use of serum biomarkers in OSAS. It is concluded that the ideal serum biomarker still needs to be discovered, while caution is needed in the interpretation of hitherto available results.

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“…A number of observational studies have suggested a strong association between obstructive sleep apnea (OSA) and cardiovascular disorders (CVD) [ 1 - 3 ]. Because obesity seems to be the major risk for both conditions, many studies have attempted to separate the effects of OSA on risk factors for CVD from those promoted by obesity [ 4 - 6 ]. Metabolic syndrome (MS) is a set of metabolic abnormalities that appears to stimulate the development of atherosclerotic diseases [ 7 ], and it may be an important confounder for cardiovascular consequences of OSA.…”

Section: Introductionmentioning

confidence: 99%

Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional study

et al. 2015

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BackgroundThe simultaneous occurrence of metabolic syndrome and excessive daytime sleepiness are very common in obstructive sleep apnea (OSA) patients. Both conditions, if present in OSA, have been reported to be associated with inflammation and disruption of oxidative stress balance that impair the cardiovascular system. To verify the impact of daytime sleepiness on inflammatory and oxidative stress markers, we evaluated OSA patients without significant metabolic disturbance.MethodsThirty-five male subjects without diagnostic criteria for metabolic syndrome (Adult Treatment Panel III) were distributed into a control group (n = 10) (43 ± 10.56 years, apnea-hypopnea index - AHI 2.71 ± 1.48/hour), a non-sleepy OSA group (n = 11) (42.36 ± 9.48 years, AHI 29.48 ± 22.83/hour) and a sleepy OSA group (n = 14) (45.43 ± 10.06 years, AHI 38.20 ± 25.54/hour). Excessive daytime sleepiness was considered when Epworth sleepiness scale score was ≥ 10. Levels of high-sensitivity C-reactive protein, homocysteine and cysteine, and paraoxonase-1 activity and arylesterase activity of paraoxonase-1 were evaluated.ResultsPatients with OSA and excessive daytime sleepiness presented increased high-sensitivity C-reactive protein levels even after controlling for confounders. No significant differences were found among the groups in paraoxonase-1 activity nor arylesterase activity of paraoxonase-1. AHI was independently associated and excessive daytime sleepiness tended to have an association with high-sensitivity C-reactive protein.ConclusionsIn the absence of metabolic syndrome, increased inflammatory response was associated with AHI and daytime sleepiness, while OSA was not associated with abnormalities in oxidative stress markers.

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Cysteine

Cited by 33 publications

References 35 publications

Biomarkers associated with obstructive sleep apnea: A scoping review

Biomarkers associated with obstructive sleep apnea: A scoping review

Biomarkers to Improve Diagnosis and Monitoring of Obstructive Sleep Apnea Syndrome: Current Status and Future Perspectives

Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional study

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