Cysteine capped copper/molybdenum bimetallic nanoclusters for fluorometric determination of methotrexate via the inner filter effect

Functional Group-Assisted Fluorescence Sensing Platform for Nanomolar-Level Detection of an Antineoplastic Drug and a Neurotransmitter from Environmental Water and Human Biofluids

“…The overlap between the UV–vis absorbance of methotrexate and the excitation of the probe is the reason behind fluorescence quenching by the inner filter effect . The above-obtained experimental results confirmed that the fluorescence quenching of methotrexate is due to the inner filter effect …”

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

“…With the advent of technologies for NC synthesis and optimization, Cu NCs have been exploited in diagnosis and drug monitoring for different diseases, ranging from cancer to epilepsy ( Table 1 ). Diagnosis using Cu NCs is performed largely based on the detection of abnormal molecular events in the pathological site. In cancer cells, abnormal molecular events are usually manifested in terms of alternations in protein expression, changes in the level of reactive oxygen/nitrogen species, and alternations in intracellular pH .…”

Ligand functionalized copper nanoclusters for versatile applications in catalysis, sensing, bioimaging, and optoelectronics

“…Regarding organic compounds, Cu NC based sensors have been applied for detection of various medications including tramadol, 26 methotrexate, 51 carbamazepine, 52 nitrofurantoin, 42 o-phenylenediamine, 224 doxycycline, 25 and tetracycline; 225 biocidal and herbicidal compounds such as thiram and paraquat; 72 explosive compounds including trinitrotoluene (TNT), 71,226,227 mdinitrobenzene, 55 nitrofurantoin, 34 RDX, 27 and trinitrophenol (TNP); 19,228 food additives such as melamine, 229 folic acid, 56 quinoline yellow, 224 gossypol; 29 humidity and ethanol. 59 Representative examples are presented in Table 1 and are briefly outlined below.…”

“…A fluorescence sensor based on Cu/Mo bimetallic NCs with a PLQY of 26% has been used for detection of methotrexate, an anti-neoplastic drug, within a linear range of 50 nM to 100 mM and LOD of 13.7 nM. 230 CTAB-coated Cu NCs were employed for detecting carbamazepine in exhaled breath condensate within a linear range of 0.2 to 20 mg mL À1 and LOD of 0.08 mg mL À1 . 52 Orange-fluorescent Cu NCs (560 nm) with a PLQY of 5.8% were synthesized using ovalbumin and applied for detecting doxycycline with a linear range from 1 to 1000 mM, and LOD of 270 nM.…”